US4600775A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Isomaleimide and isophthalamide derivatives of chromophors
Assignee: Viomedics Inc
•
Filing: 1984-08-27
•
Granted: 1986-07-15
•
Expires: 2004-08-27
Abstract
Abstract Novel isomaleimido and isophthalimido derivatives of chromophoric compounds are provided which are useful in analytical techniques for the detection and measurement of biological compounds such as bacteria, enzymes, hormones and the like.
Inventors
- 👤 Spyros Theodoropulos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:40
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/02; C07D307/34; C07D237/00; C07D237/26; C07D237/30; C07D237/32; C07D265/00; C07D265/28; C07D265/34; C07D265/38; C07D311/00; C07D311/02; C07D311/78; C07D311/80; C07D311/82; C07D405/00; C07D405/02; C07D405/12; C07D407/00; C07D407/02; C07D407/12
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
108 words
A compound selected from the group consisting of: ##STR7## wherein R represents an organic chromophoric group exhibiting fluorescence, luminescense, chemoluminescence or absorption properties; R 1 , R 2 , R 3 , and R 4 individually represent hydrogen or halogen, or alkyl, aryl, hydroxyl, carboxyl, alkyl or aryl-substituted or unsubstituted amino groups, nitro or sulfonic groups; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, alkyl or aryl-substituted or unsubstituted amino groups, nitro or sulfonic groups with the proviso that R does not contain a group of the formula: ##STR8## wherein R 1 -R 4 ,X and Y are as indicated above.
Claim 2
Dependent Claim
108 words
A compound selected from the group consisting of: ##STR7## wherein R represents an organic chromophoric group exhibiting fluorescence, luminescense, chemoluminescence or absorption properties; R 1 , R 2 , R 3 , and R 4 individually represent hydrogen or halogen, or alkyl, aryl, hydroxyl, carboxyl, alkyl or aryl-substituted or unsubstituted amino groups, nitro or sulfonic groups; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, alkyl or aryl-substituted or unsubstituted amino groups, nitro or sulfonic groups with the proviso that R does not contain a group of the formula: ##STR8## wherein R 1 -R 4 ,X and Y are as indicated above.
Claim 3
Dependent Claim
22 words
The compound of claim 1 which is an N-substituted isomaleimide of the formula: ##STR9## wherein R, X and Y are as indicated.
Claim 4
Dependent Claim
20 words
The compound of claim 1 which is an N-substituted isophthalimide of the formula: ##STR10## wherein R-R 4 are as indicated.
Claim 5
Dependent Claim
12 words
The compound of claim 1 wherein said R group exhibits fluorescence properties.
Claim 6
Dependent Claim
12 words
The compound of claim 1 wherein said R group exhibits luminescence properties.
Claim 7
Dependent Claim
12 words
The compound of claim 1 wherein said R group exhibits chemoluminescence properties.
Claim 8
Dependent Claim
12 words
The compound of claim 1 wherein said R group exhibits absorption properties.
Claim 9
Dependent Claim
40 words
A compound of the formula: ##STR11## wherein R represents a cresyl-violet group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups or nitro or sulfonic groups.
Claim 10
Dependent Claim
40 words
A compound of the formula: ##STR11## wherein R represents a cresyl-violet group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups or nitro or sulfonic groups.
Claim 11
Dependent Claim
40 words
A compound of the formula: ##STR12## wherein R represents an anthraquinone group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 12
Dependent Claim
40 words
A compound of the formula: ##STR12## wherein R represents an anthraquinone group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 13
Dependent Claim
40 words
A compound of the formula: ##STR13## wherein R represents a fluorescein group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 14
Dependent Claim
40 words
A compound of the formula: ##STR13## wherein R represents a fluorescein group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 15
Dependent Claim
40 words
A compound of the formula: ##STR14## wherein R represents a luminol group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 16
Dependent Claim
40 words
A compound of the formula: ##STR14## wherein R represents a luminol group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 17
Dependent Claim
72 words
A compound of the formula: ##STR15## wherein R represents a flourescein group; R 1 , R 2 , R 3 and R 4 individually represent hydrogen or halogen, or alkyl, aryl, hydroxyl, carboxyl, alkyl- or aryl-substituted or unsubstituted amino groups, nitro or sulfonic groups; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 18
Dependent Claim
72 words
A compound of the formula: ##STR15## wherein R represents a flourescein group; R 1 , R 2 , R 3 and R 4 individually represent hydrogen or halogen, or alkyl, aryl, hydroxyl, carboxyl, alkyl- or aryl-substituted or unsubstituted amino groups, nitro or sulfonic groups; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 19
Dependent Claim
109 words
A compound selected from the group consisting of: ##STR16## wherein R represents an organic chromophoric group exhibiting fluorescence, luminescense, chemoluminescence or absorption properties; R 1 , R 2 , R 3 , and R 4 individually represent hydrogen or halogen, or alkyl, aryl. hydroxyl, carboxyl, alkyl or aryl-substituted or unsubstituted amino groups, nitro or sulfonic groups; and X and Y represent hydrogen or halogen, or alkyl, aryl. alkoxy, aryloxy, carboxyl, hydroxyl, alkyl- or aryl-substituted or unsubstituted amino groups, nitro or sulfonic groups with the proviso that R does not contain a group of the formula: ##STR17## wherein R 1 -R 4 , X and Y are as indicated above.
