US4609650A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Double ester of 16β-ethylestran-17β-ol derivatives
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1984-03-27
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Granted: 1986-09-02
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Expires: 2004-03-27
Abstract
Abstract A novel steroid compound of the formula ##STR1## wherein A is a lower alkylene group; ##STR2## is an acyl group; and is a single bond or a double bond, and methods of producing the compound (I) as follows: ##STR3## and a pharmaceutical composition containing the compound (I). The compound (I) exhibits excellent antiandrogenic activity on oral administration and can be used for the treatment of prostatic hypertrophy.
Inventors
- 👤 Yoshinobu Yoshimura
- 👤 Yoko Nishida
- 👤 Takatsuka Yashiki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 15:35
CPC Classifications
C; C07; C07J; C07J41/00; C07J41/0033; C07J41/0044; C07J1/00; C07J1/0051; C07J1/0066; C07J1/007; C07J1/0074
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
28 words
A steroid compound of the formula: ##STR24## wherein A is a lower alkylene group; ##STR25## is an acyl group; and means a single bond or a double bond.
Claim 2
Dependent Claim
28 words
A steroid compound of the formula: ##STR24## wherein A is a lower alkylene group; ##STR25## is an acyl group; and means a single bond or a double bond.
Claim 3
Dependent Claim
118 words
A compound as claimed in claim 1, which is a compound of the formula: ##STR26## wherein A 1 is a straight-chain or branched alkylene group of 1 to 6 carbon atoms, R 1 is (1) hydrogen, (2) a straight-chain or branched alkyl group of 1 to 17 carbon atoms which may be substituted by hydroxyl, carboxyl, cycloalkyl of 3 to 8 carbon atoms, amino, t-butoxycarbonylamino, mercapto or oxo group, (3) a cycloalkyl group of 3 to 8 carbon atoms, (4) an aryl group of 6 to 10 carbon atoms or (5) an aralkyl group of 7 to 11 carbon atoms which may be substituted by hydroxyl, carboxyl or amino, and means a single bond or a double bond.
Claim 4
Dependent Claim
89 words
A compound as claimed in claim 1, which is a compound of the formula: ##STR27## wherein A 2 is a straight-chain or branched alkylene group of 1 to 3 carbon atoms, R 2 is (i) a straight-chain or branched alkyl group of 1 to 17 carbon atoms, (ii) a straight-chain or branched alkyl group of 1 to 6 carbon atoms which is substituted by hydroxyl, carboxyl, cyclopentyl, cyclohexyl, t-butoxycarbonylamino or oxo, (iii) cyclopentyl, (iv) cyclohexyl, (v) phenyl or (vi) α-hydroxybenzyl, and means a single bond or a double bond.
Claim 5
Dependent Claim
40 words
A compound as claimed in claim 1, which is a compound of the formula: ##STR28## wherein R 3 is a straight-chain or branched alkyl group of 5 or 6 carbon atoms and means a single bond or a double bond.
Claim 6
Dependent Claim
12 words
A compound as claimed in claim 1, which is 16β-ethyl-17β-n-hexanoyloxyacetoxy-4-estren-3-one or 16β-ethyl-17β-(2-ethylbutyryl)oxyacetoxy-4-estren-3-one.
Claim 7
Dependent Claim
10 words
A compound as claimed in claim 1, which is 16β-ethyl-17β-n-hexanoyloxyacetoxy-4,9(10)-estradien-3-one.
Claim 8
Dependent Claim
32 words
A pharmaceutical preparation containing a steroid compound of the formula: ##STR29## wherein A is a lower alkylene group; ##STR30## is an acyl group; and means a single bond or a double bond.
Claim 9
Dependent Claim
32 words
A pharmaceutical preparation containing a steroid compound of the formula: ##STR29## wherein A is a lower alkylene group; ##STR30## is an acyl group; and means a single bond or a double bond.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-01 | 1990-03-03 | 1990-09-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-01 | 1994-03-03 | 1994-09-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-01 | 1998-03-03 | 1998-09-02 | $7700.00 | Window Closed / Lapsed |