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US4604286A Expired / Lapsed US ⏱️ 0.0 years remaining

Infusion solution for parenteral nutrition

Assignee: Daigo Nutritive Chemicals Ltd
•
Filing: 1984-09-17
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Granted: 1986-08-05
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Expires: 2004-09-17
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Abstract

Abstract Infusion solutions for parenteral nutrition which contain amino acids, dextrose and electrolytes.

Inventors

  • 👤 Seizo Kawajiri

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-24 03:46
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/42

Claims Analysis

Total Claims: 4
Claim 1
Independent Claim 223 words
An aqueous infusion solution for parenteral nutrition containing dextrose, amino acids and electrolytes in the form of salts of sodium, potassium, magnesium, calcium, phosphate and chlorine in the solution, wherein the pH of the solution is 4.5-5.5, said compounds being in the form of salts with hydrochloric acid, phosphoric acid, sulfuric acid and latic acid, the pH adjustment is effected by the use of an acid selected from the group consisting of hydrochloric acid, phosphoric acid, sulfuric acid and lactic acid, the content of dextrose is 3-10 W/V %, the content of amino acids is as follows: ______________________________________ Amino acid Concentration (g/l) ______________________________________ L-Methionine 1.09-3.27 L-Isoleucine 1.61-4.83 L-Leucine 2.02-6.06 L-Phenylalanine 1.12-3.36 L-Valine 1.45-4.35 L-Threonine 0.81-2.43 L-Lysine.HCl 1.46-4.38 L-Tryptophan 0.32-0.96 L-Alanine 0-4.59 L-Arginine 0-5.76 L-Histidine 0-1.74 L-Proline 0-6.78 L-Serine 0-3.60 Amino acetic acid 0-7.80 L-Cysteine HCl 0.0.09 ______________________________________ and the concentrations (as mEq/1) of the electrolytes including the acids used for the pH adjustment and f the hydrochlorides, if any, of the amino acid(s) are as follows: ______________________________________ Na.sup.+ 30-60 K.sup.+ 20-35 Mg.sup.+ 0-5 Ca.sup.++ 0-5 HPO.sub.4.sup.-- 0-10 Cl.sup.- 30-70 SO.sub.4.sup.-- 0-5 ______________________________________ and said solution further containing at least one of sodium lactate, calcium lactate or lactic acid in a concentration of 10-50 mEq/1 and said solution being free from any organic acid or its salt other than lactic acid or is salt.
Claim 2
Dependent Claim 223 words
An aqueous infusion solution for parenteral nutrition containing dextrose, amino acids and electrolytes in the form of salts of sodium, potassium, magnesium, calcium, phosphate and chlorine in the solution, wherein the pH of the solution is 4.5-5.5, said compounds being in the form of salts with hydrochloric acid, phosphoric acid, sulfuric acid and latic acid, the pH adjustment is effected by the use of an acid selected from the group consisting of hydrochloric acid, phosphoric acid, sulfuric acid and lactic acid, the content of dextrose is 3-10 W/V %, the content of amino acids is as follows: ______________________________________ Amino acid Concentration (g/l) ______________________________________ L-Methionine 1.09-3.27 L-Isoleucine 1.61-4.83 L-Leucine 2.02-6.06 L-Phenylalanine 1.12-3.36 L-Valine 1.45-4.35 L-Threonine 0.81-2.43 L-Lysine.HCl 1.46-4.38 L-Tryptophan 0.32-0.96 L-Alanine 0-4.59 L-Arginine 0-5.76 L-Histidine 0-1.74 L-Proline 0-6.78 L-Serine 0-3.60 Amino acetic acid 0-7.80 L-Cysteine HCl 0.0.09 ______________________________________ and the concentrations (as mEq/1) of the electrolytes including the acids used for the pH adjustment and f the hydrochlorides, if any, of the amino acid(s) are as follows: ______________________________________ Na.sup.+ 30-60 K.sup.+ 20-35 Mg.sup.+ 0-5 Ca.sup.++ 0-5 HPO.sub.4.sup.-- 0-10 Cl.sup.- 30-70 SO.sub.4.sup.-- 0-5 ______________________________________ and said solution further containing at least one of sodium lactate, calcium lactate or lactic acid in a concentration of 10-50 mEq/1 and said solution being free from any organic acid or its salt other than lactic acid or is salt.
Claim 3
Dependent Claim 55 words
The aqueous solution according to claim 1 wherein the content of amino acids is as follows: ______________________________________ Amino Acid Concentration (g/l) ______________________________________ L-Methionine 1.64-2.18 L-Isoleucine 2.42-3.22 L-Leucine 3.03-4.04 L-Phenylalanine 1.68-2.24 L-Valine 2.17-2.90 L-Threonine 1.22-1.62 L-Lysine.HCl 2.19-2.92 L-Tryptophan 0.48-0.64 L-Alanine 2.29-3.06 L-Arginine 2.88-3.84 L-Histidine 0.87-1.16 L-Proline 3.39-4.52 L-Serine 1.80-2.40 Amino acetic acid 3.90-5.20 L-Cysteine.HCl 0.04-0.06 ______________________________________
Claim 4
Dependent Claim 58 words
The aqueous solution according to claim 1 which further contains a stabilizer selected from the group consisting of NaHSO 3 , Na 2 S 2 O 5 , Na 2 SO 3 , KHSO 3 , K 2 S 2 O 5 and K 2 SO 3 in an amount of up to 0.04 to 0.05 W/V %.

References Cited (Backward Citations)

US3773930A Cited
US4025650A Cited
US4279917A Cited
US4368204A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1989-08-04 1990-02-03 1990-08-05 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1993-08-04 1994-02-03 1994-08-05 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1997-08-04 1998-02-03 1998-08-05 $7700.00 Window Closed / Lapsed

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