US4613330A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Delivery system for desired agents
Assignee: Individual
•
Filing: 1984-10-18
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Granted: 1986-09-23
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Expires: 2004-10-18
Abstract
Abstract A system for the controlled delivery of a desired agent to a fluid environment. A semipermeable container defines a fully enclosed cavity and is imperforate except for a plurality of pores for permitting fluid to flow from the fluid environment into the cavity. A quantity of a molecular complex is positioned in the cavity. The molecular complex comprises a macromolecule that is non-diffusable with respect to the container and a desired agent complexed to the macromolecule, the agent being capable of dissociating from the macromolecule over time. The pores of the container have a larger size in relation to the agent and the container is so constructed as to permit unimpeded passage of the agent through the pores. The concentration of the agent within the cavity is controlled by the equilibrium between the molecular complex and the agent within the cavity and the active agent is deliverable by the system to the fluid environment exclusively through the plurality of pores.
Inventors
- 👤 Paul E. Michelson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 22:01
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0048; A61K9/0051; A61F; A61F2/00; A61F2/02; A61F2/14; A61F2/16; A61F2/1613; A61F2/1616; G; G09; G09B; G09B23/00; G09B23/28; G09B23/30
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
158 words
A system for the controlled delivery of a desired agent to a fluid environment comprising: a semipermeable container defining a fully enclosed cavity and being imperforate except for a plurality of pores for permitting the flow of fluid between the fluid environment and said cavity; and a quantity of molecular complex positioned in said cavity, said molecular complex comprising a macromolecule that is nondiffusable with respect to said container and a desired agent complexed to said macromolecule, said agent being capable of dissociating from said macromolecule over time, said pores having a larger size in relation to said agent and said container being so constructed as to permit unimpeded passage of said agent through said pores, wherein the concentration of said agent within said cavity is controlled by the equilibrium between said molecular complex and said agent within said cavity and said agent is deliverable by said system to the fluid environment exclusively through said plurality of pores.
Claim 2
Independent Claim
158 words
A system for the controlled delivery of a desired agent to a fluid environment comprising: a semipermeable container defining a fully enclosed cavity and being imperforate except for a plurality of pores for permitting the flow of fluid between the fluid environment and said cavity; and a quantity of molecular complex positioned in said cavity, said molecular complex comprising a macromolecule that is nondiffusable with respect to said container and a desired agent complexed to said macromolecule, said agent being capable of dissociating from said macromolecule over time, said pores having a larger size in relation to said agent and said container being so constructed as to permit unimpeded passage of said agent through said pores, wherein the concentration of said agent within said cavity is controlled by the equilibrium between said molecular complex and said agent within said cavity and said agent is deliverable by said system to the fluid environment exclusively through said plurality of pores.
Claim 3
Dependent Claim
11 words
The system according to claim 1, wherein said container is biodegradable.
Claim 4
Dependent Claim
13 words
The system according to claim 1, wherein said container comprises a semipermeable sheath.
Claim 5
Dependent Claim
16 words
The system of claim 1, wherein said sheath has a thickness of less than 50 microns.
Claim 6
Dependent Claim
16 words
The system of claim 1, wherein the diameter of said pores is less than 1,000 Angstroms.
Claim 7
Dependent Claim
21 words
The system of claim 1, wherein said container has a pore density between 100 and 10 10 pores per square cm.
Claim 8
Dependent Claim
19 words
The system of claim 1, wherein said pores are sufficiently small to prevent the passage therethrough of said macromolecule.
Claim 9
Dependent Claim
15 words
The system of claim 1, wherein said container is transparent and said macromolecule is photostable.
Claim 10
Dependent Claim
10 words
The system of claim 1, wherein said macromolecule is inert.
Claim 11
Dependent Claim
24 words
The system of claim 1, wherein said macromolecule is selected from a group consisting of protein, cellulose, carbohydrates, rubber, high polymers and polymer arrays.
Claim 12
Dependent Claim
10 words
The system of claim 1, wherein said macromolecule is hydrophilic.
Claim 13
Dependent Claim
122 words
The system of claim 1, wherein said quantity of molecular complex constitutes a quantity of a first molecular complex with comprising a macromolecule of a first type complexed said desired agent, and said system further includes a quantity of a second molecular complex comprising a macromolecule of a second type that is nondiffusable with respect to said container and said desired agent complexed with said macromolecule of the second type, said desired agent being capable of dissociating from said macromolecule of the second type, and said first and second molecular complexes having different dissociation constants, wherein the concentration of said desired agent within said cavity is controlled by the equilibria between said desired agent and said first and second molecular complexes, respectively.
Claim 14
Dependent Claim
50 words
The system of claim 1, in combination with a fluid environment which contains a varying concentration of the desired agent, wherein the desired agent freely flows into and out of said cavity through said pores dependant upon the relative concentration of said agent within said cavity and in said environment.
Claim 15
Dependent Claim
75 words
The system of claim 1, in combination with a fluid environment which contains a second agent which can diffuse into said cavity through said pores for influencing the delivery of said desired agent to the environment, wherein said macromolecule is susceptible to competitive binding by said second agent and said second agent causes said desired agent to dissociate from said macromolecule and said second agent complexes with said macromolecule in place of said desired agent.
Claim 16
Dependent Claim
19 words
The system according to claim 1, wherein said desired agent is oxygen and said macromolecule complexes with oxygen molecules.
Claim 17
Dependent Claim
17 words
The system according to claim 1, wherein said macromolecule is hemoglobin and said desired agent is oxygen.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-22 | 1990-03-24 | 1990-09-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-22 | 1994-03-24 | 1994-09-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-22 | 1998-03-24 | 1998-09-23 | $7700.00 | Window Closed / Lapsed |