US4594425A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Heterocyclic compounds as antiallergic agents
Assignee: Wyeth LLC
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Filing: 1984-02-09
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Granted: 1986-06-10
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Expires: 2004-02-09
Abstract
Abstract There are disclosed compounds of the formula <IMAGE> wherein <IMAGE> <IMAGE> <IMAGE> +TR <IMAGE> <IMAGE> n is 0-6; A is O or S; B is OR2, SR2 or N(R2)2; R1 is hydrogen, loweralkyl, loweralkoxy or halo; R2 is hydrogen or loweralkyl; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like.
Inventors
- 👤 John H. Musser
- 👤 Dennis M. Kubrak
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 08:50
CPC Classifications
C; C07; C07D; C07D277/00; C07D277/60; C07D277/62; C07D277/68; C07D277/64; C07D307/00; C07D307/77; C07D307/78; C07D307/79; C07D307/80
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
47 words
A compound having the formula ##STR11## n is 0-6; A is O or S; B is OR 2 , SR 2 or N(R 2 ) 2 ; R 1 is hydrogen, loweralkyl, loweralkoxy or halo; R 2 is hydrogen or loweralkyl; and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
47 words
A compound having the formula ##STR11## n is 0-6; A is O or S; B is OR 2 , SR 2 or N(R 2 ) 2 ; R 1 is hydrogen, loweralkyl, loweralkoxy or halo; R 2 is hydrogen or loweralkyl; and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
11 words
The compound of claim 1, which is 4-[[3-[(2-benzthiazolyl)methoxy]phenyl]amino]-4-oxobutanoic acid, methyl ester.
Claim 4
Dependent Claim
11 words
The compound of claim 1, which is 4-[[3-[(2-benzoxazolyl)methoxy]phenyl]amino]-4-oxobutanoic acid, methyl ester.
Claim 5
Dependent Claim
11 words
The compound of claim 1 which is 4-[[3-[(1-methyl-2-benzimidazolyl)methoxy]phenyl]amino-4-oxobutanoic acid, methyl ester.
Claim 6
Dependent Claim
11 words
The compound of claim 1, which is 3-[[3-[(2-benzthiazolyl)methoxy]phenyl]amino]-3-oxopropanoic acid, methyl ester.
Claim 7
Dependent Claim
11 words
The compound of claim 1, which is 3-[[3-[(1-methyl-2-benzimidazolyl)methoxy]phenyl]amino]-3-oxopropanoic acid, methyl ester.
Claim 8
Dependent Claim
11 words
The compound of claim 1, which is 4-[[3-[(2-benzthiazolyl)oxy]phenyl]amino]-4-oxobutanoic acid, methyl ester.
Claim 9
Dependent Claim
11 words
The compound of claim 1, which is 4-[N-methyl-[3-[(2-benzthiazolyl)methoxy]phenyl]amino]-4-oxobutanoic acid, methyl ester.
Claim 10
Dependent Claim
11 words
The compound of claim 1, which is 4-[[3-[(2-benzthiazolyl)methoxy]phenyl]hydroxylamino]-4-oxobutanoic acid, methyl ester.
References Cited (Backward Citations)
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Cited
US3594373A
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US3740413A
Cited
US4130413A
Cited
US4314065A
Cited
US4296129A
Cited
US4448965A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-09 | 1989-12-09 | 1990-06-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-09 | 1993-12-09 | 1994-06-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-09 | 1997-12-09 | 1998-06-10 | $7700.00 | Window Closed / Lapsed |