US4623660A
Expired / Lapsed
US
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Triphenylalkene derivatives
Assignee: Imperial Chemical Industries Ltd
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Filing: 1979-12-03
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Granted: 1986-11-18
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Expires: 1999-12-03
Abstract
Abstract The disclosure relates to 1-p-aminoalkoxy phenyl-1-p-hydroxyphenyl-2-phenylalk-1-ene derivatives, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess anti-oestrogenic activity and are useful in the treatment of anovulatory infertility and the breast tumors. Representative of the compounds disclosed is 1-(p- beta -dimethylaminoethoxyphenyl)-trans-1-p-hydroxyphenyl-2-p-tolylbut-1-ene .
Inventors
- 👤 Dora N. Richardson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 05:11
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; A; A61; A61P; A61P15/00; C07C; C07C45/00; C07C45/45; C07C45/46; C07C45/61; C07C45/67; C07C45/673; C07C45/68; C07C45/70; C07C45/71; C07C49/00; C07C49/76; C07C49/82; C07C49/83; C07C49/84; C07C51/00; C07C51/58; C07C51/60; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12; C07D339/00; C07D339/08
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
98 words
An alkene derivative of the formula: ##STR17## wherein either R 1 is a hydrogen atom or a lower alkyl radical and R 2 is a lower alkyl radical, or R 1 and R 2 are joined together with the adjacent nitrogen atom to form a heterocyclic radical; R 3 is a halogen atom or a lower alkyl radical; R 4 is a halogen atom, or a hydroxy or lower alkyl radical, or is the buta-1,3-dienyl radical such that together with the benzene ring it forms a naphthyl radical; and n is 2 or a pharmaceutically-acceptable acid-addition salt thereof.
Claim 2
Dependent Claim
98 words
An alkene derivative of the formula: ##STR17## wherein either R 1 is a hydrogen atom or a lower alkyl radical and R 2 is a lower alkyl radical, or R 1 and R 2 are joined together with the adjacent nitrogen atom to form a heterocyclic radical; R 3 is a halogen atom or a lower alkyl radical; R 4 is a halogen atom, or a hydroxy or lower alkyl radical, or is the buta-1,3-dienyl radical such that together with the benzene ring it forms a naphthyl radical; and n is 2 or a pharmaceutically-acceptable acid-addition salt thereof.
Claim 3
Dependent Claim
52 words
An alkene derivative as claimed in claim 1 wherein R 1 and R 2 are both the same lower alkyl radical, wherein R 3 is a lower alkyl radical, wherein R 4 is a halogen atom or a lower alkyl radical, and wherein n is 2, or a pharmaceutically-acceptable acid-addition salt thereof.
Claim 4
Dependent Claim
49 words
An alkene derivative as claimed in claim 2 wherein R 1 and R 2 are both methyl radicals, R 3 is an ethyl radical, R 4 is a fluorine, chlorine or bromine atom or a methyl or ethyl radical, and n is 2, or a pharmaceutically-acceptable acid-addition salt thereof.
Claim 5
Dependent Claim
27 words
An alkene derivative as claimed in claim 3 wherein the substituent R 4 is in the 4-position of the benzene ring, or a pharmaceutically-acceptable acid-addition salt thereof.
Claim 6
Dependent Claim
14 words
A compound claimed in claim 1 selected from 1-p-β-dimethylaminoethoxyphenyl)-cis-p-hydroxyphenyl-2-p-tolylbut-1-ene, 1-(p-dimethylaminoethoxyphenyl)-trans-1-p-hydroxyphenyl-2-p-chlorophenylbut-1-ene, 1-p-β-dimethylaminoethoxyphenyl)-cis-1-p-hydroxyphenyl-2-p-chlorophenylbut-1-ene, 1-(p-β-dimethylaminoethoxyphenyl)-trans-1-p-hydroxyphenyl-2-p-fluorophenylbut-1-ene and 1-(p-β-dimethylaminoethoxyphenyl)cis-1-p-hydroxyphenyl-2-p-fluorophenyl-but-1-ene.
Claim 7
Dependent Claim
25 words
A pharmaceutical composition which comprises an alkene derivative or a pharmaceutically-acceptable acid-addition salt thereof, claimed in claim 1, together with a pharmaceutically-acceptable diluent or carrier.
Claim 8
Dependent Claim
40 words
A method for producing an antioestrogenic effect in a warm-blooded animal in need of such an effect which comprises administering to said animal an effective amount of an alkene derivative or a pharmaceutically-acceptable acid-addition salt thereof claimed in claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-11-17 | 1990-05-19 | 1990-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-11-17 | 1994-05-19 | 1994-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-11-17 | 1998-05-19 | 1998-11-18 | $7700.00 | Window Closed / Lapsed |