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US4629449A Expired / Lapsed US ⏱️ 0.0 years remaining

Vaginal dispenser for dispensing beneficial hormone

Assignee: Alza Corp
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Filing: 1985-03-21
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Granted: 1986-12-16
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Expires: 2005-03-21
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Abstract

Abstract The invention is for a method of treating a decrease in estrogen secretion in a woman after the cessation of cyclic ovulation using a vaginal dispenser comprising a wall surrounding an internal lumen and having a pair of ends with one end placed inside the other end to form a closed dispenser. A vaginally administrable beneficial agent is housed in the lumen for release by the dispenser over time.

Inventors

  • 👤 Patrick S. Wong

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-31 09:50
CPC Classifications
A; A61; A61M; A61M31/00; A61M31/002; A61K; A61K9/00; A61K9/0012; A61K9/0034; A61K9/0036

Claims Analysis

Total Claims: 9
Claim 1
Independent Claim 128 words
A method of treating a decrease in estrogen secretion in a woman exhibiting symptoms of a cessation of cyclical ovulation, which method comprises: (a) placing in the vagina of a woman exhibiting symptoms of a cessation of cyclical ovulation a dispenser adapted and shaped for easy placing and comfortable retention in the vagina, the dispenser comprising: (1) body means for housing and estrogen, which body means comprises a vaginally acceptable composition that is essentially-free of deleterious action on the vaginal tissues; and, (2) means in the dispenser for dispensing the estrogen from the dispenser over a prolonged period of time; (b) dispensing the estrogen from the dispenser into the vagina of said woman in a therapeutically effective amount for replacing estrogen and treating the decrease in said woman.
Claim 2
Independent Claim 128 words
A method of treating a decrease in estrogen secretion in a woman exhibiting symptoms of a cessation of cyclical ovulation, which method comprises: (a) placing in the vagina of a woman exhibiting symptoms of a cessation of cyclical ovulation a dispenser adapted and shaped for easy placing and comfortable retention in the vagina, the dispenser comprising: (1) body means for housing and estrogen, which body means comprises a vaginally acceptable composition that is essentially-free of deleterious action on the vaginal tissues; and, (2) means in the dispenser for dispensing the estrogen from the dispenser over a prolonged period of time; (b) dispensing the estrogen from the dispenser into the vagina of said woman in a therapeutically effective amount for replacing estrogen and treating the decrease in said woman.
Claim 3
Dependent Claim 38 words
The method of treating a decrease in estrogen secretion in the woman in need of estrogen replacement according to claim 1, wherein the estrogen is a member selected from the group consisting of naturally occurring and synthetic estrogens.
Claim 4
Dependent Claim 54 words
The method of treating a decrease in estrogen secretion in the woman in need of estrogen replacement according to claim 1, wherein the estrogen is a member selected from the group consisting of estradiol, estradiol benzoate, estradiol cypionate, estradiol dipropionate, estradiol enanthate, conjugated estrogen, estriol, estrone, estrone sulfate, ethinyl estradiol, estrofurate, quinestrol and mestranol.
Claim 5
Dependent Claim 40 words
The method of treating a decrease in estrogen secretion in the woman in need of estrogen replacement according to claim 1, wherein the estrogen in the body means is present as a composition comprising an estrogenic and a progestational steroids.
Claim 6
Independent Claim 131 words
A method for relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman having said periods and in need of estrogen therapy, which method comprises: (a) placing in the vagina of a menopausal, perimenopausal and postmenopausal woman a dispenser adapted and sized for easy placing and comfortable retention in the vagina, the dispenser comprising: (1) body means for housing an estrogen, which body means comprises a vaginally acceptable composition that is essentially-free of deleterious action on the vaginal environment; and, (2) means in the dispenser for dispensing the estrogen from the dispenser over a prolonged period of time; and (b) dispensing into the vagina from the dispenser the estrogen in a therapeutically effective amount for relieving the symptoms associated with menopausal perimenopausal and postmenopausal period in said woman.
Claim 7
Independent Claim 131 words
A method for relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman having said periods and in need of estrogen therapy, which method comprises: (a) placing in the vagina of a menopausal, perimenopausal and postmenopausal woman a dispenser adapted and sized for easy placing and comfortable retention in the vagina, the dispenser comprising: (1) body means for housing an estrogen, which body means comprises a vaginally acceptable composition that is essentially-free of deleterious action on the vaginal environment; and, (2) means in the dispenser for dispensing the estrogen from the dispenser over a prolonged period of time; and (b) dispensing into the vagina from the dispenser the estrogen in a therapeutically effective amount for relieving the symptoms associated with menopausal perimenopausal and postmenopausal period in said woman.
Claim 8
Independent Claim 164 words
A method for relieving the symptoms associated with the menopausal, perimenopausal and postmenopausal periods in a woman having said periods and in need of estrogen therapy, which method comprises: (a) positioning in the vagina of said woman a vaginal dispenser, said vaginal dispenser comprising: (1) body means for housing an estrogenic steroid, said body means comprising a non-toxic, vaginally acceptable, flexible polymeric composition shaped and sized for easy positioning and comfortable retention in the vagina over a prolonged period of time; (2) an estrogenic steroid useful for estrogen therapy in the dispenser present in an amount sufficient for relieving the symptoms; (3) releasing means in the dispenser for dispensing the estrogen from the dispenser over a prolonged period of time; and, (b) relieving the symptoms associated with the menopausal, perimenopausal and postmenopausal periods by delivering the estrogenic steroid in a therapeutically effective amount from the vaginal dispenser to the vagina to produce the intended therapy in said woman over a prolonged period of time.
Claim 9
Independent Claim 164 words
A method for relieving the symptoms associated with the menopausal, perimenopausal and postmenopausal periods in a woman having said periods and in need of estrogen therapy, which method comprises: (a) positioning in the vagina of said woman a vaginal dispenser, said vaginal dispenser comprising: (1) body means for housing an estrogenic steroid, said body means comprising a non-toxic, vaginally acceptable, flexible polymeric composition shaped and sized for easy positioning and comfortable retention in the vagina over a prolonged period of time; (2) an estrogenic steroid useful for estrogen therapy in the dispenser present in an amount sufficient for relieving the symptoms; (3) releasing means in the dispenser for dispensing the estrogen from the dispenser over a prolonged period of time; and, (b) relieving the symptoms associated with the menopausal, perimenopausal and postmenopausal periods by delivering the estrogenic steroid in a therapeutically effective amount from the vaginal dispenser to the vagina to produce the intended therapy in said woman over a prolonged period of time.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1989-12-15 1990-06-16 1990-12-16 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1993-12-15 1994-06-16 1994-12-16 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1997-12-15 1998-06-16 1998-12-16 $7700.00 Window Closed / Lapsed

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