US4609725A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cardiac atrial peptides
Assignee: Merck and Co Inc
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Filing: 1984-10-09
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Granted: 1986-09-02
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Expires: 2004-10-09
Abstract
Abstract Monoiodinated-tyrosine derivatives of synthetic fragments of mammalian atrial natriuretic factor are biologically active and are useful to determine the mode of biological activity and the effect of derivatization on biological activity.
Inventors
- 👤 Stephen F. Brady
- 👤 Mary A. Napier
- 👤 Ruth F. Nutt
- 👤 Richard L. Vandlen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 19:07
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/58; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
65 words
A peptide comprising one of the amino acid sequences: A-Cys-Phe-Gly-Gly-Arg-X-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-(I-Tyr)-B wherein X is Ile or Met, A is absent or present and if present is: ##STR2## and B is absent or present and if present is -Arg or -Arg-Arg, and wherein the I atom is nonradioactive or radioactive and the peptide is linear or cyclized by means of covalent bonds between the two cysteine residues.
Claim 2
Dependent Claim
65 words
A peptide comprising one of the amino acid sequences: A-Cys-Phe-Gly-Gly-Arg-X-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-(I-Tyr)-B wherein X is Ile or Met, A is absent or present and if present is: ##STR2## and B is absent or present and if present is -Arg or -Arg-Arg, and wherein the I atom is nonradioactive or radioactive and the peptide is linear or cyclized by means of covalent bonds between the two cysteine residues.
Claim 3
Dependent Claim
9 words
A peptide of claim 1 wherein X is Ile.
Claim 4
Dependent Claim
9 words
A peptide of claim 1 wherein X is Met.
Claim 5
Dependent Claim
16 words
A peptide of claim 1 wherein X is Ile, A is Arg-Arg-Ser-Ser and B is absent.
References Cited (Backward Citations)
US4460559A
Cited
US4448764A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-01 | 1990-03-03 | 1990-09-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-01 | 1994-03-03 | 1994-09-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-01 | 1998-03-03 | 1998-09-02 | $7700.00 | Window Closed / Lapsed |