US4613576A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Human monoclonal antibodies to cancer cells
Assignee: Memorial Sloan Kettering Cancer Center
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Filing: 1983-03-09
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Granted: 1986-09-23
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Expires: 2003-03-09
Abstract
Abstract Hybridomas which produce human monoclonal antibodies are disclosed. The hybridomas are formed by fusing lymphocytes from individuals with various cancers to an immortal cell line, such as a myeloma, from, e.g., a human cell line, or a mouse cell line.
Inventors
- 👤 Richard J. Cote
- 👤 Donna M. Morrissey
- 👤 Alan N. Houghton
- 👤 Edward J. Beattie, Jr.
- 👤 Herbert F. Oettgen
- 👤 Lloyd J. Old
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 19:33
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/30; C07K16/3023; C07K16/3015; C07K16/3038; C07K16/3061
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
23 words
Human monoclonal antibody producing hybridoma cell line where the product of said cell line specifically binds to cell surface antigen system HB 8223.
Claim 2
Dependent Claim
23 words
Human monoclonal antibody producing hybridoma cell line where the product of said cell line specifically binds to cell surface antigen system HB 8223.
Claim 3
Dependent Claim
26 words
Human monoclonal antibody producing hybridoma cell lines where the product of said cell lines specifically bind to intracellular antigens HB 8237, HB 8238 or HB 8239.
Claim 4
Dependent Claim
26 words
Human monoclonal antibody producing hybridoma cell lines where the product of said cell lines specifically bind to intracellular antigens HB 8237, HB 8238 or HB 8239.
Claim 5
Dependent Claim
22 words
Human monoclonal antibodies which specifically bind to cell surface antigen HB 8223 or intracellular antigens HB 8237, HB 8238, or HB 8239.
Claim 6
Dependent Claim
22 words
Human monoclonal antibodies which specifically bind to cell surface antigen HB 8223 or intracellular antigens HB 8237, HB 8238, or HB 8239.
Claim 7
Dependent Claim
64 words
An immunoassay for human cells comprising contracting said cells with at least one monoclonal antibody selected from the group consisting of HB 8223, HB 8237, HB 8238, HB 8239 under conditions favoring formation of an antigen:antibody complex between said antibody and an antigen or antigens to which said antibodies specifically bind, and observing the formation of said complex or the absence of said formation.
Claim 8
Dependent Claim
64 words
An immunoassay for human cells comprising contracting said cells with at least one monoclonal antibody selected from the group consisting of HB 8223, HB 8237, HB 8238, HB 8239 under conditions favoring formation of an antigen:antibody complex between said antibody and an antigen or antigens to which said antibodies specifically bind, and observing the formation of said complex or the absence of said formation.
Claim 9
Dependent Claim
10 words
Immunoassay of claim 4 with human monoclonal antibody HB 8223.
Claim 10
Dependent Claim
10 words
Immunoassay of claim 4 with human monoclonal antibody HB 8237.
Claim 11
Dependent Claim
10 words
Immunoassay of claim 4 with human monoclonal antibody HB 8238.
Claim 12
Dependent Claim
10 words
Immunoassay of claim 4 with human monoclonal antibody HB 8239.
Claim 13
Dependent Claim
15 words
Method of diagnosis of tumors comprising immunoassay of claim 4 of an excised human specimen.
Claim 14
Dependent Claim
31 words
Method of detecting cytoplasmic cytoskeletal perinuclear and nuclear components of human cells comprising immunoasay of claim 4 of said cells with human monoclonal antibody HB 8237, HB 8238, or HB 8239.
Claim 15
Dependent Claim
16 words
Panel of phenotyping human monoclonal antibodies comprising HB 8223, HB 8237, HB 8238, and HB 8239.
Claim 16
Dependent Claim
16 words
Panel of phenotyping human monoclonal antibodies comprising HB 8223, HB 8237, HB 8238, and HB 8239.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-22 | 1990-03-24 | 1990-09-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-22 | 1994-03-24 | 1994-09-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-22 | 1998-03-24 | 1998-09-23 | $7700.00 | Window Closed / Lapsed |