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US4597899A
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Process for obtaining a factor XIII preparation, and its use
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1985-05-23
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Granted: 1986-07-01
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Expires: 2005-05-23
Abstract
Abstract A process for obtaining a factor XIII preparation is described, in which the factor XIII is precipitated from a placental extract using an alcohol, and is adsorbed onto an anion exchanger, and the exchanger is washed and the factor XIII is eluted. The factor XIII preparation obtained can be used for the treatment of disturbances of blood coagulation.
Inventors
- 👤 Jurgen Falke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 13:26
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/10; C12N9/1025; C12N9/104; C12N9/1044; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/85; Y10S530/851
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
63 words
A process for obtaining a factor XIII preparation from an aqueous extract of placentae, which comprises precipitating the factor XIII for said extract with a lower alkanol, dissolving the residue in an aqueous solution, bringing the solution into contact with an anion exchanger, removing the liquid, washing the exchanger with a liquid which does not desorb factor XIII, and eluting the factor XIII.
Claim 2
Dependent Claim
63 words
A process for obtaining a factor XIII preparation from an aqueous extract of placentae, which comprises precipitating the factor XIII for said extract with a lower alkanol, dissolving the residue in an aqueous solution, bringing the solution into contact with an anion exchanger, removing the liquid, washing the exchanger with a liquid which does not desorb factor XIII, and eluting the factor XIII.
Claim 3
Dependent Claim
24 words
The process as claimed in claim 1, wherein the alkanol is ethanol, and the concentration of the alcohol in the mixture is 150-300 ml/l.
Claim 4
Dependent Claim
13 words
The process as claimed in claim 1, wherein the anion exchanger is DEAE-cellulose.
Claim 5
Dependent Claim
23 words
The process as claimed in claim 1, wherein the ion exchanger is washed with an aqueous liquid having a conductivity of 1-2 mS.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-30 | 1989-12-30 | 1990-07-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-30 | 1993-12-30 | 1994-07-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-30 | 1997-12-30 | 1998-07-01 | $7700.00 | Window Closed / Lapsed |