US4593034A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides
Assignee: AH Robins Co Inc
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Filing: 1984-04-06
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Granted: 1986-06-03
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Expires: 2004-04-06
Abstract
Abstract 2-Alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides having the formula ##STR1## wherein X is oxygen or sulfur; R 1 is loweralkyl; and R 2 is selected from the group consisting of hydrogen, halo, 4,5-benzo, alkoxy or Am and n is 1 or 2, and the pharmaceutically acceptable acid addition salts thereof having gastrokinetic and anti-emetic activity are disclosed.
Inventors
- 👤 Harry R. Munson, Jr.
- 👤 Robert F. Boswell, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 09:56
CPC Classifications
C; C07; C07D; C07D453/00; C07D453/02; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61P; A61P1/00; A61P1/08
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
101 words
A method for treating warm blooded animals for emesis caused by administration of platinum drugs during cancer treatment which comprises internally administering thereto an emesis inhibiting effective amount of a compound selected from the group consisting of 2-alkoxy-N-(1-azabicyclo[2.2.2]-oct-3-yl)benzamides and thiobenzamides of the formula: ##STR7## wherein; X is oxygen or sulphur R 1 is loweralkyl containing up to eight carbons R 2 is selected from the group consisting of hydrogen, halo, 4,5-benzo, alkoxy containing up to eight carbons or Am wherein Am is selected from amino, methylamino or dimethylamino, n is 1 or 2, and the pharmaceutically acceptable acid addition salts thereof.
Claim 2
Independent Claim
101 words
A method for treating warm blooded animals for emesis caused by administration of platinum drugs during cancer treatment which comprises internally administering thereto an emesis inhibiting effective amount of a compound selected from the group consisting of 2-alkoxy-N-(1-azabicyclo[2.2.2]-oct-3-yl)benzamides and thiobenzamides of the formula: ##STR7## wherein; X is oxygen or sulphur R 1 is loweralkyl containing up to eight carbons R 2 is selected from the group consisting of hydrogen, halo, 4,5-benzo, alkoxy containing up to eight carbons or Am wherein Am is selected from amino, methylamino or dimethylamino, n is 1 or 2, and the pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein the compound is 4-amino-N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxybenzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
18 words
The method of claim 1 wherein the compound is N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide or a pharmaceutically acceptable acid addition salt thereof.
References Cited (Backward Citations)
US3579523A
Cited
GB1293446A
Cited
US3857848A
Cited
US4093734A
Cited
FR2531083A1
Cited
GB2125398A
Cited
EP0099789A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-02 | 1989-12-02 | 1990-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-02 | 1993-12-02 | 1994-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-02 | 1997-12-02 | 1998-06-03 | $7700.00 | Window Closed / Lapsed |