US4617304A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Purine derivatives
Assignee: Merck and Co Inc
•
Filing: 1984-04-10
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Granted: 1986-10-14
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Expires: 2004-04-10
Abstract
Abstract Purines and pyrimidines having a fused cyclopropane ring in the side chain and the heterocyclic isosteres of said purines and pyrimidines have antiviral activity, especially against viruses of the herpes class.
Inventors
- 👤 Wallace Ashton
- 👤 Edward Walton
- 👤 Richard L. Tolman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 19:33
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/46; C07D239/47; A; A61; A61P; A61P31/00; A61P31/12; C07C; C07C255/00; C07D233/00; C07D233/54; C07D233/66; C07D233/90; C07D239/48; C07D239/50; C07D239/52; C07D239/54; C07D303/00; C07D303/02; C07D303/12; C07D303/16; C07D471/00; C07D471/02; C07D471/04; C07D473/00; C07D487/00; C07D487/02; C07D487/04
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
63 words
A compound of the formula ##STR5## and the pharmaceutically acceptable salts thereof wherein Y is a purin-9-yl or a heterocyclic isostere of a purin-9-yl group; R 1 is selected from hydrogen and alkyl of 1 to 4 carbon atoms; R 2 is selected from hydrogen, alkyl of 1 to 4 carbon atoms, and --CH 2 OH; and Z is >CH 2 or >O.
Claim 2
Dependent Claim
63 words
A compound of the formula ##STR5## and the pharmaceutically acceptable salts thereof wherein Y is a purin-9-yl or a heterocyclic isostere of a purin-9-yl group; R 1 is selected from hydrogen and alkyl of 1 to 4 carbon atoms; R 2 is selected from hydrogen, alkyl of 1 to 4 carbon atoms, and --CH 2 OH; and Z is >CH 2 or >O.
Claim 3
Dependent Claim
12 words
A compound according to claim 1 wherein Y is a purin-9-yl group.
Claim 4
Dependent Claim
10 words
A compound according to claim 1 wherein Y is ##STR6##
Claim 5
Dependent Claim
10 words
A compound according to claim 1 wherein Y is ##STR7##
Claim 6
Dependent Claim
10 words
A compound according to claim 1 wherein Y is ##STR8##
Claim 7
Dependent Claim
5 words
9-[(Z)-2-(Hydroxymethyl)cyclopropylmethyl]guanine, according to claim 1.
Claim 8
Dependent Claim
19 words
An antiviral pharmaceutical composition comprising an effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
27 words
A method of treating virus infections in mammals comprising administering to a mammal in need of such treatment an effective amount of a compound of claim 1.
References Cited (Backward Citations)
US4294831A
Cited
US4230708A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-10-13 | 1990-04-14 | 1990-10-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-10-13 | 1994-04-14 | 1994-10-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-10-13 | 1998-04-14 | 1998-10-14 | $7700.00 | Window Closed / Lapsed |