US4609372A
Expired / Lapsed
US
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Heat sterilizable storage solution for red blood cells
Assignee: Bayer Corp
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Filing: 1983-10-13
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Granted: 1986-09-02
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Expires: 2003-10-13
Abstract
Abstract Aqueous storage solution for red blood cells comprising a stabilized ascorbate derivative and having a pH sufficient to maintain substantially all of the initial concentration of ascorbate derivative and avoid formation of ascorbate degradation products during heat sterilization. A preferred solution includes at least about 90% of the pre-sterilization ascorbate and adenine but is free of dextrose.
Inventors
- 👤 Raleigh A. Carmen
- 👤 Chiyong Chong
- 👤 Barry Leng
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 13:41
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/14; A01N1/146; A61; A61M; A61M1/00; A61M1/02; A61M1/0209
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
44 words
A heat sterilized aqueous solution for storage of red blood cells comprising a stabilized ascorbate derivative, the solution having a pH greater than about 8.0 and sufficient to maintain substantially all of the initial amount of ascorbate derivative during heat sterilization of the composition.
Claim 2
Dependent Claim
44 words
A heat sterilized aqueous solution for storage of red blood cells comprising a stabilized ascorbate derivative, the solution having a pH greater than about 8.0 and sufficient to maintain substantially all of the initial amount of ascorbate derivative during heat sterilization of the composition.
Claim 3
Dependent Claim
21 words
The solution of claim 1 wherein the amount of ascorbate derivative is at least about 90% of its pre-heat sterilization amount.
Claim 4
Dependent Claim
14 words
The solution of claim 1, wherein the stabilized ascorbate derivative is an ascorbate phosphate.
Claim 5
Dependent Claim
22 words
The solution of claim 3 wherein the ascorbate derivative is selected from the group consisting of ascorbate-2-phosphate, ascorbate-3-phosphate and ascorbate 2,2' phosphate.
Claim 6
Dependent Claim
10 words
The solution of claim 1 wherein the solution includes adenine.
Claim 7
Dependent Claim
11 words
The solution of claim 1 wherein the solution includes inorganic phosphate.
Claim 8
Dependent Claim
32 words
The solution of claim 1 wherein substantially all of the initial amount of ascorbate derivative is maintained after heat sterilization at at least about 114° C. for at least about 30 minutes.
Claim 9
Dependent Claim
69 words
A multiple blood bag system comprising a donor bag for receiving blood from a donor and a satellite blood bag connected via tubing to the donor bag and containing an aqueous solution of a stabilized ascorbate derivative having a pH greater than about 8.0 and sufficient to maintain the amount of ascorbate derivative at a level of about 90% or more by weight during heat sterilization of the solution.
Claim 10
Dependent Claim
69 words
A multiple blood bag system comprising a donor bag for receiving blood from a donor and a satellite blood bag connected via tubing to the donor bag and containing an aqueous solution of a stabilized ascorbate derivative having a pH greater than about 8.0 and sufficient to maintain the amount of ascorbate derivative at a level of about 90% or more by weight during heat sterilization of the solution.
Claim 11
Dependent Claim
15 words
The multiple blood bag system of claim 8 wherein said donor bag contains an anticoagulant.
Claim 12
Dependent Claim
17 words
The combination of claim 8 wherein the pH of the red cell storage composition is about 8.5-9.5.
Claim 13
Dependent Claim
17 words
The multiple blood bag system of claim 8 wherein the solution is substantially free of a sugar.
Claim 14
Dependent Claim
16 words
The multiple blood bag system of claim 8 wherein the stabilized ascorbate derivative is ascorbate phosphate.
Claim 15
Dependent Claim
25 words
The multiple blood bag system of claim 12 wherein the ascorbate derivative is selected from the group consisting of ascorbate-2-phosphate, ascorbate-3-phosphate and ascorbate 2,2' phosphate.
Claim 16
Dependent Claim
13 words
The multiple blood bag system of claim 8 wherein the solution includes adenine.
Claim 17
Dependent Claim
32 words
A multiple blood bag system, as claimed in claim 8, wherein the ascorbate derivative level is maintained after heat sterilization at at least about 114° C. for at least about 30 minutes.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-01 | 1990-03-03 | 1990-09-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-01 | 1994-03-03 | 1994-09-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-01 | 1998-03-03 | 1998-09-02 | $7700.00 | Window Closed / Lapsed |