US4582909A
Expired / Lapsed
US
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Benzobicyclic lactam acids and derivatives as cognition activators
Assignee: Warner Lambert Co LLC
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Filing: 1984-02-02
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Granted: 1986-04-15
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Expires: 2004-02-02
Abstract
Abstract Benzobicyclic lactam acids having a fused aromatic carbocyclic and a saturated lactam ring of five- or six-members, their salts, esters, and amides, are useful for reversing amnesia. Pharmaceutical compositions including these compounds, a method of preparing the compounds, and a method of treating senility and reversing amnesia are also disclosed.
Inventors
- 👤 Donald E. Butler
- 👤 Michael R. Pavia
- 👤 Fred M. Hershenson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:49
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/20; C07D215/22; C07D215/227; A; A61; A61P; A61P25/00; A61P25/28; A61P43/00; C07C; C07C205/00; C07C205/49; C07C205/56; C07D209/00; C07D209/02; C07D209/04; C07D209/30; C07D209/32; C07D209/34; C07D209/38; C07D401/00; C07D401/02; C07D401/12; C07D405/00; C07D405/02; C07D405/04; C07D455/00; C07D455/03; C07D455/04; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
86 words
A compound having the formula ##STR9## wherein x [, and y are independently zero or ] is zero and y is zero or one; R is hydrogen; hydrogen, hydroxyl; --OR 1 where R 1 is alkyl of from one to six carbon atoms, phenyl, or phenylmethyl; or --NR 2 R 3 where R 2 and R 3 are independently alkyl of from one to six carbon atoms; R 4 is selected from --OH, together with the pharmaceutically acceptable metal, ammonium, and amine acid addition salts thereof;
Claim 2
Dependent Claim
86 words
A compound having the formula ##STR9## wherein x [, and y are independently zero or ] is zero and y is zero or one; R is hydrogen; hydrogen, hydroxyl; --OR 1 where R 1 is alkyl of from one to six carbon atoms, phenyl, or phenylmethyl; or --NR 2 R 3 where R 2 and R 3 are independently alkyl of from one to six carbon atoms; R 4 is selected from --OH, together with the pharmaceutically acceptable metal, ammonium, and amine acid addition salts thereof;
Claim 3
Dependent Claim
59 words
--OR 1 , where R 1 is as previously defined; and R 5 is hydrogen or ##STR10## where R 8 and R 9 are independently hydrogen; halogen; hydroxyl; OR 1 where R 1 is as defined above, NR 1O R 11 where R 1O and R 11 are independently hydrogen, or alkyl of from one to six carbon atoms.
Claim 4
Dependent Claim
59 words
--OR 1 , where R 1 is as previously defined; and R 5 is hydrogen or ##STR10## where R 8 and R 9 are independently hydrogen; halogen; hydroxyl; OR 1 where R 1 is as defined above, NR 1O R 11 where R 1O and R 11 are independently hydrogen, or alkyl of from one to six carbon atoms.
Claim 5
Dependent Claim
14 words
A compound in accordance with claim 1 wherein x and y are both zero.
Claim 6
Dependent Claim
15 words
A compound in accordance with claim 1 wherein x is zero and y is one.
Claim 7
Dependent Claim
54 words
A compound in accordance with claim 1 wherein R is selected from hydrogen; fluorine, chlorine; hydroxy; --OR 1 wherein R 1 is alkyl of from one to six carbon atoms, phenyl, or phenylmethyl; or --NR 2 R 3 where R 2 and R 3 are independently alkyl of from one to six carbon atoms.
Claim 8
Dependent Claim
18 words
A compound in accordance with claim 1 wherein R 4 is --OH, and the pharmaceutically acceptable salts thereof.
Claim 9
Dependent Claim
28 words
A compound in accordance with claim 1 wherein R 4 is --OR 1 wherein R 1 is alkyl of from one to six carbon atoms, phenyl, or phenylmethyl.
Claim 10
Dependent Claim
18 words
A compound in accordance with claim 1 having the name 2,3-dihydro-2-oxo-1H-indole-7-acetic acid and the pharmaceutically acceptable salts thereof.
Claim 11
Dependent Claim
18 words
A compound in accordance with claim 1 having the name 2,3-dihydro-1-(3-methoxybenzoyl)-2-oxo-1H-indole-7-acetic acid and the pharmaceutically acceptable salts thereof.
Claim 12
Dependent Claim
18 words
A compound in accordance with claim 1 having the name 2,3-dihydro-1-(4-methoxybenzoyl)-2-oxo-1H-indole-7-acetic acid and the pharmaceutically acceptable salts thereof.
Claim 13
Dependent Claim
18 words
A compound in accordance with claim 1 having the name 2,3-dihydro-1-(4-methoxybenzoyl)-2-oxo-1H-indole-7-propanoic acid and the pharmaceutically acceptable salts thereof.
Claim 14
Dependent Claim
18 words
A compound in accordance with claim 1 having the name 2,3-dihydro-1-(4-hydroxy-3-methylbenzoyl)-2-oxo-1H-indole-7-acetic acid and the pharmaceutically acceptable salts thereof.
Claim 15
Dependent Claim
18 words
A compound in accordance with claim 1 having the name 2,3-dihydro-2-oxo-1H-indole-7-propanoic acid and the pharmaceutically acceptable salts thereof.
Claim 16
Dependent Claim
18 words
A compound in accordance with claim 1 having the name 1-benzoyl-2-3-dihydro-2-oxo-1H-indole-7-acetic acid and the pharmaceutically acceptable salts thereof.
Claim 17
Dependent Claim
18 words
A compound in accordance with claim 1 having the name 2,3-dihydro-1-(3-hydroxy-4-methoxybenzoyl)-2-oxo-1H-indole-7-acetic acid and the pharmaceutically acceptable salts thereof.
Claim 18
Dependent Claim
14 words
A compound in accordance with claim 1 having the name 2,3-dihydro-2-oxo-1H-indole-7-acetic acid methyl ester.
Claim 19
Dependent Claim
14 words
A compound in accordance with claim 1 having the name 2,3-dihydro-2-oxo-1H-indole-7-acetic acid phenylmethyl ester.
Claim 20
Dependent Claim
14 words
A compound in accordance with claim 1 having the name 2,3-dihydro-2-oxo-1H-indole-7-propanoic acid methyl ester.
Claim 21
Dependent Claim
14 words
A compound in accordance with claim 1 having the name 2,3-dihydro-2-oxo-1H-indole-7-propanoic acid phenylmethyl ester.
Claim 22
Dependent Claim
14 words
A compound in accordance with claim 1 having the name 1-(2-chlorobenzoyl)-5-fluoro-2,3-dihydro-2-oxo-1H-indole-7-propanoic acid methyl ester.
References Cited (Backward Citations)
US4216220A
Cited
US4313947A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-04-14 | 1989-10-14 | 1990-04-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-14 | 1993-10-14 | 1994-04-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-14 | 1997-10-14 | 1998-04-15 | $7700.00 | Window Closed / Lapsed |