Agent facilitating liposome cellular wall transport, a method for the production thereof and its use

Claim 3

A method according to claim 1 wherein said aldehyde derivative metabolisable to said aldehyde is a compound in which urea is bound to an aldehyde of formula I or a compound deriving from urea or a compound deriving from urea wherein the oxygen is substituted by sulfur or a chemical substituent of the same effect or a compound wherein one or both NH 2 groups being replaced by a --S--(CH 2 ) m H group in which m is 0-25, or a group of the same fate in metabolism or a compound which can be regarded as a combination of the aldehyde of formula I with NH 3 or its derivatives, amino acids, amino sugars, sugars, 1,3-dioxolanes, 1,3-dioxanes, 1,3-dithiolanes, 1,3-dithianes, imidazolidines, oxazolidines, thiazolidines and compounds of aldehydes of formula I with vitamines, purine-bases or pyrimidinbases or nucleosides or nucleotides or their derivatives which through metabolism set free an aldehyde of formula I, semi-acetales or acetales of the aldehyde of formula I with alcohls of the formula H(CH 2 ) n OH in which n is 1 to 25 or their derivatives which through metabolism set free an aldehyde of formula I or mixtures thereof.

Claim 4

A method according to claim 1 wherein said chemical compound metabolisable to said aldehyde is a compound of the formula R"-S-R'" in which R" is a straight-chain or branched hydrocarbon group having 1 to 4 carbon atoms and in which R'" is H or the same as R", or a compound of the formula R"-S-S-R" wherein R" has the meaning given above.

Claim 5

A method according to claim 1 wherein the aldehyde and the alcohol are employed in combination with a peroxide.

Claim 6

A method according to claim 4 wherein R and R' are methyl.

Claim 7

A method according to claim 5 wherein 11 to 40 g of aldehyde per 1,000 g of alcohol is employed.

Claim 8

A method according to claim 6 wherein 15 to 30 g of aldehyde per 1,000 g of alcohol is employed.

Claim 9

A method according to claim 1 wherein a liposome is thereafter administered.

Claim 10

A method according to claim 8 wherein the liposome carries a dyestuff, a radioactive tracer, a radioactive tracer and a dyestuff, a cytostatic, a radioactive radiator, a radioactive radiator and/or an immune modulator, or a cytostatic and a radioactive radiator.

Claim 11

A method according to claim 1 wherein the administration of aldehyde and alcohol is oral or parenteral.

Claim 12

A method according to claim 2 wherein the administration of the liposome is oral or parenteral.

Claim 13

A method according to claim 1 wherein the aldehyde is administered orally and the liposome is administered by inhalation.

Claim 14

A method according to claim 1 wherein the liposome is administered with an agent adapted to increase the deoxygenation in the region of a malignant tumor.

Claim 15

A method according to claim 13 wherein the agent for increasing the deoxygenation is an inositol phosphate or glycerine phosphate.

Claim 16

A method according to claim 2 in which m is 0-4 and in which n in the formula H(CH 2 ) n OH is 1-4.

Claim 17

A kit comprising a container of a first reagent and a container of a second reagent, said first reagent comprising a liposome cellular wall transport facilitating amount of an aldehyde of formula I RCHO (I) in which R is a hydrogen atom or a straight-chain or branched hydrocarbon group having 1 to 4 carbon atoms or an aldehyde derivative or a chemical compound metabolisable to said aldehyde in combination with an alcohol of formula II R'CH.sub.2 OH (II) in which R' is a hydrogen atom or a straight-chain or branched hydrocarbon group having 1 to 4 carbon atoms, and said second reagent comprising a pharmaceutically acceptable carrier and a liposome.

Claim 18

A kit comprising a container of a first reagent and a container of a second reagent, said first reagent comprising a liposome cellular wall transport facilitating amount of an aldehyde of formula I RCHO (I) in which R is a hydrogen atom or a straight-chain or branched hydrocarbon group having 1 to 4 carbon atoms or an aldehyde derivative or a chemical compound metabolisable to said aldehyde in combination with an alcohol of formula II R'CH.sub.2 OH (II) in which R' is a hydrogen atom or a straight-chain or branched hydrocarbon group having 1 to 4 carbon atoms, and said second reagent comprising a pharmaceutically acceptable carrier and a liposome.

Claim 19

A kit according to claim 16 wherein said first reagent further comprises a peroxide.

Claim 20

A kit according to claim 17 in which said peroxide is hydrogen peroxide.

Claim 21

A kit according to claim 16, further comprising a container of a third reagent which comprises a pharmaceutically acceptable carrier and an agent adapted to increase the deoxygenation in the region of a malignant tumor.

Claim 22

A kit according to claim 16 wherein said aldehyde derivative metabolisable to said aldehyde is a compound in which urea is bound to an aldehyde of formula I or a compound deriving from urea or a compound deriving from urea wherein the oxygen is substituted by sulfur or a chemical substituent of the same effect or a compound wherein one or both NH 2 groups being replaced by a --S--(CH 2 ) m H group in which m is 0-25 or a group of the same fate in metabolism or a compound which can be regarded as a combination of the aldehyde of formula I with NH 3 or its derivatives, amino acids, amino sugars, sugars, 1,3-dioxolanes, 1,3-dioxanes, 1,3-dithiolanes, 1,3-dithianes, imidazolidines, oxazolidines, thiazolidines and compounds of aldehydes of formula I with vitamines, purinebases or pyrimidinebases or nucleosides or nucleotides or their derivatives which through metabolism set free an aldehyde of formula I, semi-acetales or acetales of the aldehyde of formula I with alcohols of the formula H(CH 2 ) n OH in which n is 1 to 25 or their derivatives which through metabolism set free an aldehyde of formula I, or mixtures thereof.

Claim 23

A kit according to claim 16 wherein said chemical compound metabolisable to said aldehyde is a compound of the formula R"-S-R"'in which R" is a straight-chain or branched hydrocarbon group having 1 to 4 carbon atoms and in which R'" is H or the same as R", or a compound of the formula R"-S-S-R" wherein R" has the meaning given above.

Claim 24

A kit according to claim 16 wherein R and R' have the same number of carbon atoms.

Claim 25

A kit according to claim 22 wherein the aldehyde and the alcohol are formaldehyde/methanol, acetaldehyde/ethanol, n-propionaldehyde/n-propanol, isopropionaldehyde/isopropanol, n-butyraldehyde/n-butanol, isobutyraldehyde/isobutanol, tert.-butyraldehyde/tert.-butanol, n-valeraldehyde/n-pentanol or mixtures thereof.

Claim 26

A kit according to claim 23 containing 11 to 40 g of aldehyde per 1,000 g of alcohol.

Claim 27

A kit according to claim 24 containing 15 to 30 g of aldehyde per 1,000 g of alcohol.

Claim 28

A kit according to claim 16 wherein the aldehyde is acetaldehyde and the alcohol is ethanol.