US4610962A
Expired / Lapsed
US
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Carriers for immobilization of physiologically active substances
Assignee: Unitika Ltd
•
Filing: 1984-06-01
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Granted: 1986-09-09
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Expires: 2004-06-01
Abstract
Abstract A carrier for immobilization of physiologically active substances is prepared by treating an assembly of regenerated cellulose fibers having a single fiber fineness of from 0.5 to 30 deniers and a length of at least 1 millimeter with a solution of a polymer having an acid anhydride group. This carrier is easy to handle and permits immobilization of a large amount of a physiologically active substance. Thus it can be used as a catalyst for chemical reactions, a specific absorbent for separation and purification, a material for clinical examination, or a medical material.
Inventors
- 👤 Kunihiko Takagi
- 👤 Masatsugu Mochizuki
- 👤 Izumi Sakamoto
- 👤 Hiroichi Teranishi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 18:49
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/02; C12N11/10; C12N11/12; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/544; G01N33/548; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2913; Y10T428/2933; Y10T428/2938; Y10T428/31504; Y10T428/31855; Y10T428/3188; Y10T428/31884; Y10T428/31891; Y10T428/31942; Y10T428/31949; Y10T428/31953; Y10T428/31971; Y10T428/31993
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
49 words
A carrier for immobilization of physiologically active substances which is prepared by treating an assembly of regenerated cellulose fibers having a single fiber fineness of from 0.5 to 30 deniers and a length of at least 1 millimeter with a solution of a polymer having an acid anhydride group.
Claim 2
Dependent Claim
49 words
A carrier for immobilization of physiologically active substances which is prepared by treating an assembly of regenerated cellulose fibers having a single fiber fineness of from 0.5 to 30 deniers and a length of at least 1 millimeter with a solution of a polymer having an acid anhydride group.
Claim 3
Dependent Claim
17 words
A carrier as in claim 1, wherein the single fiber fineness is from 1 to 20 deniers.
Claim 4
Dependent Claim
14 words
A carrier as in claim 1, wherein the length is at least 5 millimeters.
Claim 5
Dependent Claim
27 words
A carrier as in claim 1, wherein the acid anhydride group content per gram of the carrier (calculated as carboxyl group) is from 0.0002 to 20 milliequivalents.
Claim 6
Dependent Claim
45 words
A carrier as in claim 1, wherein the single fiber fineness is from 1 to 20 deniers, the length is at least 5 millimeters, and the acid anhydride group content per gram of the carrier (calculated as carboxyl group) is from 0.0002 to 20 milliequivalents.
Claim 7
Dependent Claim
14 words
A carrier as in claim 1, wherein the length is at least 20 millimeters.
Claim 8
Dependent Claim
14 words
A carrier as in claim 5, wherein the length is at least 20 millimeters.
Claim 9
Dependent Claim
22 words
A carrier as in claim 1, wherein the polymer having an acid anhydride group is a poly(carboxylic anhydride) or a copolymer thereof.
Claim 10
Dependent Claim
42 words
A carrier as in claim 8, wherein the copolymer is copolymers of maleic anhydride and aliphatic vinyl ethers, copolymers of maleic anhydride and olefin monomers, copolymers of maleic anhydride and aromatic vinyl monomers and copolymers of maleic anhydride and aliphatic vinyl esters.
Claim 11
Dependent Claim
56 words
A carrier as in claim 9, wherein the copolymer is selected from the group consisting of a maleic anhydride/methyl vinyl ether copolymer, a maleic anhydride/ethyl vinyl ether copolymer, a maleic anhydride/butanediol divinyl ether copolymer, a maleic anhydride/ethylene copolymer, a maleic anhydride/propylene copolymer, a maleic anhydride/isobutylene copolymer, a maleic anhydride/styrene copolymer, and a maleic anhydride/vinyl acetate copolymer.
Claim 12
Dependent Claim
26 words
A carrier as in claim 8, wherein the poly(carboxylic anhydride) is selected from the group consisting of poly(maleic anhydride), poly(itaconic anhydride), poly(acrylic anhydride) and poly(methacrylic anhydride).
Claim 13
Dependent Claim
57 words
A carrier as in claim 1, wherein the polymer having an acid anhydride group is dissolved in one or more solvents selected from the group consisting of methanol, ethanol, propanol, isopropanol, butanol, tetrahydrofuran, ethyl acetate, methyl acetate, benzaldehyde, formaldehyde, acetone, cyclohexanone, methyl ethyl ketone, mesytil oxide, diacetone alcohol, 2-pyrrolidone, N-methyl-2-pyrrolidone, N-vinyl-2-pyrrolidone, butyralactone, acetic acid, dimethylformamide, and pyridine.
Claim 14
Dependent Claim
31 words
A carrier as in claim 12, wherein the concentration of the polymer having an acid anhydride group is from 0.1 to 30% by weight based on the weight of the solution.
Claim 15
Dependent Claim
31 words
A carrier as in claim 12, wherein the concentration of the polymer having an acid anhydride group is from 0.5 to 10% by weight based on the weight of the solution.
Claim 16
Dependent Claim
27 words
A carrier as in claim 1, wherein the assembly of regenerated cellulose fibers is treated with the solution at a temperature of from 0° to 150° C.
Claim 17
Dependent Claim
27 words
A carrier as in claim 1, wherein the assembly of regenerated cellulose fibers is treated with the solution at a temperature of from 0° to 100° C.
Claim 18
Dependent Claim
27 words
A carrier as in claim 1, wherein the assembly of regenerated cellulose fibers is treated with the solution at a temperature of from 20° to 80° C.
Claim 19
Dependent Claim
32 words
A carrier as in claim 1, wherein the treatment of the assembly of regenerated cellulose fibers with the solution is carried out for period of from about 10 minutes to 72 hours.
Claim 20
Dependent Claim
32 words
A carrier as in claim 1, wherein the treatment of the assembly of regenerated cellulose fibers with the solution is carried out for period of from about 30 minutes to 36 hours.
Claim 21
Dependent Claim
27 words
A carrier as in claim 1, wherein the acid anhydride group content per gram of the carrier (calculated as carboxyl group) is from 0.002 to 10 milliequivalents.
Claim 22
Dependent Claim
27 words
A carrier as in claim 1, wherein the acid anhydride group content per gram of the carrier (calculated as carboxyl group) is from 0.02 to 5 milliequivalents.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-08 | 1990-03-10 | 1990-09-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-08 | 1994-03-10 | 1994-09-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-08 | 1998-03-10 | 1998-09-09 | $7700.00 | Window Closed / Lapsed |