US4593019A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N6 -tricyclic adenosines
Assignee: Warner Lambert Co LLC
•
Filing: 1984-10-26
•
Granted: 1986-06-03
•
Expires: 2004-10-26
Abstract
Abstract N 6 -Tricyclic adenosines and pharmaceutically acceptable acid addition salts having highly desirable central nervous system and cardiovascular properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
Inventors
- 👤 James A. Bristol
- 👤 Walter Moos
- 👤 Bharat K. Trivedi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 06:26
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/16; A; A61; A61P; A61P25/00; A61P25/04; A61P25/20; A61P9/00; A61P9/12
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
198 words
A compound of the formula: ##STR6## wherein R 6a is hydrogen or lower alkyl; R 6b is hydrogen, hydroxy, lower alkyl, lower alkanoyloxy- or benzoyloxy; R 6c and 6d are each independently hydrogen or one or more substituents selected from halogen, hydroxy, lower alkoxy, lower alkanoyloxy, benzoyloxy, lower S(O)n-alkyl in which n is 0, 1, or 2, sulfonamide, trifluoromethyl, lower alkyl, lower mono- or dialkylamino, nitro or sulfhydryl; X is a valence bond or a straight or branched alkylene of 1 to 8 carbon atoms; Y is a valence bond, oxygen, sulfur, NR in which R is hydrogen, lower alkyl, lower alkanoyl or benzoyl, --(CH 2 )n-- in which n is 1 or 2 or --CH═CH--; R 2 is hydrogen, halogen, NR i R ii , or i or SR i in which R i and R ii are each independently hydrogen, lower alkyl or phenyl, lower alkyl; R 2' , R 3' , and R 5' are each independently hydrogen, lower alkanoyl, benzoyl, benzoyl substituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl, or R 2' and R 3' may be bonded together to form a lower alkylidene group, on a pharmaceutically acceptable acid form salt thereof.
Claim 2
Dependent Claim
198 words
A compound of the formula: ##STR6## wherein R 6a is hydrogen or lower alkyl; R 6b is hydrogen, hydroxy, lower alkyl, lower alkanoyloxy- or benzoyloxy; R 6c and 6d are each independently hydrogen or one or more substituents selected from halogen, hydroxy, lower alkoxy, lower alkanoyloxy, benzoyloxy, lower S(O)n-alkyl in which n is 0, 1, or 2, sulfonamide, trifluoromethyl, lower alkyl, lower mono- or dialkylamino, nitro or sulfhydryl; X is a valence bond or a straight or branched alkylene of 1 to 8 carbon atoms; Y is a valence bond, oxygen, sulfur, NR in which R is hydrogen, lower alkyl, lower alkanoyl or benzoyl, --(CH 2 )n-- in which n is 1 or 2 or --CH═CH--; R 2 is hydrogen, halogen, NR i R ii , or i or SR i in which R i and R ii are each independently hydrogen, lower alkyl or phenyl, lower alkyl; R 2' , R 3' , and R 5' are each independently hydrogen, lower alkanoyl, benzoyl, benzoyl substituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl, or R 2' and R 3' may be bonded together to form a lower alkylidene group, on a pharmaceutically acceptable acid form salt thereof.
Claim 3
Dependent Claim
17 words
A compound as claimed in claim 1, wherein R 6 a and R 6 b are hydrogen.
Claim 4
Dependent Claim
26 words
A compound as claimed in claim 1, wherein R 6 a , R 6 b , R 6 c , and R 6 d are hydrogen.
Claim 5
Dependent Claim
24 words
A compound as claimed in claim 3, where X is a valence bond, methylene or ethylene and Y is a valence bond or oxygen.
Claim 6
Dependent Claim
12 words
A compond as claimed in claim 4, wherein R 2 is hydrogen.
Claim 7
Dependent Claim
19 words
A compound as claimed in claim 5, wherein R 2' , R 3' , and R 5' are hydrogen.
Claim 8
Dependent Claim
12 words
A compound as claimed in claim 6, and being N 6 -fluorenyladenosine.
Claim 9
Dependent Claim
12 words
A copound as claimed in claim 6, and being N 6 -fluorenylmethyladenosine.
Claim 10
Dependent Claim
12 words
A compound as claimed in claim 6, and being N 6 -fluorenylethyladenosine.
Claim 11
Dependent Claim
12 words
A compound as claimed in claim 6, and being N 6 -(xanthene-9-methylamino)adenosine.
Claim 12
Dependent Claim
25 words
A pharmaceutical composition for treating psychosis comprising an antipsychotic effective amount of a compound as claimed in claim 1 together with a pharmaceutically acceptable carrier.
Claim 13
Dependent Claim
31 words
A method of treating psychosis in a mammal suffering therefrom comprising administering to such mammal an antipsychotic effective amount of a compound as claimed in claim 1 in unit dosage form.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-02 | 1989-12-02 | 1990-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-02 | 1993-12-02 | 1994-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-02 | 1997-12-02 | 1998-06-03 | $7700.00 | Window Closed / Lapsed |