US4614796A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Liposome and method of manufacture therefor
Assignee: Nippon Shinyaku Co Ltd
•
Filing: 1983-03-25
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Granted: 1986-09-30
•
Expires: 2003-03-25
Abstract
Abstract Liposomes of steryl glucosides and/or steryl glucoside monopalmitates are useful for hemostatic, vascular stabilization and anti-shock effects, particularly in the form of injectable solutions.
Inventors
- 👤 Masanobu Kawamata
- 👤 Koichi Ushimaru
- 👤 Shuji Yamane
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 17:24
CPC Classifications
C; C07; C07J; C07J17/00; C07J17/005; A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; A61K9/1272
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
26 words
A liposome comprising a steryl glucoside and/or a steryl glucoside monopalmitate, water and a lipid selected from the group consisting of natural and synthetic phosphatidyl cholines.
Claim 2
Dependent Claim
26 words
A liposome comprising a steryl glucoside and/or a steryl glucoside monopalmitate, water and a lipid selected from the group consisting of natural and synthetic phosphatidyl cholines.
Claim 3
Dependent Claim
12 words
The liposome according to claim 1, in the form of simple lamella.
Claim 4
Dependent Claim
12 words
The liposome according to claim 1, in the form of multi-layered lamella.
Claim 5
Dependent Claim
15 words
The liposome according to claim 1, in which said natural phosphatidyl choline is yolk lecithin.
Claim 6
Dependent Claim
35 words
The liposome according to claim 1, in which said synthetic phosphatidyl choline is selected from the group consisting of dimyristoil phosphatidyl choline, dipalmitoyl phosphatidyl choline, distearyl phosphatidyl choline and dioleyl phosphatidyl choline and mixtures thereof.
Claim 7
Dependent Claim
18 words
The liposome according to claim 1, in which a sterol is included as a stabilizer for the liposome.
Claim 8
Dependent Claim
25 words
The liposome according to claim 6, in which said sterol is selected from the group consisting of cholesterol, β-sitosterol, stigmasterol and campesterol and mixtures thereof.
Claim 9
Dependent Claim
15 words
The liposome according to claim 1, including a charging agent that donates a positive charge.
Claim 10
Dependent Claim
17 words
The liposome according to claim 8, in which said charging agent donating a positive charge is stearylamine.
Claim 11
Dependent Claim
19 words
The liposome according to claim 1, in which the liposome contains a charging agent that donates a negative charge.
Claim 12
Dependent Claim
17 words
The liposome according to claim 10, in which the charging agent is phosphatidic acid or dicetylphosphoric acid.
Claim 13
Dependent Claim
38 words
The liposome according to claim 1, in which said steryl glucoside is selected from the group consisting of -β-sitosteryl-β-D-glucoside, stigmasteryl-β-D-glucoside, campesteryl-β-D-glucoside and cholesteryl-β-D-glucoside and a mixture thereof and said sterylglucoside monopalmitate is a monopalmitate of said steryl glucoside.
Claim 14
Dependent Claim
38 words
The liposome according to claim 1, in which said steryl glucoside is selected from the group consisting of -β-sitosteryl-β-D-glucoside, stigmasteryl-β-D-glucoside, campesteryl-β-D-glucoside and cholesteryl-β-D-glucoside and a mixture thereof and said sterylglucoside monopalmitate is a monopalmitate of said steryl glucoside.
Claim 15
Dependent Claim
38 words
The liposome according to claim 6, in which said steryl glucoside is selected from the group consisting of -β-sitosteryl-β-D-glucoside, stigmasteryl-β-D-glucoside, campesteryl-β-D-glucoside and cholesteryl-β-D-glucoside and a mixture thereof and said sterylglucoside monopalmitate is a monopalmitate of said steryl glucoside.
Claim 16
Dependent Claim
38 words
The liposome according to claim 8, in which said steryl glucoside is selected from the group consisting of -β-sitosteryl-β-D-glucoside, stigmasteryl-β-D-glucoside, campesteryl-β-D-glucoside and cholesteryl-β-D-glucoside and a mixture thereof and said sterylglucoside monopalmitate is a monopalmitate of said steryl glucoside.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-29 | 1990-03-31 | 1990-09-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-29 | 1994-03-31 | 1994-09-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-29 | 1998-03-31 | 1998-09-30 | $7700.00 | Window Closed / Lapsed |