US4603197A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Mannoglucan derivatives
Assignee: Daiichi Pharmaceutical Co Ltd
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Filing: 1983-12-28
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Granted: 1986-07-29
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Expires: 2003-12-28
Abstract
Abstract Mannoglucan derivatives wherein from about 2 to 51 per 100 of side chain alpha -D-mannopyranosyl residues of mannoglucan have been cleaved and reduced to polyhydroxy residues possess antitumor activity with reduced pyrogenecity.
Inventors
- 👤 Shizuo Kadoya
- 👤 Kazuhiro Inoue
- 👤 Morihiro Kohno
- 👤 Hidemasa Ogawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 22:03
CPC Classifications
C; C08; C08B; C08B37/00; A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61P; A61P35/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
74 words
A mannoglucan derivative comprising a basic repeating unit represented by the formula: ##STR6## wherein X and Y each represent ##STR7## and the ratio of the total number of the groups A and B to the number of the group M, (A+B)/M, is in the range of from 2/98 to 51/49, wherein said mannoglucan derivative has a molecular weight peak of from 850,000±90,000 to 1,200,000±120,000, as determined by gel-permeation chromatography with dextran as a standard.
Claim 2
Dependent Claim
74 words
A mannoglucan derivative comprising a basic repeating unit represented by the formula: ##STR6## wherein X and Y each represent ##STR7## and the ratio of the total number of the groups A and B to the number of the group M, (A+B)/M, is in the range of from 2/98 to 51/49, wherein said mannoglucan derivative has a molecular weight peak of from 850,000±90,000 to 1,200,000±120,000, as determined by gel-permeation chromatography with dextran as a standard.
Claim 3
Dependent Claim
20 words
A mannoglucan derivative as claimed in claim 1, wherein up to 2% of the unsubstituted (1→4)-linked D-glucosyl residues are polyhydroxylated.
Claim 4
Dependent Claim
58 words
A mannoglucan derivative as claimed in claim 1 which shows elemental analysis values of C: 41 to 44%; H: 6 to 7%; and N: 0 to 0.4%, and a specific rotatory power [α] D 25 (c=0.5, water) of +15°±5° to 60°±10°, and is soluble in water and practically insoluble in methanol, ethanol, ethyl acetate, acetone and diethyl ether.
Claim 5
Dependent Claim
46 words
A mannoglucan derivative as claimed in claim 1, wherein the (A+B)/M ratio is 2/98, the molecular weight peak is 920,000±90,000, the elemental analysis values are C: 41.9%; H: 6.1%; and N: 0 to 0.4%, and the specific rotatory power [α] D 25 (c=0.5, water) is +60°±10°.
Claim 6
Dependent Claim
46 words
A mannoglucan derivative as claimed in claim 1, wherein the (A+B)/M ratio is 9/91, the molecular weight peak is 1,050,000±100,000, the elemental analysis values are C: 42.1%; H: 6.1%; and N: 0 to 0.4%, and the specific rotatory power [α] D 25 (c=0.5, water) is +51°±10°.
Claim 7
Dependent Claim
46 words
A mannoglucan derivative as claimed in claim 1, wherein the (A+B)/M ratio is 31/69, the molecular weight peak is 1,200,000±120,000, the elemental analysis values are C: 42.4%; H: 6.2%; and N: 0 to 0.4%, and the specific rotatory power [α] D 25 (c=0.5, water) is +30°±5°.
Claim 8
Dependent Claim
46 words
A mannoglucan derivative as claimed in claim 1, wherein the (A+B)/M ratio is 51/49, the molecular weight peak is 850,000+90,000, the elemental analysis values are C: 42.1%; H: 6.2%; and N: 0 to 0.4%, and the specific rotatory power [α] D 25 (c=0.5, water) is +15°±5°.
References Cited (Backward Citations)
US4398023A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-07-28 | 1990-01-27 | 1990-07-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-07-28 | 1994-01-27 | 1994-07-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-07-28 | 1998-01-27 | 1998-07-29 | $7700.00 | Window Closed / Lapsed |