US4603112A
Expired / Lapsed
US
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Modified vaccinia virus
Assignee: Health Research Inc
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Filing: 1982-12-08
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Granted: 1986-07-29
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Expires: 2002-12-08
Abstract
Abstract What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms involved as intermediates in such methods; and methods for infecting cells and host animals with such vaccinia mutants to provoke the amplification of exogenous DNA and proteins encoded by the exogenous DNA, including antigenic proteins, by said cells and host animals.
Inventors
- 👤 Enzo Paoletti
- 👤 Dennis Panicali
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:58
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/63; C12N15/79; C12N15/85; C12N15/86; C07; C07K; C07K14/00; C07K14/005; A; A61; A61K; A61K39/00; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16611; C12N2710/16622; C12N2710/24011; C12N2710/24111; C12N2710/24141; C12N2710/24143; C12N2760/00; C12N2760/00011; C12N2760/16011; C12N2760/16111; C12N2760/16122
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
25 words
A recombinant vaccinia virus synthetically modified by the presence, in a non-essential region of the vaccinia genome, of DNA not naturally occurring in vaccinia virus.
Claim 2
Dependent Claim
25 words
A recombinant vaccinia virus synthetically modified by the presence, in a non-essential region of the vaccinia genome, of DNA not naturally occurring in vaccinia virus.
Claim 3
Dependent Claim
21 words
A vaccinia virus as in claim 1 wherein said DNA is expressed in a host by the production of a protein.
Claim 4
Dependent Claim
13 words
A vaccinia virus as in claim 2 wherein said protein is an antigen.
Claim 5
Dependent Claim
26 words
A vaccinia virus as in claim 2 wherein said DNA is a gene of herpes simplex expressed in a host by the production of thymidine kinase.
Claim 6
Dependent Claim
18 words
A vaccinia virus as in claim 4 wherein said virus is free of vaccinia gene producing thymidine kinase.
Claim 7
Dependent Claim
14 words
A vaccinia virus as in claim 3 wherein said antigen is influenza virus hemmagglutinin.
Claim 8
Dependent Claim
29 words
A vaccinia virus as in claim 1 which is vaccinia virus VP-2, VP-3, VP-4, VP-5, VP-6, VP-7, VP-8, VP-9, VP-10, VP-11, VP-12, VP-13, VP-14, VP-16, VP-17, VP-18, or VP-22.
Claim 9
Dependent Claim
27 words
A recombinant vaccinia virus as in claim 1 wherein said DNA not naturally occurring in vaccinia virus has been introduced into said virus by in vivo recombination.
Claim 10
Dependent Claim
20 words
A modified vaccinia virus as in claim 1 wherein said DNA not naturally occurring in vaccinia virus includes viral DNA.
Claim 11
Dependent Claim
20 words
A modified vaccinia virus as in claim 1 wherein said DNA not naturally occurring in vaccinia virus includes bacterial DNA.
Claim 12
Dependent Claim
20 words
A modified vaccinia virus as in claim 1 wherein said DNA not naturally occurring in vaccinia virus includes synthetic DNA.
Claim 13
Dependent Claim
22 words
A biologically pure culture of a vaccinia virus selected from the group consisting of VTK - 79 and VTK - 79 L.
Claim 14
Dependent Claim
22 words
A biologically pure culture of a vaccinia virus selected from the group consisting of VTK - 79 and VTK - 79 L.
References Cited (Backward Citations)
No citation records indexed.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1989-07-28 | 1990-01-27 | 1990-07-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-07-28 | 1994-01-27 | 1994-07-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-07-28 | 1998-01-27 | 1998-07-29 | $7700.00 | Window Closed / Lapsed |