Patent US6756577B2 successfully refreshed from Google Patents.
US4608149A
Expired / Lapsed
US
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Potassium ion-selective compositions and electrodes containing same
Assignee: Clinical Diagnostic Systems Inc
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Filing: 1985-09-30
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Granted: 1986-08-26
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Expires: 2005-09-30
Abstract
Abstract Potassium ion-selective compositions which comprise valinomycin and a particular carrier solvent capable of solvating valinomycin are disclosed. The carrier solvent is a dicarboxylic acid diester having at least 25 carbon atoms, a viscosity of less than about 120 centipoise at 20 DEG C. and a boiling point greater than about 170 DEG C. at 5 mm pressure. A preferred carrier solvent is diisodecyl phthalate. Membranes prepared from these compositions preferably have a glass transition temperature greater than about -50 DEG C. These membranes are particularly useful in dry-operative potassium ion-selective electrodes which are capable of selectively determining potassium ions in preference to other ions.
Inventors
- 👤 Daniel S. Daniel
- 👤 Thomas R. Kissel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 22:37
CPC Classifications
G; G01; G01N; G01N27/00; G01N27/26; G01N27/28; G01N27/30; G01N27/333; G01N27/3335; G01N2410/00; G01N2410/10
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
9 words
A potassium ion-selective composition comprising valinomycin and diisodecyl phthalate.
Claim 2
Dependent Claim
9 words
A potassium ion-selective composition comprising valinomycin and diisodecyl phthalate.
Claim 3
Dependent Claim
8 words
The composition of claim 1 comprising a surfactant.
Claim 4
Dependent Claim
10 words
The composition of claim 1 comprising a hydrophobic polymer binder.
Claim 5
Dependent Claim
12 words
A potassium ion-selective composition comprising valinomycin, diisodecyl phthalate and poly(vinyl chloride-co-vinyl acetate).
Claim 6
Dependent Claim
12 words
A potassium ion-selective composition comprising valinomycin, diisodecyl phthalate and poly(vinyl chloride-co-vinyl acetate).
Claim 7
Dependent Claim
49 words
A dry-operative potassium ion-selective electrode comprising valinomycin dissolved in a dicarboxylic acid diester capable of solvating valinomycin, said diester having at least 25 carbon atoms, a viscosity of less than about 120 centipoise at 20° C. and a boiling point greater than about 170° C. at 5 mm pressure.
Claim 8
Dependent Claim
49 words
A dry-operative potassium ion-selective electrode comprising valinomycin dissolved in a dicarboxylic acid diester capable of solvating valinomycin, said diester having at least 25 carbon atoms, a viscosity of less than about 120 centipoise at 20° C. and a boiling point greater than about 170° C. at 5 mm pressure.
Claim 9
Dependent Claim
18 words
The electrode of claim 5 wherein said valinomycin and said diester are distributed within a hydrophobic polymer binder.
Claim 10
Dependent Claim
117 words
A dry-operative potassium ion-selective electrode comprising: (a) a dried internal reference element comprising the dried residue of a solution of a salt and a hydrophilic polymeric binder in a solvent for the polymer and the salt and, (b) in physical contact with said reference element, a hydrophobic ion-selective membrane of predetermined uniform thickness in regions thereof intended for physical contact with a sample for analysis, the membrane comprising a hydrophobic polymeric binder having distributed therein valinomycin dissolved in a sebacate, phthalate or adipate capable of solvating valinomycin and having at least 25 carbon atoms, a viscosity less than about 120 centipoise at 20° C. and a boiling point greater than about 170° C. at 5 mm pressure.
Claim 11
Dependent Claim
117 words
A dry-operative potassium ion-selective electrode comprising: (a) a dried internal reference element comprising the dried residue of a solution of a salt and a hydrophilic polymeric binder in a solvent for the polymer and the salt and, (b) in physical contact with said reference element, a hydrophobic ion-selective membrane of predetermined uniform thickness in regions thereof intended for physical contact with a sample for analysis, the membrane comprising a hydrophobic polymeric binder having distributed therein valinomycin dissolved in a sebacate, phthalate or adipate capable of solvating valinomycin and having at least 25 carbon atoms, a viscosity less than about 120 centipoise at 20° C. and a boiling point greater than about 170° C. at 5 mm pressure.
Claim 12
Dependent Claim
18 words
The electrode of claim 7 wherein said membrane has a glass transition temperature greater than about -50° C.
Claim 13
Dependent Claim
11 words
The electrode of claim 8 wherein said diester is a phthalate.
Claim 14
Dependent Claim
11 words
The electrode of claim 9 wherein said diester is diisodecyl phthalate.
Claim 15
Dependent Claim
11 words
The electrode of claim 7 wherein said membrane comprises a surfactant.
Claim 16
Dependent Claim
92 words
A dry operative potassium ion-selective electrode comprising: (a) a dried internal reference element comprising the dried residue of a solution of a salt and a hydrophilic polymeric binder in a solvent for the polymer and the salt and, (b) in physical contact with said reference element, a hydrophobic ion-selective membrane of predetermined uniform thickness in regions thereof intended for physical contact with a sample for analysis, the membrane having a glass transition temperature of greater than about -50° C. and comprising poly(vinyl chloride-co-vinyl alcohol) having distributed therein valinomycin dissolved in diisodecyl phthalate.
Claim 17
Dependent Claim
92 words
A dry operative potassium ion-selective electrode comprising: (a) a dried internal reference element comprising the dried residue of a solution of a salt and a hydrophilic polymeric binder in a solvent for the polymer and the salt and, (b) in physical contact with said reference element, a hydrophobic ion-selective membrane of predetermined uniform thickness in regions thereof intended for physical contact with a sample for analysis, the membrane having a glass transition temperature of greater than about -50° C. and comprising poly(vinyl chloride-co-vinyl alcohol) having distributed therein valinomycin dissolved in diisodecyl phthalate.
Claim 18
Dependent Claim
23 words
A potassium ion-selective composition comprising valinomycin and a carrier solvent selected from the group consisting of diisodecyl phthalate, bis(2-ethylhexyl) sebacate and diisodecyl adipate.
Claim 19
Dependent Claim
23 words
A potassium ion-selective composition comprising valinomycin and a carrier solvent selected from the group consisting of diisodecyl phthalate, bis(2-ethylhexyl) sebacate and diisodecyl adipate.
Claim 20
Dependent Claim
25 words
A dry-operative potassium ion-selective electrode comprising valinomycin dissolved in a carrier solvent selected from the group consisting of diisodecyl phthalate, bis(2-ethylhexyl) sebacate and diisodecyl adipate.
Claim 21
Dependent Claim
25 words
A dry-operative potassium ion-selective electrode comprising valinomycin dissolved in a carrier solvent selected from the group consisting of diisodecyl phthalate, bis(2-ethylhexyl) sebacate and diisodecyl adipate.
Claim 22
Dependent Claim
17 words
The electrode of claim 14 wherein said valinomycin and carrier solvent are distributed within a hydrophobic binder.
Claim 23
Dependent Claim
13 words
The electrode of claim 15 wherein said hydrophobic binder is poly(vinyl chloride-co-vinyl acetate).
References Cited (Backward Citations)
US4276141A
Cited
US4476007A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-25 | 1990-02-24 | 1990-08-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-25 | 1994-02-24 | 1994-08-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-25 | 1998-02-24 | 1998-08-26 | $7700.00 | Window Closed / Lapsed |