6-aryl pyrimidines for treating aplastic anemia

Claim 1

A process for treating aplastic anemia comprising the systemic administration of an effective amount for treating aplastic anemia of a compound of the formula: ##STR26## wherein X 3 is equal to X, X 4 , or X 5 wherein X 4 is fluoro, chloro, bromo or iodo, and X 5 is mono-, di- or trihalo methyl, mono-, di- or trifluoroethyl, perfluoropropyl and X is alkyl of from 1 to 3 carbon atoms, inclusive, 2-propynyl, 2-propenyl, and alkyloxyacyl where alkyl is as defined above, and X 1 is a member selected from the group consisting of: (a) phenyl, (b) a monosubstituted phenyl of the formula: ##STR27## wherein provided that only one of groups R, R 1 , R 2 , R 3 , R 4 is other than hydrogen and R or R 4 is alkyl of from 1 to 8 carbon atoms, inclusive, including isomeric forms, alkoxy of from 1 to 8 carbon atoms, inclusive, including isomeric forms, fluoro, chloro, bromo, iodo, or nitro; R 1 or R 3 is fluoro, chloro, bromo, iodo, nitro, trifluoromethyl or alkoxy of from one to eight carbon atoms, alkoxyethyloxy wherein alkoxy is from 1 to 5 carbon atoms, inclusive, or ##STR28## wherein R 5 and R 6 are the same or different and are alkyl of from 1 to 8 carbon atoms, inclusive, benzyl or taken together with --N< are a saturated cycloalkylamino group ##STR29## wherein n' is 3, 4, 5 or 6 or dialkyl substituted cycloalkylamino wherein each alkyl is from 1 to 3 carbon atoms, inclusive; and R 2 is chloro, fluoro, bromo, iodo, or alkyl of from 1 to 3 carbon atoms, inclusive, (c) a disubstituted phenyl of the formula: ##STR30## wherein any two of R, R 1 , R 2 , R 3 and R 4 are not hydrogen and are the same or different and are fluoro, chloro, bromo, iodo, alkyl of from 1 to 8 carbon atoms, including isomeric forms, alkoxy of from 1 to 8 carbon atoms, inclusive isomeric forms, nitro and trifluoromethyl; (d) a trihalo substituted phenyl wherein halo is chloro, bromo, iodo or fluoro, (e) α-naphthyl of the formula: ##STR31## wherein R is substituted in either ring and is hydrogen, alkyl of from 1 to 8 carbon atoms, inclusive, including isomeric forms, alkoxy of from 1 to 8 carbon atoms, inclusive, including isomeric forms, fluoro, chloro, iodo, bromo or nitro, (f) 2-furyl, (g) 3-pyridyl, (h) 2-pyridyl and (i) 2-pyrazyl, or a salt thereof in association with a pharmaceutical carrier to a human or animal having aplastic anemia.