US4596705A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oral mopidamol preparation
Assignee: Boehringer Ingelheim Pharma GmbH and Co KG
•
Filing: 1983-10-07
•
Granted: 1986-06-24
•
Expires: 2003-10-07
Abstract
Abstract This invention relates to vehicles for the administration of mopidamol. More specifically, this invention relates to a method of treating cardiovascular disorders, malignancy, or thrombosis in a host in need of such treatment which comprises administering to said host a cardiovascularly, antimetastic, or antithrombotic effective amount of a composition comprised of (i) mopidamol or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least about 1 acid equivalent to 1 mol of mopidamol.
Inventors
- 👤 Gottfried Schepky
- 👤 Rolf Brickl
- 👤 Peter Gruber
- 👤 Jochen Schmid
- 👤 Ursula Springmeier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 14:50
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2013; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61K9/48; A61K9/4841; A61K9/50; A61K9/5073; A61K9/5078; A61P; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
53 words
A composition which comprises (i) mopidamol or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least 1 acid equivalent to 1 mol of mopidamol.
Claim 2
Dependent Claim
53 words
A composition which comprises (i) mopidamol or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least 1 acid equivalent to 1 mol of mopidamol.
Claim 3
Dependent Claim
38 words
The composition of claim 1, wherein the total amount of acid from acid addition salt present and acid or acid substance is in a ratio of from about 1 to 8 acid equivalents to 1 mol of mopidamol.
Claim 4
Dependent Claim
66 words
The composition of claim 1, wherein the pharmacologically acceptable acid or acid substance is selected from the group consisting of tartaric acid, citric acid, fumaric acid, succinic acid, malic acid, ascorbic acid, adipic acid, sodium or potassium salts of said acids, sodium or potassium hydrogen sulfate, betaine hydrochloride, anhydrides of succinic or glutaric acid which hydrolyse in water to form acids, D-glucuronic acid-γ-lactone, and mixtures thereof.
Claim 5
Dependent Claim
16 words
The method of claim 1, wherein the pharmacologically acceptable acid or acid substance is fumaric acid.
Claim 6
Dependent Claim
17 words
The composition of claim 1, wherein the composition is in the form of tablets or tablet cores.
Claim 7
Dependent Claim
13 words
The composition of claim 1, wherein the composition also comprises conventional pharmacological additives.
Claim 8
Dependent Claim
24 words
The composition of claim 6, wherein the additives are selected from the group consisting of water-soluble binders, mucilaginous excipients, water-dissolution aids, and mixtures thereof.
Claim 9
Dependent Claim
26 words
The composition of claim 7, wherein the additives are selected from the group consisting of methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropyl methylcellulose, polyacrylic acids, fats, and mixtures thereof.
Claim 10
Dependent Claim
46 words
The composition of claim 1 which comprises coated tablet cores prepared by compressing granules consisting of mopidamol or an acid addition salt thereof, acid or acid substance, lubricant, and other conventional additives to form tablet cores and then coating said tablet cores with a flavor-masking coating.
Claim 11
Dependent Claim
62 words
The composition of claim 1 which comprises coated cores prepared by (a) moist or dry granulation of (i) mopidamol or an acid addition salt thereof and (ii) acid or acid substance to form a granulate; (b) addition of further, conventional excipients to said granulate; (c) compression of said granulate to form cores; and (d) coating of said cores with a flavor-masking coating.
Claim 12
Dependent Claim
63 words
The composition of claim 1 which comprises coated cores prepared by (a) moist or dry granulation of (i) mopidamol or an acid addition salt thereof and (ii) conventional excipients to form a granulate; (b) addition of acid or acid substance and lubricant to said granulate; (c) compression of said granulate to form cores; and (d) coating of said cores with a flavor-masking coating.
Claim 13
Dependent Claim
36 words
A method for the treatment of cardiovascular disorders or thrombosis in a host in need of such treatment which comprises administering to said host a cardiovascularly or antithrombotically effective amount of a composition of claim 1.
References Cited (Backward Citations)
US4361546A
Cited
US4459279A
Cited
US4367217A
Cited
US4427648A
Cited
US4438091A
Cited
DE3237575A1
Cited
GB2128088A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-23 | 1989-12-23 | 1990-06-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-23 | 1993-12-23 | 1994-06-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-23 | 1997-12-23 | 1998-06-24 | $7700.00 | Window Closed / Lapsed |