US4588726A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-quinolinecarboxylic acid antibacterial agents
Assignee: Bayer AG
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Filing: 1985-05-17
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Granted: 1986-05-13
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Expires: 2005-05-17
Abstract
Abstract Novel antibacterially active 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-quinolinecarboxylic acids of the formula ##STR1## in which R 1 is hydrogen, methyl or ethyl, and R 2 is hydrogen or fluorine, and pharmaceutically tolerable hydrates and salts thereof.
Inventors
- 👤 Uwe Petersen
- 👤 Klaus Grohe
- 👤 Hans-Joachim Zeiler
- 👤 Karl G. Metzger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 00:10
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D215/00; C07D215/02; C07D215/16; C07D215/48; C07D215/54; C07D215/56; A; A61; A61P; A61P3/00; A61P31/00; A61P31/04; C07D401/04
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
31 words
A 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-quinolinecarboxylic acid of the formula ##STR11## in which R 1 is hydrogen, methyl or ethyl, and R 2 is hydrogen or fluorine, or a pharmaceutically tolerable hydrate or salt thereof.
Claim 2
Dependent Claim
31 words
A 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-quinolinecarboxylic acid of the formula ##STR11## in which R 1 is hydrogen, methyl or ethyl, and R 2 is hydrogen or fluorine, or a pharmaceutically tolerable hydrate or salt thereof.
Claim 3
Dependent Claim
20 words
A compound according to claim 1, wherein such compound is 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-4-quinolinecarboxylic acid or a pharmaceutically tolerable hydrate or salt thereof.
Claim 4
Dependent Claim
20 words
A compound according to claim 1, wherein such compound is 1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-quinolinecarboxylic acid or a pharmaceutically tolerable hydrate or salt thereof.
Claim 5
Dependent Claim
23 words
An antibacterial composition comprising an antibacterially effective amount of a compound, hydrate or salt according to claim 1 in admixture with a diluent.
Claim 6
Dependent Claim
19 words
A unit dose of a composition according to claim 4 in the form of a tablet, capsule or ampule.
Claim 7
Dependent Claim
20 words
A composition according to claim 4, wherein such compound is 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-4-quinolinecarboxylic acid or a pharmaceutically tolerable hydrate or salt thereof.
Claim 8
Dependent Claim
20 words
A composition according to claim 4, wherein such compound is 1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-quinolinecarboxylic acid or a pharmaceutically tolerable hydrate or salt thereof.
Claim 9
Dependent Claim
32 words
A method of combating bacteria which comprises applying to such bacteria or to a bacterial host or habitat an antibacterially effective amount of a compound, hydrate or salt according to claim 1.
Claim 10
Dependent Claim
20 words
The method according to claim 8, wherein such compound is 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-4-quinolinecarboxylic acid or a pharmaceutically tolerable hydrate or salt thereof.
Claim 11
Dependent Claim
20 words
The method according to claim 8, wherein such compound is 1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-quinolinecarboxylic acid or a pharmaceutically tolerable hydrate or salt thereof.
References Cited (Backward Citations)
FR2437406A1
Cited
US4448962A
Cited
EP0049355B1
Cited
US4398029A
Cited
US4398029B1
Cited
US4544658A
Cited
DE3306771A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-05-12 | 1989-11-11 | 1990-05-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-05-12 | 1993-11-11 | 1994-05-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-05-12 | 1997-11-11 | 1998-05-13 | $7700.00 | Window Closed / Lapsed |