US4599327A
Expired / Lapsed
US
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Dibenzo[bd]pyran derivatives, process for the preparation thereof and pharmaceutical compositions containing same
Assignee: Chinoin Private Co Ltd
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Filing: 1983-12-02
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Granted: 1986-07-08
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Expires: 2003-12-02
Abstract
Abstract 2,6-di-O-methyl-beta-cyclodextrin complexes of compounds of the formula (1a) ##STR1## wherein R 2' stands for C 1 to C 12 alkyl or a group of the formula ##STR2## in which R 11 is C 1 to C 4 alkyl; R 12 is hydrogen or C 1 to C 4 alkyl; n is 0 or 1; p is 1 to 4; r is 1 to 4; and R 3' and R 4' are each C 1 to C 4 alkyl, or pharmaceutically salts thereof are disclosed, having analgesic activity.
Inventors
- 👤 Mihaly Nogradi
- 👤 Dezso Korbonits
- 👤 Agnes Gottsegen
- 👤 Sandor Antus
- 👤 Zsuzsa Furst
- 👤 Jozsef Knoll
- 👤 Jozsef Szejtli
- 👤 Agnes Stadler
- 👤 Gabor Kovacs
- 👤 Katalin Marmarosi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 11:54
CPC Classifications
C; C07; C07D; C07D493/00; C07D493/02; C07D493/10; A; A61; A61P; A61P1/00; A61P1/08; A61P23/00; A61P23/02; A61P25/00; A61P25/02; A61P25/04; C07C; C07C309/00; C07C43/00; C07C43/02; C07C43/03; C07C43/14; C07C43/178; C07C43/1782; C07C43/1785; C07C43/20; C07C43/205; C07C43/2055; C07C43/23; C07C59/00; C07C59/40; C07C59/58; C07C59/64; C07C59/66; C07C59/68; C07D221/00; C07D221/02; C07D221/04; C07D221/06; C07D221/10; C07D221/12; C07D311/00; C07D311/02; C07D311/78; C07D311/80; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0012; C08B37/0015
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
81 words
A 2,6-di-O-methyl-beta-cyclodextrin-complex of a compound of the Formula (Ia) ##STR31## wherein R 2' stands for C 1 -C 12 alkyl or a group of the Formula ##STR32## in which R 11 is C 1 -C 4 alkyl; R 12 is hydrogen or C 1 -C 4 alkyl; n is 0 or 1; p is 1 to 4; r is 1 to 4; and R 3' and R 4' are each C 1 -C 4 alkyl, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
81 words
A 2,6-di-O-methyl-beta-cyclodextrin-complex of a compound of the Formula (Ia) ##STR31## wherein R 2' stands for C 1 -C 12 alkyl or a group of the Formula ##STR32## in which R 11 is C 1 -C 4 alkyl; R 12 is hydrogen or C 1 -C 4 alkyl; n is 0 or 1; p is 1 to 4; r is 1 to 4; and R 3' and R 4' are each C 1 -C 4 alkyl, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
32 words
The 2,6-di-O-methyl-beta-cyclodextrix-complex of the compound of the Formula (I) as defined in claim 1 wherein the compound of the Formula (I) is: 1,9-beta-dihydroxy-6abeta,7,8,9,10,10aalpha-hexahydro-6,6-dimethyl-3-[(2RS)-5-methoxy-2-pentyl]-6H-dibenzo[bd]pyran; 1,9-beta-dihydroxy-6abeta-7,8,9,10,10aalpha-hexahydro-6,6-dimethyl-3[(2RS)-5-ethoxy-2-pentyl]-6H-dibenzo[bd]pyran; or 1,9-beta-dihydroxy-3-pentyl-6a,7,8,9,10,10a-hexahydro-6,6-dimethyl-6H-dibenzo[bd]pyran, or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
31 words
The 2,6-di-O-methyl-beta-cyclodextrin complex of the compound of the Formula (I) as defined in claim 1 wherein R 2' is the group of the Formula ##STR33## or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
14 words
2,6-di-O-methyl-beta-cyclodextrin complex of (±)-1,9β-dihydroxy-6aβ,7,8,9,10,10aα-hexahydro-6.6-dimethyl-3-((2RS)-5-methoxy-2-pentyl)-6H-dibenzo (bd) -pyrane and salts thereof as defined in claim 1.
Claim 6
Dependent Claim
10 words
Complex of 1,9β-Dihydroxy-6aβ,7,8,9,10,10aα-hexahydro-6,6-dimethyl-3-[(2RS)-5-methoxy-2pentyl]-6H-dibenzo[bd]pyrane with 2,6-di-O-methyl-62-cyclodextrin as defined in claim 1.
Claim 7
Dependent Claim
9 words
2,6-di-O-methyl-62-cyclodextrin complex of 1,9β-dihydroxy-3-pentyl-6a,7,8,9,10,10a-hexahydro-6,6-dimethyl-6H-dibenzo[bd]pyrane as defined in claim 1.
Claim 8
Dependent Claim
38 words
An analgesic composition containing as active ingredient a therapeutically effective amount of the 2,6-di-O-methyl-62-cyclodextrin complex of compounds of the formula I or pharmaceutically acceptable salts thereof as defined in claim 1, along with a pharmaceutically acceptable inert carrier.
Claim 9
Dependent Claim
46 words
An analgesic method of treatment which comprises the step of administering to an animal subject in need of said treatment an analgesically effective amount of the 2,6-di-O-methyl-betl-cyclodextrin complex of the compound of the Formula (1a) as defined in claim 1, or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
US3459731A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-07-07 | 1990-01-06 | 1990-07-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-07-07 | 1994-01-06 | 1994-07-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-07-07 | 1998-01-06 | 1998-07-08 | $7700.00 | Window Closed / Lapsed |