US4608200A
Expired / Lapsed
US
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Chloramphenicol derivatives, antigens and antibodies
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1984-11-30
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Granted: 1986-08-26
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Expires: 2004-11-30
Abstract
Abstract Chloramphenicol derivatives are provided for use in the preparing of antigen conjugates for the production of antibodies specifically for chloramphenicol. Specifically, the aryl amino group is derivatized to introduce a non-oxo-carbonyl group which is used for amide formation with an antigen. The conjugate is then injected into a vertebrate for production of antisera which is isolated in conventional ways and find particular use in competitive protein binding assays.
Inventors
- 👤 Pyare L. Khanna
- 👤 Evan S. Snyder
- 👤 Prithipal Singh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 12:30
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/94; G01N33/9446; Y; Y10; Y10S; Y10S436/00; Y10S436/822; Y10S436/823; Y10S530/00; Y10S530/807
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
68 words
Antibodies prepared in response to an antigen of the formula: ##STR4## wherein: m is 0 or 1 R is a saturated aliphatic linking group of from 2 to 6 carbon atoms having from 0 to 1 oxo-carbonyl group at its terminus bonded to nitrogen; Y 1 is a poly(amino acid); and n 1 is a number from one to the molecular weight of Y 1 divided by 2000.
Claim 2
Dependent Claim
68 words
Antibodies prepared in response to an antigen of the formula: ##STR4## wherein: m is 0 or 1 R is a saturated aliphatic linking group of from 2 to 6 carbon atoms having from 0 to 1 oxo-carbonyl group at its terminus bonded to nitrogen; Y 1 is a poly(amino acid); and n 1 is a number from one to the molecular weight of Y 1 divided by 2000.
Claim 3
Dependent Claim
23 words
A compound according to claim 6 wherein R has an oxo-carbonyl at its terminus bonded to nitrogen and is of 3 carbon atoms.
Claim 4
Dependent Claim
67 words
A compound of the formula: ##STR5## wherein: R is a saturated aliphatic linking group of from 2 to 8 carbon atoms wherein the atom at the terminus bonded to nitrogen is saturated; Y 2 is hydrogen, hydroxyl, alkoxyl from 1 to 6 carbon atoms, or a group forming an acitvated ester cable of amide formation in an aqueous medium; m is 1; and n 2 is 1.
Claim 5
Dependent Claim
67 words
A compound of the formula: ##STR5## wherein: R is a saturated aliphatic linking group of from 2 to 8 carbon atoms wherein the atom at the terminus bonded to nitrogen is saturated; Y 2 is hydrogen, hydroxyl, alkoxyl from 1 to 6 carbon atoms, or a group forming an acitvated ester cable of amide formation in an aqueous medium; m is 1; and n 2 is 1.
Claim 6
Dependent Claim
71 words
A compound of the formula: ##STR6## wherein: R is an aliphatic linking group of up to 12 atoms other than hydrogen having a chain of from 2 to 8 atoms consisting of carbon, nitrogen, and chalcogen of atomic no. 8 to 16 selected from the group consisting of alkylene, alkenylene, alkyleneoxyalkylene and alkyleneaminoalkylene; Z 1 is alkoxyl of from 1 to 6 carbon atoms; m is 1; and n is 1.
Claim 7
Dependent Claim
71 words
A compound of the formula: ##STR6## wherein: R is an aliphatic linking group of up to 12 atoms other than hydrogen having a chain of from 2 to 8 atoms consisting of carbon, nitrogen, and chalcogen of atomic no. 8 to 16 selected from the group consisting of alkylene, alkenylene, alkyleneoxyalkylene and alkyleneaminoalkylene; Z 1 is alkoxyl of from 1 to 6 carbon atoms; m is 1; and n is 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-25 | 1990-02-24 | 1990-08-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-25 | 1994-02-24 | 1994-08-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-25 | 1998-02-24 | 1998-08-26 | $7700.00 | Window Closed / Lapsed |