Claim 20
Dependent Claim
109 words
A compound selected from the group consisting of: ##STR16## wherein R represents an organic chromophoric group exhibiting fluorescence, luminescense, chemoluminescence or absorption properties; R 1 , R 2 , R 3 , and R 4 individually represent hydrogen or halogen, or alkyl, aryl. hydroxyl, carboxyl, alkyl or aryl-substituted or unsubstituted amino groups, nitro or sulfonic groups; and X and Y represent hydrogen or halogen, or alkyl, aryl. alkoxy, aryloxy, carboxyl, hydroxyl, alkyl- or aryl-substituted or unsubstituted amino groups, nitro or sulfonic groups with the proviso that R does not contain a group of the formula: ##STR17## wherein R 1 -R 4 , X and Y are as indicated above.
Claim 21
Dependent Claim
22 words
The compound of claim 13 which is a maleamic acid of the formula: ##STR18## wherein R, X and Y are as indicated.
Claim 22
Dependent Claim
20 words
The compound of claim 13 which is a phthalamic acid of the formula: ##STR19## wherein R-R 4 are as indicated.
Claim 23
Dependent Claim
40 words
A compound of the formula: ##STR20## wherein R represents a cresyl-violet group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 24
Dependent Claim
40 words
A compound of the formula: ##STR20## wherein R represents a cresyl-violet group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 25
Dependent Claim
40 words
A compound of the formula: ##STR21## wherein R represents an anthraquinone group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 26
Dependent Claim
40 words
A compound of the formula: ##STR21## wherein R represents an anthraquinone group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 27
Dependent Claim
40 words
A compound of the formula: ##STR22## wherein R represents a fluorescein group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 28
Dependent Claim
40 words
A compound of the formula: ##STR22## wherein R represents a fluorescein group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 29
Dependent Claim
40 words
A compound of the formula: ##STR23## wherein R represents a luminol group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 30
Dependent Claim
40 words
A compound of the formula: ##STR23## wherein R represents a luminol group; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 31
Dependent Claim
72 words
A compound of the formula: ##STR24## wherein R represents a fluorescein group; R 1 , R 2 , R 3 and R 4 individually represent hydrogen or halogen, or alkyl, aryl, hydroxyl, carboxyl, alkyl- or aryl-substituted or unsubstituted amino groups, nitro or sulfonic groups; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
Claim 32
Dependent Claim
72 words
A compound of the formula: ##STR24## wherein R represents a fluorescein group; R 1 , R 2 , R 3 and R 4 individually represent hydrogen or halogen, or alkyl, aryl, hydroxyl, carboxyl, alkyl- or aryl-substituted or unsubstituted amino groups, nitro or sulfonic groups; and X and Y represent hydrogen or halogen, or alkyl, aryl, alkoxy, aryloxy, carboxyl, hydroxyl, or alkyl- or aryl-substituted or unsubstituted amino groups, or nitro or sulfonic groups.
References Cited (Backward Citations)
US2998429A
Cited
US3985773A
Cited
US3990880A
Cited
US4179444A
Cited
US4148625A
Cited
GB2017737A
Cited
US4472190A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-07-14 | 1990-01-13 | 1990-07-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-07-14 | 1994-01-13 | 1994-07-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-07-14 | 1998-01-13 | 1998-07-15 | $7700.00 | Window Closed / Lapsed |