US4617149A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Growth hormone release factor analogs
Assignee: Eli Lilly and Co
•
Filing: 1983-09-21
•
Granted: 1986-10-14
•
Expires: 2003-09-21
Abstract
Abstract A class of compounds having growth hormone releasing activity is described. These compounds have the formula H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-X-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-Y in which Y is OH or NH 2 and X is selected from the group consisting of Met(O), Met(S-Me), Hse, Gln, Asn, Ser, Thr, Leu, Ile, Ala, Gly, Pro, Val, Phe, Trp, Tyr, Cys, Lys, Arg, His, Glu, and Asp.
Inventors
- 👤 Richard D. DiMarchi
- 👤 Carl J. Shaar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 02:19
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/60; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/12
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
32 words
A compound having the formula H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-X-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-Y in which Y is OH or NH 2 and X is selected from the group consisting of Met(O), Met(S-Me), and Hse and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
32 words
A compound having the formula H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-X-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-Y in which Y is OH or NH 2 and X is selected from the group consisting of Met(O), Met(S-Me), and Hse and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
9 words
Compound of claim 1, in which Y is OH.
Claim 4
Dependent Claim
11 words
Compound of claim 1, in which Y is NH 2 .
Claim 5
Dependent Claim
15 words
Compound of claim 1, in which X is Met(O) and Y is NH 2 .
Claim 6
Dependent Claim
15 words
Compound of claim 1, in which X is Met(S-Me) and Y is NH 2 .
Claim 7
Dependent Claim
15 words
Compound of claim 1, in which X is Hse, and Y is NH 2 .
References Cited (Backward Citations)
EP0117034A2
Cited
US4529595A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-10-13 | 1990-04-14 | 1990-10-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-10-13 | 1994-04-14 | 1994-10-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-10-13 | 1998-04-14 | 1998-10-14 | $7700.00 | Window Closed / Lapsed |