US4590181A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Synthetic immunoregulators and methods of use and preparation
Assignee: BOARD OF REGENTS OF UNIVERSITY OF NEBRASKA A PUBLIC BODY CORPORATE OF
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Filing: 1982-12-20
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Granted: 1986-05-20
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Expires: 2002-12-20
Abstract
Abstract To regulate the immune response to an antigen, a subject is injected with the antigen and a polyanionic polysaccharide derivative having a molecular weight of between 10,000 and 600,000 selected to correspond to the antigen. For virus, as an example, mycodextran sulfate or pustulan sulfate may be used in sufficient quantities to stimulate cell-mediated immune responses without stimulating synthesis of gamma E globulin and gamma G globulin. The polyanionic polysaccharide may be injected along to stimulate cell-mediated immune responses to antigens in a diseased subject.
Inventors
- 👤 Robert E. McCarthy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 20:34
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/39; A61K2039/555; A61K2039/55511; A61K2039/55583; A61K2039/57
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
68 words
A composition adaptable for use as an injectable solution which comprises: a viral antigen and an adjuvant consisting essentially of a polysaccharide having a molecular weight from about 10,000 to 600,000 selected from the group consisting of pustulan and mycodextran wherein said polysaccharide has at least two anionic chemical groups attached thereto, which adjuvant stimulates a cell-mediated immune response to said viral antigen without stimulating other immune responses.
Claim 2
Dependent Claim
68 words
A composition adaptable for use as an injectable solution which comprises: a viral antigen and an adjuvant consisting essentially of a polysaccharide having a molecular weight from about 10,000 to 600,000 selected from the group consisting of pustulan and mycodextran wherein said polysaccharide has at least two anionic chemical groups attached thereto, which adjuvant stimulates a cell-mediated immune response to said viral antigen without stimulating other immune responses.
Claim 3
Dependent Claim
21 words
A composition according to claim 1 wherein said anionic chemical groups are selected from the group consisting of acetyl and sulfate.
Claim 4
Dependent Claim
74 words
A composition adaptable for use as an injectable solution which comprises: an adjuvant consisting essentially of a polysaccharide having a molecular weight from about 10,000 to 600,000 selected from the group consisting of pustulan and mycodextran wherein said polysaccharide has at least two anionic chemical groups attached thereto said anionic chemical groups being selected from the group consisting of acetyl and sulfate, which adjuvant stimulates a cell-mediated immune response without stimulating other immune responses.
Claim 5
Dependent Claim
74 words
A composition adaptable for use as an injectable solution which comprises: an adjuvant consisting essentially of a polysaccharide having a molecular weight from about 10,000 to 600,000 selected from the group consisting of pustulan and mycodextran wherein said polysaccharide has at least two anionic chemical groups attached thereto said anionic chemical groups being selected from the group consisting of acetyl and sulfate, which adjuvant stimulates a cell-mediated immune response without stimulating other immune responses.
Claim 6
Independent Claim
62 words
A method of immunizing a subject against a viral antigen comprising innoculating the subject with a polysaccharide having a molecular weight between 10,000 and 600,000 selected from the group consisting of pustulan and mycodextran wherein said polysaccharide has at least two anionic chemical groups attached thereto, which adjuvant stimulates a cell-mediated immune response to said viral antigen without stimulating other immune respones.
Claim 7
Independent Claim
62 words
A method of immunizing a subject against a viral antigen comprising innoculating the subject with a polysaccharide having a molecular weight between 10,000 and 600,000 selected from the group consisting of pustulan and mycodextran wherein said polysaccharide has at least two anionic chemical groups attached thereto, which adjuvant stimulates a cell-mediated immune response to said viral antigen without stimulating other immune respones.
References Cited (Backward Citations)
US4372883A
Cited
US4359458A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-05-19 | 1989-11-18 | 1990-05-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-05-19 | 1993-11-18 | 1994-05-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-05-19 | 1997-11-18 | 1998-05-20 | $7700.00 | Window Closed / Lapsed |