US4593095A
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US
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Xanthine derivatives
Assignee: Johns Hopkins University
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Filing: 1983-02-18
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Granted: 1986-06-03
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Expires: 2003-02-18
Abstract
Abstract Novel 8-phenylxanthines which are potent adenosine receptor antagonists.
Inventors
- 👤 Solomon H. Snyder
- 👤 John W. Daly
- 👤 Robert F. Bruns
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 15:41
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/02; C07D473/04; C07D473/06; C07D473/08; A; A61; A61P; A61P11/00; A61P11/08; A61P25/00; A61P25/26; A61P43/00; A61P7/00; A61P7/10; A61P9/00; A61P9/04
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
137 words
A compound, which in its free base form, has the formula ##STR4## wherein X is NH; R 1 is allyl, alkyl of 2-6 carbons, or cycloalkyl of 3 to 6 carbons, the lower alkyl or cycloalkyl being optionally substituted with hydroxy, lower alkoxy or cyano; R 2 is hydrogen, allyl, lower alkyl or cycloalkyl, the lower alkyl or cycloalkyl being optionally substituted as hereinafter described, R 3 is NH 2 or OH; R 4 is halogen, halo-lower alkyl, phenyl, amino, carboxy, lower alkyl, cycloalkyl, lower alkoxy, cycloalkoxy, lower alkoxy amino, lower alkyl amino or cycloalkylamino, the lower alkoxy, lower alkyl or cycloalkyl in each instance being optionally substituted with hydroxy, amino, methylamino, dimethylamino or carboxy; and R 5 , which may be the same or different, are hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, nitro or amino.
Claim 2
Dependent Claim
137 words
A compound, which in its free base form, has the formula ##STR4## wherein X is NH; R 1 is allyl, alkyl of 2-6 carbons, or cycloalkyl of 3 to 6 carbons, the lower alkyl or cycloalkyl being optionally substituted with hydroxy, lower alkoxy or cyano; R 2 is hydrogen, allyl, lower alkyl or cycloalkyl, the lower alkyl or cycloalkyl being optionally substituted as hereinafter described, R 3 is NH 2 or OH; R 4 is halogen, halo-lower alkyl, phenyl, amino, carboxy, lower alkyl, cycloalkyl, lower alkoxy, cycloalkoxy, lower alkoxy amino, lower alkyl amino or cycloalkylamino, the lower alkoxy, lower alkyl or cycloalkyl in each instance being optionally substituted with hydroxy, amino, methylamino, dimethylamino or carboxy; and R 5 , which may be the same or different, are hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, nitro or amino.
Claim 3
Dependent Claim
35 words
A compound according to claim 1 wherein X is NH, R 1 and R 2 are alkyl of 3 or more carbons, R 3 is amino, R 4 is halogen and R 5 is hydrogen.
Claim 4
Dependent Claim
19 words
A compound according to claim 1 wherein R 1 and R 2 are alkyl of at least 3 carbons.
Claim 5
Dependent Claim
15 words
A compound according to claim 3 wherein R 1 and R 2 are both propyl.
Claim 6
Dependent Claim
9 words
A compound according to claim 1 which is 1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-02 | 1989-12-02 | 1990-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-02 | 1993-12-02 | 1994-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-02 | 1997-12-02 | 1998-06-03 | $7700.00 | Window Closed / Lapsed |