US4619827A
Expired / Lapsed
US
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Method for administering equine vaccines and compositions therefor
Assignee: Neogen Corp
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Filing: 1985-10-07
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Granted: 1986-10-28
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Expires: 2005-10-07
Abstract
Abstract A method for enhancing a vaccine immune response in equines using leukokines, particularly mixed leucokines, is described. The leukokines can be administered separately or admixed with the vaccine. The method and vaccine compositions are particularly effective where equine influenza vaccine and mixed leukokines are administered together to the equine.
Inventors
- 👤 Robert W. Bull
- 👤 Robert M. Soltysiak
- 👤 Paul D. Minnick
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 23:46
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/39; A61K45/00; A61K45/05; A61K2039/555; A61K2039/55511; A61K2039/55522
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
48 words
In a method for providing an immune response to an equine disease with a viral or viral subunit or other viral-derived antigen vaccine which produces a blood serum improvement which comprises: administering an equine leukokine with the vaccine to thereby provide an enhanced immune response in the equine.
Claim 2
Dependent Claim
48 words
In a method for providing an immune response to an equine disease with a viral or viral subunit or other viral-derived antigen vaccine which produces a blood serum improvement which comprises: administering an equine leukokine with the vaccine to thereby provide an enhanced immune response in the equine.
Claim 3
Dependent Claim
17 words
The method of claim 1 wherein the vaccine and leukokine are administered in admixture to the equine.
Claim 4
Dependent Claim
30 words
The method of claim 1 wherein prior to administration the leukokine has been induced by a virus in a medium containing leucocytes and then separated from the medium and leucocytes.
Claim 5
Dependent Claim
17 words
The method of claim 3 wherein the virus which induced the leukokine produces Newcastles disease in chickens.
Claim 6
Dependent Claim
12 words
The method of claim 1 wherein the vaccine is for equine influenza.
Claim 7
Dependent Claim
25 words
The method of claim 5 wherein between about 20,000 and 1,000,000 International Antiviral Units of the leukokine are administered to the equine with the vaccine.
Claim 8
Dependent Claim
15 words
The method of claim 1 wherein the leukokine and vaccine are administered separately and concurrently.
Claim 9
Dependent Claim
14 words
The method of claim 1 wherein the vaccine and leukokines are administered by injection.
Claim 10
Dependent Claim
39 words
The method of claim 1 wherein the administration is by injection, wherein the vaccine and leukokine are administered separately and concurrently and wherein the leukokine is induced in the leucocytes by a virus which produces Newcastles disease in chickens.
Claim 11
Dependent Claim
17 words
The method of claim 1 wherein the leukokine is an admixture of leukokines of different molecular size.
Claim 12
Dependent Claim
92 words
A vaccine composition for an equine which comprises in admixture: (a) a viral or viral subunit or other viral-derived antigen vaccine which produces a blood serum antibody response to the vaccine in the equine to provide an immune response to a viral disease; and (b) an equine leukokine as an adjuvant to the vaccine, wherein the leukokine is present with the vaccine in a dosage of 0.1 to 5 ml of the composition in an amount which increases the blood serum antibody response to the vaccine in the equine when administered intramuscularly.
Claim 13
Dependent Claim
92 words
A vaccine composition for an equine which comprises in admixture: (a) a viral or viral subunit or other viral-derived antigen vaccine which produces a blood serum antibody response to the vaccine in the equine to provide an immune response to a viral disease; and (b) an equine leukokine as an adjuvant to the vaccine, wherein the leukokine is present with the vaccine in a dosage of 0.1 to 5 ml of the composition in an amount which increases the blood serum antibody response to the vaccine in the equine when administered intramuscularly.
Claim 14
Dependent Claim
29 words
The vaccine composition of claim 11 wherein the leukokine prior to admixture has been induced by a virus in a medium containing leucocytes and then separated from the medium.
Claim 15
Dependent Claim
18 words
The vaccine composition of claim 12 wherein the virus which induced the leukokine produces Newcastles disease in chickens.
Claim 16
Dependent Claim
18 words
The vaccine composition of claim 11 wherein the leukokines are a mixture of leukokines of different molecular size.
Claim 17
Dependent Claim
83 words
An influenza vaccine composition for an equine which comprises in admixture: (a) a viral influenza vaccine which produces a blood serum antibody response to the vaccine in the equine to provide equine influenza immunity; and (b) an equine leukokine as an adjuvant to the vaccine, wherein the leukokine is present with the vaccine in a dosage of 0.1 to 5 ml of the composition in an amount which increases the blood serum antibody response to the vaccine in the equine when administrated intramuscularly.
Claim 18
Dependent Claim
83 words
An influenza vaccine composition for an equine which comprises in admixture: (a) a viral influenza vaccine which produces a blood serum antibody response to the vaccine in the equine to provide equine influenza immunity; and (b) an equine leukokine as an adjuvant to the vaccine, wherein the leukokine is present with the vaccine in a dosage of 0.1 to 5 ml of the composition in an amount which increases the blood serum antibody response to the vaccine in the equine when administrated intramuscularly.
Claim 19
Dependent Claim
23 words
The vaccine composition of claim 15 wherein between about 20,000 and 100,000 Internation Antiviral Units of the leukokines in the vaccine are administered.
Claim 20
Dependent Claim
20 words
The vaccine composition of claim 16 wherein the vaccine is administered in a dosage between about 0.1 to 5 ml.
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