US4626549A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of obesity with aryloxyphenylpropylamines
Assignee: Eli Lilly and Co
•
Filing: 1986-03-31
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Granted: 1986-12-02
•
Expires: 2006-03-31
Abstract
Abstract 3-Aryloxy-3-phenylpropylamines and acid addition salts thereof are useful in blocking uptake of monoamines by brain neurons, and are thus effective in treating disorders of sleep, sexual performance, appetite, muscular function, and pituitary function.
Inventors
- 👤 Bryan B. Molloy
- 👤 Klaus K. Schmiegel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 01:43
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
81 words
A method of treating animals suffering from an appetite disorder comprising administering to said animal an effective amount of a compound of the formula ##STR7## wherein each R' is independently hydrogen or methyl; wherein R is naphthyl or ##STR8## wherein R" and R"' are halo, trifluoromethyl, C 1 -C 4 alkyl, C 1 -C 3 alkyloxy or C 3 -C 4 alkenyl; and wherein n and m are 0, 1 or 2; and acid addition salts thereof formed with pharmaceutically-acceptable acids.
Claim 2
Independent Claim
81 words
A method of treating animals suffering from an appetite disorder comprising administering to said animal an effective amount of a compound of the formula ##STR7## wherein each R' is independently hydrogen or methyl; wherein R is naphthyl or ##STR8## wherein R" and R"' are halo, trifluoromethyl, C 1 -C 4 alkyl, C 1 -C 3 alkyloxy or C 3 -C 4 alkenyl; and wherein n and m are 0, 1 or 2; and acid addition salts thereof formed with pharmaceutically-acceptable acids.
Claim 3
Dependent Claim
15 words
A method according to claim 1 employing N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine or a pharmaceutically-acceptable acid addition salt thereof.
Claim 4
Dependent Claim
8 words
The method of claim 2 employing N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine hydrochloride.
Claim 5
Independent Claim
85 words
A method of blocking the uptake of monoamines by brain neurons in animals comprising administering to said animal a monoamine blocking amount of a compound of the formula ##STR9## wherein each R' is independently hydrogen or methyl; wherein R is naphthyl or ##STR10## wherein R" and R"' are halo, trifluoromethyl, C 1 -C 4 alkyl, C 1 -C 3 alkyloxy or C 3 -C 4 alkenyl; and wherein n and m are 0, 1 or 2; and acid addition salts thereof formed with pharmaceutically-acceptable acids.
Claim 6
Independent Claim
85 words
A method of blocking the uptake of monoamines by brain neurons in animals comprising administering to said animal a monoamine blocking amount of a compound of the formula ##STR9## wherein each R' is independently hydrogen or methyl; wherein R is naphthyl or ##STR10## wherein R" and R"' are halo, trifluoromethyl, C 1 -C 4 alkyl, C 1 -C 3 alkyloxy or C 3 -C 4 alkenyl; and wherein n and m are 0, 1 or 2; and acid addition salts thereof formed with pharmaceutically-acceptable acids.
Claim 7
Dependent Claim
14 words
A method according to claim 4 wherein the monoamine to be blocked is serotonin.
Claim 8
Dependent Claim
15 words
A method according to claim 5 employing N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine or a pharmaceutically-acceptable acid addition salt thereof.
Claim 9
Dependent Claim
8 words
The method of claim 6 employing N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine hydrochloride.
Claim 10
Dependent Claim
14 words
The method of claim 5 employing N-methyl-3-(o-methylphenoxy)-3-phenylpropylamine or a pharmaceutically-acceptable acid addition salt thereof.
Claim 11
Dependent Claim
8 words
The method of claim 5 employing N-methyl-3-(o-methylphenoxy)-3-phenylpropylamine hydrochloride.
References Cited (Backward Citations)
US2683742A
Cited
US3106564A
Cited
US3132179A
Cited
US3253040A
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US3562330A
Cited
US4018895A
Cited
US4194009A
Cited
US4313896A
Cited
US4314081A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-12-01 | 1990-06-02 | 1990-12-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-12-01 | 1994-06-02 | 1994-12-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-12-01 | 1998-06-02 | 1998-12-02 | $7700.00 | Window Closed / Lapsed |