US4593048A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Base composition for external preparations, pharmaceutical composition for external use and method of promoting percutaneous drug absorption
Assignee: Nitto Denko Corp
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Filing: 1982-09-24
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Granted: 1986-06-03
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Expires: 2002-09-24
Abstract
Abstract A composition capable of promoting the skin permeation or percutaneous absorption of a drug, which comprises a lower alcohol and at least one member of the group consisting of a saturated aliphatic hydrocarbon containing 5 to 20 carbon atoms, which may optionally be halogen-substituted, a monohydric alcohol ester of an aliphatic carboxylic acid, which contains 13 to 24 carbon atoms, and an ether containing 8 to 16 carbon atoms with one ether bondage in the molecule; and an external preparation containing the above composition as a base.
Inventors
- 👤 Susumu Sato
- 👤 Umiko Takakura
- 👤 Mitsuru Tamada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 00:59
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/14
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
147 words
A composition which comprises a lower alcohol containing 1 to 4 carbon atoms and at least one adjuvant selected from the group consisting of (1) a saturated, acyclic, aliphatic hydrocarbon containing 6 to 16 carbon atoms, (2) a saturated cyclic, aliphatic hydrocarbon containing 6 to 12 carbon atoms, (3) a saturated, acyclic, halogenated, aliphatic hydrocarbon containing 6 to 16 carbon atoms, (4) a saturated, cyclic, halogenated, aliphatic hydrocarbon containing 6 to 12 carbon atoms, (5) an aliphatic carboxylic acid monohydric alcohol ester containing 19 to 24 carbon atoms in total wherein the carboxylic acid moiety is a fatty acid moiety containing 18 carbon atoms and the alcohol moiety contains 1 to 6 carbon atoms, and (6an acyclic ether containing 8 to 16 carbon atoms with one ether bonding per molecule, the amount of the adjuvant being 1 to 50 percent by weight based on the lower alcohol.
Claim 2
Dependent Claim
147 words
A composition which comprises a lower alcohol containing 1 to 4 carbon atoms and at least one adjuvant selected from the group consisting of (1) a saturated, acyclic, aliphatic hydrocarbon containing 6 to 16 carbon atoms, (2) a saturated cyclic, aliphatic hydrocarbon containing 6 to 12 carbon atoms, (3) a saturated, acyclic, halogenated, aliphatic hydrocarbon containing 6 to 16 carbon atoms, (4) a saturated, cyclic, halogenated, aliphatic hydrocarbon containing 6 to 12 carbon atoms, (5) an aliphatic carboxylic acid monohydric alcohol ester containing 19 to 24 carbon atoms in total wherein the carboxylic acid moiety is a fatty acid moiety containing 18 carbon atoms and the alcohol moiety contains 1 to 6 carbon atoms, and (6an acyclic ether containing 8 to 16 carbon atoms with one ether bonding per molecule, the amount of the adjuvant being 1 to 50 percent by weight based on the lower alcohol.
Claim 3
Dependent Claim
12 words
A composition according to claim 1, wherein said adjuvant comprises said (1).
Claim 4
Dependent Claim
12 words
A composition according to claim 1, wherein said adjuvant comprises said (2).
Claim 5
Dependent Claim
12 words
A composition according to claim 1, wherein said adjuvant comprises said (3).
Claim 6
Dependent Claim
12 words
A composition according to claim 1, wherein said adjuvant comprises said (4).
Claim 7
Dependent Claim
12 words
A composition according to claim 1, wherein said adjuvant comprises said (5).
Claim 8
Dependent Claim
12 words
A composition according to claim 1, wherein said adjuvant comprises said (6).
References Cited (Backward Citations)
US4309414A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-02 | 1989-12-02 | 1990-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-02 | 1993-12-02 | 1994-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-02 | 1997-12-02 | 1998-06-03 | $7700.00 | Window Closed / Lapsed |