US4615876A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides
Assignee: University of Missouri System
•
Filing: 1983-04-25
•
Granted: 1986-10-07
•
Expires: 2003-04-25
Abstract
Abstract Stable neutral-lipophilic complexes of technetium-99m (Tc-99m) useful as diagnostic radionuclidic imaging agents are formed by complexing technetium-99m pertechnetate with alkylene amine oximes (viz. propylene amine oxime) in aqueous solutions under reducing conditions. The complexes have a zero charge, contain an O-H-O ring closure bond, and are sufficiently stable for parental administration in imaging by scintillation scanning. Substituents can be attached to the C2 to C4 alkylene carbon backbone of the tetradentate amine oxime ligands to structurally modify them and produce a variety of Tc-99m-radiopharmaceuticals with specific body imaging applications.
Inventors
- 👤 David E. Troutner
- 👤 Wynn A. Volkert
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 05:18
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/12; C07D295/125; C07D295/13; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; C07C; C07C51/00; C07C51/347; C07C51/363; C07C53/00; C07C53/15; C07C53/19; C07D295/14; C07D295/145; C07D295/15; C07F; C07F13/00; C07F13/005; A61K2123/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
65 words
The class of lipophilic macrocyclic complexes of technetium-99m (Tc-99m) useful as diagnostic radionuclides, said complexes being formed by complexing in aqueous solution technetium-99m pertechnetate (TcO 4 - -99m) under reducing conditions with an alkylene amine oxime containing from 2 to 4 carbons in the alkylene group, said complexes having a zero charge, containing an O--H--O ring closure bond, and being sufficiently stable for parenteral administration.
Claim 2
Dependent Claim
65 words
The class of lipophilic macrocyclic complexes of technetium-99m (Tc-99m) useful as diagnostic radionuclides, said complexes being formed by complexing in aqueous solution technetium-99m pertechnetate (TcO 4 - -99m) under reducing conditions with an alkylene amine oxime containing from 2 to 4 carbons in the alkylene group, said complexes having a zero charge, containing an O--H--O ring closure bond, and being sufficiently stable for parenteral administration.
Claim 3
Dependent Claim
14 words
The macrocyclic complexes of claim 1 in which said oxime is propylene amine oxime.
Claim 4
Dependent Claim
18 words
The macrocyclic complexes of claim 1 in which said alkylene group is substituted with a lipophilic hydrocarbon group.
Claim 5
Dependent Claim
26 words
The macrocyclic complexes of claim 1 in which said alkylene group is substituted with a long chain fatty acid group containing from 6 to 22 carbons.
Claim 6
Dependent Claim
14 words
The complexes of claim 1 having a single oxygen bonded to the reduced Tc-99m.
Claim 7
Dependent Claim
19 words
The complexes of claim 1 in which said alkylene group is substituted by an alkyl amine or polyalkylamine group.
Claim 8
Dependent Claim
14 words
The macrocyclic complexes of claim 1 in which said oxime is ethylene amine oxime.
Claim 9
Dependent Claim
64 words
The macrocyclic complex of technetium-99m (Tc-99m) useful as a diagnostic radionuclide which is formed by complexing in aqueous solution technetium-99m pertechnetate (TcO 4 - -99m) under reducing conditions with 2,2'-(1,3-diaminopropane) bis(2-methyl-3-butanone) dioxime (PnAO), said complex having a zero charge, containing an O--H--O ring closure bond, having a single oxygen bonded to the reduced Tc-99m, and being stable in aqueous solution when exposed to oxygen.
Claim 10
Dependent Claim
64 words
The macrocyclic complex of technetium-99m (Tc-99m) useful as a diagnostic radionuclide which is formed by complexing in aqueous solution technetium-99m pertechnetate (TcO 4 - -99m) under reducing conditions with 2,2'-(1,3-diaminopropane) bis(2-methyl-3-butanone) dioxime (PnAO), said complex having a zero charge, containing an O--H--O ring closure bond, having a single oxygen bonded to the reduced Tc-99m, and being stable in aqueous solution when exposed to oxygen.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-10-06 | 1990-04-07 | 1990-10-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-10-06 | 1994-04-07 | 1994-10-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-10-06 | 1998-04-07 | 1998-10-07 | $7700.00 | Window Closed / Lapsed |