US4591638A
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Dextran or crosslinked dextran having quaternary amino groups
Assignee: Cytiva Sweden AB
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Filing: 1982-05-11
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Granted: 1986-05-27
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Expires: 2002-05-11
Abstract
Abstract The invention relates to a new polymer containing quarternary amino group based on dextran or cross-linked dextran. The quarternary amino groups are of the formula <IMAGE> where R1, R2 and R3, which may be identical or different, are lower alkyl groups of 1-5 carbon atoms or lower hydroxyalkyl groups of 2-5 carbon atoms and 1-2 hydroxy groups. At most one atom other than carbon and hydrogen is bound to the same carbon atom in the hydroxy alkyl group.
Inventors
- 👤 Leif G. Ahrgren
- 👤 Anthony N. de Belder
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 07:27
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0021; A; A61; A61P; A61P3/00; A61P3/06
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
76 words
A polymer consisting of dextran or crosslinked dextran containing quarternary amino groups wherein the quarternary amino groups have the formula ##STR6## where R 1 , R 2 and R 3 , which may be identical or different, are lower alkyl groups of 1-5 carbon atoms, or lower hydroxyalkyl groups having 2-5 carbon atoms and 1-2 hydroxy groups with at most one hydroxy group being bound to one and the same carbon atom in the hydroxyalkyl group.
Claim 2
Dependent Claim
76 words
A polymer consisting of dextran or crosslinked dextran containing quarternary amino groups wherein the quarternary amino groups have the formula ##STR6## where R 1 , R 2 and R 3 , which may be identical or different, are lower alkyl groups of 1-5 carbon atoms, or lower hydroxyalkyl groups having 2-5 carbon atoms and 1-2 hydroxy groups with at most one hydroxy group being bound to one and the same carbon atom in the hydroxyalkyl group.
Claim 3
Dependent Claim
26 words
A polymer according to claim 1 wherein each of R 1 , R 2 and R 3 is a lower alkyl group of 1-2 carbon atoms.
Claim 4
Dependent Claim
24 words
A polymer according to claim 1 or 2 wherein the dextran is crosslinked to a three-dimensional network and is insoluble but swellable in water.
Claim 5
Dependent Claim
17 words
A polymer according to claim 1 wherein R 1 , R 2 and R 3 are methyl.
Claim 6
Dependent Claim
33 words
A polymer according to claim 1 wherein at least one of the groups R 1 , R 2 and R 3 is selected from the group of 2-hydroxyethyl, 2-hydroxypropyl and 2,3 dihydroxy propyl.
Claim 7
Dependent Claim
73 words
A polymer according to claim 1 wherein the dextran is cross-linked by bridges, which are bound to the dextran chains by ether bonds, said bridges comprising straight or branched, aliphatic, saturated hydrocarbon chains being substituted with one or more hydroxyl groups, and containing 3-20 carbon atoms, and being broken by one or more oxygen atoms, no more than one oxygen atom being bound to one and the same carbon atom in the bridge.
Claim 8
Dependent Claim
37 words
A polymer according to any one of claims 1, 2, 4, 5 or 6 wherein the mean degree of substitution of the quaternary amino groups in the dextran or cross-linked dextran is within the range of 0.05-3.
Claim 9
Dependent Claim
31 words
A polymer according to claim 7 wherein the dextran is crosslinked to a degree that it is insoluble in water and each gram can absorb 2 to 20 grams of water.
Claim 10
Dependent Claim
29 words
A polymer according to claim 3 wherein the ion exchange capacity is in the range of 0.1-6 meq/g calculated per gram of dry product with chloride as counter ion.
Claim 11
Dependent Claim
82 words
An insoluble ion-exchanger, substantially free from leakage of toxic compounds, consisting of crosslinked dextran containing quarternary amino groups wherein the quarternary amino groups have the formula ##STR7## wherein R 1 , R 2 and R 3 , which may be identical or different, are lower alkyl groups of 1-5 carbon atoms, or lower hydroxyalkyl groups having 2-5 carbon atoms and 1-2 hydroxy groups with at most one hydroxy group being bound to one and the same carbon atom in the hydroxyalkyl group.
Claim 12
Dependent Claim
82 words
An insoluble ion-exchanger, substantially free from leakage of toxic compounds, consisting of crosslinked dextran containing quarternary amino groups wherein the quarternary amino groups have the formula ##STR7## wherein R 1 , R 2 and R 3 , which may be identical or different, are lower alkyl groups of 1-5 carbon atoms, or lower hydroxyalkyl groups having 2-5 carbon atoms and 1-2 hydroxy groups with at most one hydroxy group being bound to one and the same carbon atom in the hydroxyalkyl group.
Claim 13
Dependent Claim
26 words
An ion-exchanger according to claim 10 wherein each of R 1 , R 2 and R 3 is a lower alkyl group of 1-2 carbon atoms.
Claim 14
Dependent Claim
33 words
An ion-exchanger according to claim 10 wherein at least one of the groups R 1 , R 2 and R 3 is selected from the group of 2-hydroxyethyl, 2-hydroxypropyl and 2,3 dihydroxy propyl.
Claim 15
Dependent Claim
73 words
An ion-exchanger according to claim 10 wherein the dextran is cross-linked by bridges, which are bound to the dextran chains by either bonds, said bridges comprising straight or branched, aliphatic, saturated hydrocarbon chains being substituted with one or more hydroxyl groups, and containing 3-20 carbon atoms, and being broken by one or more oxygen atoms, no more than one oxygen atom being bound to one and the same carbon atom in the bridge.
Claim 16
Dependent Claim
29 words
An ion-exchanger according to claim 10 wherein the mean degree of substitution of the quaternary amino groups in the dextran or cross-linked dextran is within the range of 0.05-3.
Claim 17
Dependent Claim
29 words
An ion-exchanger according to claim 10 wherein the ion exchange capacity is in the range of 0.1-6 meq/g calculated per gram of dry product with chloride as counter ion.
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