US4600574A
Expired / Lapsed
US
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Method of producing a tissue adhesive
Assignee: Oesterreichisches Institut fuer Haemoderivate
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Filing: 1984-03-21
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Granted: 1986-07-15
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Expires: 2004-03-21
Abstract
Abstract In a method of producing a tissue adhesive based on polysaccharide or on human or animal proteins, a tissue-compatible flat material is impregnated with a solution of fibrinogen and Factor XIII, and lyophilized.
Inventors
- 👤 Adolf Lindner
- 👤 Yendra Linnau
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 08:07
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/106; A61L15/00; A61L15/16; A61L15/22; A61L15/32
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
64 words
A method of producing a tissue adhesive based on polysaccharide or on human or animal proteins, said method comprising the steps of (a) impregnating a tissue-compatible flat material selected from the group consisting of collagen, gelatine and polysaccharide with a solution comprised of fibrinogen and Factor XIII, and (b) lyophilizing said impregnated flat material to obtain a coherent matrix of said tissue-compatible flat material.
Claim 2
Independent Claim
64 words
A method of producing a tissue adhesive based on polysaccharide or on human or animal proteins, said method comprising the steps of (a) impregnating a tissue-compatible flat material selected from the group consisting of collagen, gelatine and polysaccharide with a solution comprised of fibrinogen and Factor XIII, and (b) lyophilizing said impregnated flat material to obtain a coherent matrix of said tissue-compatible flat material.
Claim 3
Dependent Claim
33 words
A method as set forth in claim 1, wherein said tissue-compatible flat material comprises a non-woven fabric or sheet based on a material selected from the group consisting of collagen, gelatine and polysaccharide.
Claim 4
Dependent Claim
32 words
A method as set forth in claim 1, wherein said solution for impregnating said tissue-compatible, flat material further comprises at least one of a plasmin inhibitor, an antibiotic or a cytostatic agent.
Claim 5
Independent Claim
76 words
A method of producing a tissue adhesive based on human or animal proteins, said method comprising the steps of (a) producing a flat material by lyophilizing an aqueous solution of collagen to layers so as to obtain a porous collagen flat material. (b) impregnating said porous collagen flat material with a solution comprised of fibrinogen and Factor XIII, and (c) lyophilizing said impregnated collagen flat material to obtain a coherent matrix of said collagen flat material.
Claim 6
Independent Claim
76 words
A method of producing a tissue adhesive based on human or animal proteins, said method comprising the steps of (a) producing a flat material by lyophilizing an aqueous solution of collagen to layers so as to obtain a porous collagen flat material. (b) impregnating said porous collagen flat material with a solution comprised of fibrinogen and Factor XIII, and (c) lyophilizing said impregnated collagen flat material to obtain a coherent matrix of said collagen flat material.
Claim 7
Independent Claim
41 words
A method of producing a tissue adhesive based on human or animal proteins, said method comprising lyophilizing an aqueous solution of fibrinogen, collagen and Factor XIII in layers so as to form a flat material containing fibrinogen, Factor XIII and collagen.
Claim 8
Independent Claim
41 words
A method of producing a tissue adhesive based on human or animal proteins, said method comprising lyophilizing an aqueous solution of fibrinogen, collagen and Factor XIII in layers so as to form a flat material containing fibrinogen, Factor XIII and collagen.
Claim 9
Dependent Claim
27 words
A method as set forth in claim 5, wherein said aqueous solution further comprises at least one of a plasmin inhibitor, an antibiotic or a cytostatic agent.
Claim 10
Dependent Claim
40 words
A method as set forth in claim 5, further comprising the step of repeating at least once the lyophilizing of aqueous solution of fibrinogen, collagen and factor XIII on the previously formed flat material to form a multi-layered flat material.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-07-14 | 1990-01-13 | 1990-07-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-07-14 | 1994-01-13 | 1994-07-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-07-14 | 1998-01-13 | 1998-07-15 | $7700.00 | Window Closed / Lapsed |