US4596825A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of treating liver disturbances resulting from alcohol consumption and a composition therefor
Assignee: Ajinomoto Co Inc
•
Filing: 1985-08-05
•
Granted: 1986-06-24
•
Expires: 2005-08-05
Abstract
Abstract A pharmaceutical composition for preventing or alleviating the effects of acute alcoholism, in particular liver disturbances in mammals, which comprises a mixture of alanine or a pharmaceutically acceptable salt or derivative thereof capable of effectively acting as alanine in vivo or a mixture thereof, and ornithine or a pharmaceutically acceptable salt or derivative thereof capable of effectively acting as ornithine in vivo or a mixture thereof in a ratio such that the amount of ornithine present in said mixture is at least about 1/1000 the amount of alanine present, both of said ornithine and alanine being present in an amount effective to prevent or alleviate said effects.
Inventors
- 👤 Tomio Suda
- 👤 Masaharu Horiguchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:46
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195; A61P; A61P1/00; A61P1/16; A61P39/00; A61P39/02
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
108 words
A method of preventing or alleviating alcoholic liver disturbances in mammals which comprises administering to said mammal a pharmaceutical composition consisting essentially of alanine or a pharmaceutically acceptable salt or other derivative thereof capable of effectively acting as alanine in vivo or a mixture thereof, and ornithine or a pharmaceutically acceptable salt or other derivative thereof capable of effectively acting as ornithine in vivo or a mixture thereof in a ratio such that the molar ratio of ornithine to alanine in said mixture is about 1:0.001 to 10, both of said ornithine and alanine being present in an amount effective to prevent or alleviate said alcoholic liver disturbance.
Claim 2
Independent Claim
108 words
A method of preventing or alleviating alcoholic liver disturbances in mammals which comprises administering to said mammal a pharmaceutical composition consisting essentially of alanine or a pharmaceutically acceptable salt or other derivative thereof capable of effectively acting as alanine in vivo or a mixture thereof, and ornithine or a pharmaceutically acceptable salt or other derivative thereof capable of effectively acting as ornithine in vivo or a mixture thereof in a ratio such that the molar ratio of ornithine to alanine in said mixture is about 1:0.001 to 10, both of said ornithine and alanine being present in an amount effective to prevent or alleviate said alcoholic liver disturbance.
Claim 3
Dependent Claim
21 words
The method of claim 1, wherein said alcoholic liver disturbances comprise loss of consciousness and degeneration and swelling of liver cells.
Claim 4
Dependent Claim
14 words
The method of claim 1, wherein said composition is administered orally, parenterally or intraperitoneally.
Claim 5
Dependent Claim
41 words
The method of claim 3, wherein said mixture is administered in an amount such that alanine and ornithine are provided to said mammal in the amount of about 1-5 mmol/kg of body weight and about 0.001-50 mmol/kg of body weight, respectively.
Claim 6
Dependent Claim
41 words
The method of claim 4, wherein said mixture is administered in an amount such that alanine and ornithine are provided to said mammal in the amount of about 2.5 mmol/kg of body weight and about 0.625 mmol/kg of body weight, respectively.
Claim 7
Dependent Claim
11 words
The method of claim 1, wherein said mammal is a human.
Claim 8
Dependent Claim
104 words
A pharmaceutical composition for preventing or alleviating alcoholic liver disturbances in mammals, which consists essentially of a mixture of alanine or a pharmaceutically acceptable salt or other derivative thereof capable of effectively acting as alanine in vivo, or a mixture thereof, and ornithine or a pharmaceutically acceptable salt or other derivative thereof capable of effectively acting as ornithine in vivo, or a mixture thereof in a ratio such that the molar ratio of ornithine to alanine in said mixture is about 1:0.001 to 10, both of said ornithine and alanine being present in an amount effective to prevent or alleviate said alcoholic liver disturbances.
Claim 9
Dependent Claim
104 words
A pharmaceutical composition for preventing or alleviating alcoholic liver disturbances in mammals, which consists essentially of a mixture of alanine or a pharmaceutically acceptable salt or other derivative thereof capable of effectively acting as alanine in vivo, or a mixture thereof, and ornithine or a pharmaceutically acceptable salt or other derivative thereof capable of effectively acting as ornithine in vivo, or a mixture thereof in a ratio such that the molar ratio of ornithine to alanine in said mixture is about 1:0.001 to 10, both of said ornithine and alanine being present in an amount effective to prevent or alleviate said alcoholic liver disturbances.
Claim 10
Dependent Claim
21 words
The pharmaceutical composition of claim 1, wherein the ratio of ornithine to alanine is in the range of 0.05-0.5 to 1.
Claim 11
Dependent Claim
21 words
The pharmaceutical composition of claim 1, wherein the ratio of ornithine to alanine is in the range of 0.25 to 1.
Claim 12
Dependent Claim
27 words
The pharmaceutical composition of claim 1, wherein said mixture comprises L-alanine and L-ornithine, or DL-alanine and L-ornithine, or L-alanine and L-ornithine hydrochloride and DL-alanine and L-ornithing hydrochloride.
Claim 13
Dependent Claim
24 words
The pharmaceutical composition of claim 1, wherein said alanine and ornithine mixture comprises about 0.01 to 100% by weight of the total composition weight.
Claim 14
Dependent Claim
33 words
The pharmaceutical composition of claim 1, which further comprises water, gelatin, sugars, starch, fatty acids and salts thereof, alcohols, oils, fats, talc or physiological saline solution or a mixture of two or more.
Claim 15
Dependent Claim
8 words
A foodstuff comprising the mixture of claim 1.
Claim 16
Dependent Claim
13 words
The foodstuff according to claim 3, comprising 0.01-10% by weight of said mixture.
References Cited (Backward Citations)
US3950529A
Cited
US4279917A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-23 | 1989-12-23 | 1990-06-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-23 | 1993-12-23 | 1994-06-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-23 | 1997-12-23 | 1998-06-24 | $7700.00 | Window Closed / Lapsed |