US4596805A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted dioxopyridopyrimidines
Assignee: Ortho Pharmaceutical Corp
•
Filing: 1984-06-13
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Granted: 1986-06-24
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Expires: 2004-06-13
Abstract
Abstract Substituted dioxopyridopyrimidines are provided which are useful as calcium antagonists and anti-hypertensive agents.
Inventors
- 👤 Jack B. Jiang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 13:57
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
67 words
A compound having the formula ##STR7## and the pharmaceutically acceptable acid addition salts thereof, wherein: R is hydrogen or loweralkyl; Ar is aryl, furanyl, or cyclohexyl; R' is loweralkyl, loweralkyl substituted with one halo or trifluoromethyl group, or (arylloweralkyl)(loweralkyl)aminoloweralkyl; and X is 0 or S; said aryl being phenyl or phenyl substituted with one or two substituents independently selected from halo, nitro, cyano, loweralkyl, loweralkyloxy, and trifluoromethyl.
Claim 2
Dependent Claim
67 words
A compound having the formula ##STR7## and the pharmaceutically acceptable acid addition salts thereof, wherein: R is hydrogen or loweralkyl; Ar is aryl, furanyl, or cyclohexyl; R' is loweralkyl, loweralkyl substituted with one halo or trifluoromethyl group, or (arylloweralkyl)(loweralkyl)aminoloweralkyl; and X is 0 or S; said aryl being phenyl or phenyl substituted with one or two substituents independently selected from halo, nitro, cyano, loweralkyl, loweralkyloxy, and trifluoromethyl.
Claim 3
Dependent Claim
25 words
The compound of claim 1 wherein R is lowerlkyl, X is O, Ar is aryl, and R' is loweralkyl, halo-substituted loweralkyl, or (arylloweralkyl) (loweralkyl) aminoloweralkyl.
Claim 4
Dependent Claim
23 words
The compound of claim 1 wherein R is methyl, X is O, Ar is aryl, and R' is halo-substituted loweralkyl or (arylloweralkyl)(loweralkyl) aminoloweralkyl.
Claim 5
Dependent Claim
39 words
The compound of claim 1 wherein R is methyl, X is O, Ar is 3-halophenyl or 3-nitrophenyl, and R' is CH 2 CH 2 Br or CH 2 CH 2 N(CH 3 )CH 2 --C 6 H 5 .
Claim 6
Dependent Claim
37 words
The compound of claim 1 wherein R is methyl, X is O, Ar is 3-chlorophenyl, and R' is CH 2 CH 2 Br or CH 2 CH 2 N(CH 3 )CH 2 --C 6 H 5 .
Claim 7
Dependent Claim
10 words
The compound of claim 1 which is 2-(N-benzyl-N-methylamino)ethyl 5-(3-chlorophenyl)-5,8-dihydro-1,3,7-trimethyl-2,4 dioxopyrido[2,3-d]pyrimidine-6-carboxylate.
Claim 8
Dependent Claim
21 words
A pharmaceutical composition comprising an effective anti-hypertensive amount of a compound of claim 1 in admixture with a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
23 words
A pharmaceutical composition comprising an effective calcium channel inhibiting amount of a compound of claim 1 in admixture with a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-23 | 1989-12-23 | 1990-06-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-23 | 1993-12-23 | 1994-06-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-23 | 1997-12-23 | 1998-06-24 | $7700.00 | Window Closed / Lapsed |