US4623539A
Expired / Lapsed
US
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Nutrient barrier polysaccharide compositions and method of use
Assignee: Individual
•
Filing: 1985-03-25
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Granted: 1986-11-18
•
Expires: 2005-03-25
Abstract
Abstract Disclosed are method and composition for periodically coating the internal, food absorbing surface of the small intestine of a mammal by ingesting said composition which is capable of forming at least a partial nutrient barrier on said intestine.
Inventors
- 👤 Deger C. Tunc
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 00:31
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A23; A23L; A23L33/00; A23L33/20; A23L33/21
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
114 words
An oral composition of matter for coating the small intestine of a mammal comprising: a polymeric material that is capable of forming a nutrient barrier in the pH environment of 5.5 to 8.5 of the small intestine, said polymeric material having atoms containing polarizable electrons thereon, said atoms being selected from the group consisting of oxygen, nitrogen, sulfur in combination with a divalent cation said divalent cation is selected from the group consisting of Ca ++ , Mg ++ , Zn ++ and Ba ++ wherein the ratio of said atom containing polarizable electrons thereon to said divalent cation is in the range of 7.7 to 1 or <1 in a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
114 words
An oral composition of matter for coating the small intestine of a mammal comprising: a polymeric material that is capable of forming a nutrient barrier in the pH environment of 5.5 to 8.5 of the small intestine, said polymeric material having atoms containing polarizable electrons thereon, said atoms being selected from the group consisting of oxygen, nitrogen, sulfur in combination with a divalent cation said divalent cation is selected from the group consisting of Ca ++ , Mg ++ , Zn ++ and Ba ++ wherein the ratio of said atom containing polarizable electrons thereon to said divalent cation is in the range of 7.7 to 1 or <1 in a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
13 words
The composition of claim 1 wherein said pharmaceutically acceptable carrier is a liquid.
Claim 4
Dependent Claim
13 words
The composition of claim 1 wherein said pharmaceutically acceptable carrier is a solid.
Claim 5
Dependent Claim
48 words
The composition of claim 1 wherein the polymeric material is an anionic carboxylated polysaccharide having the formula ##STR12## wherein R=pectin: D-galacturonoglycan in which the D-galactopyranosyluronic acid units are connected by (1→4) glycosidic linkages; algin: anhydro-D-mannuronic acid and anhydro-L-guluronic acid residues; or gum karaya: D-galacturonic acid, D-galactose and L-rhamnose.
Claim 6
Dependent Claim
44 words
The composition of claim 1 wherein the polymeric material is an anionic cellulose derivative having the formulae ##STR13## where R=anhydroglucose residue; R'=CH 3 , C 2 H 5 , or C 3 H 7 ; R"=CH 3 , or C 2 H 5 .
Claim 7
Dependent Claim
14 words
The composition of claim 5 wherein said anionic cellulose derivative is sodium ethylcellulose sulfate.
Claim 8
Dependent Claim
15 words
The composition of claim 5 wherein said anionic cellulose derivative is sodium cellulose acetate sulfate.
Claim 9
Dependent Claim
13 words
The composition of claim 5 wherein said anionic cellulose derivative is carboxymethyl cellulose.
Claim 10
Dependent Claim
24 words
The composition of claim 1 wherein the polymeric material is an anionic sulfated synthetic polymer having the formula ##STR14## wherein R=(poly)alkyl or (poly)aryl sulfone.
Claim 11
Dependent Claim
26 words
The composition of claim 1 wherein the polymeric material is an anionic sulfonated synthetic polymer having the formula ##STR15## wherein R=(poly)styrene; (poly)alkyl or (poly)aryl sulfone resin.
Claim 12
Dependent Claim
22 words
The composition of claim 1 wherein the polymeric material is an anionic carboxylated synthetic polymer having the formula ##STR16## wherein R-poly(vinyl carboxylate).
Claim 13
Dependent Claim
31 words
The composition of claim 1 wherein the polymeric material is a cationic aminopolysaccharide having the formula ##STR17## wherein R=an anhydroglucose unit and R'=CH 3 , or C 2 H 5 .
Claim 14
Dependent Claim
11 words
The composition of claim 12 wherein the aminopolysaccharide is chondroitin sulfate.
Claim 15
Dependent Claim
11 words
The composition of claim 12 wherein the aminopolysaccharide is dermatan sulfate.
Claim 16
Dependent Claim
10 words
The composition of claim 12 wherein the aminopolysaccharide is keratosulfate.
Claim 17
Dependent Claim
11 words
The composition of claim 12 wherein the aminopolysaccharide is hyaluronic acid.
Claim 18
Dependent Claim
10 words
The composition of claim 12 wherein the aminopolysaccharide is heparin.
Claim 19
Dependent Claim
10 words
The composition of claim 12 wherein the aminopolysaccharide is chitin.
Claim 20
Dependent Claim
25 words
The composition of claim 1 wherein the polymeric material is neutral synthetic polymer selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol or polyethylene oxide.
Claim 21
Dependent Claim
30 words
A method of reducing the amount of nutrient absorption in the small intestine of a mammal by administering to said mammal an effective amount of the composition of claim 1.
Claim 22
Dependent Claim
16 words
The method of claim 20 wherein said composition is administered to said mammal prior to feeding.
Claim 23
Dependent Claim
16 words
The method of claim 20 wherein said composition is administered to said mammal along with feeding.
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