US4613666A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Neplanocin A derivatives
Assignee: Asahi Kasei Corp
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Filing: 1985-09-16
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Granted: 1986-09-23
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Expires: 2005-09-16
Abstract
Abstract Neplanocin A derivatives of the formula <IMAGE> wherein R1 and R2 are hydrogen or benzoyl, R3 is hydrogen or OR8, R5 is hydrogen or acetyl, R6 is hydrogen, acetyl or benzoyl, when R3 is hydrogen, R4 is hydrogen or halogen, hydroxy, acetoxy, acetylthio, amino or azide, and when R3 is OR8, R4 is hydrogen, R8 is hydrogen or acetyl, or R8 and R5 together form benzylidene, and at least one of R8, R5 and R6 is other than hydrogen. The compounds of the present invention have inhibitory action for the growth of L 5178 Y cells and have the same or superior activity as neplanocin A, and hence are useful as antitumor agents.
Inventors
- 👤 Kiyofumi Fukukawa
- 👤 Takao Hirano
- 👤 Masatoshi Tsujino
- 👤 Tooru Ueda
- 👤 Tadashiro Fujii
- 👤 Satoshi Yaginuma
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 13:18
CPC Classifications
C; C07; C07D; C07D473/00; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6561; C07F9/65616; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/16; C07H19/20
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
3 words
2',3',5'-O-triacetyl neplanocin A.
Claim 2
Dependent Claim
3 words
2',3',5'-O-triacetyl neplanocin A.
Claim 3
Dependent Claim
3 words
2',3'-O-benzylidene neplanocin A.
Claim 4
Dependent Claim
3 words
2',3'-O-benzylidene neplanocin A.
Claim 5
Dependent Claim
8 words
N 6 , N 6 ,5'-O-tribenzoyl neplanocin A.
Claim 6
Dependent Claim
8 words
N 6 , N 6 ,5'-O-tribenzoyl neplanocin A.
Claim 7
Dependent Claim
5 words
N 6 ,5'-O-dibenzoyl neplanocin A.
Claim 8
Dependent Claim
5 words
N 6 ,5'-O-dibenzoyl neplanocin A.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-22 | 1990-03-24 | 1990-09-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-22 | 1994-03-24 | 1994-09-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-22 | 1998-03-24 | 1998-09-23 | $7700.00 | Window Closed / Lapsed |