US4582847A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4-chloro-2-phenylimidazole-5-acetic acid derivatives and use as diuretics and hypotensives
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1983-03-14
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Granted: 1986-04-15
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Expires: 2003-03-14
Abstract
Abstract Compounds of the formula ##STR1## wherein R is lower alkyl, and salts thereof. These compounds have excellent diuretic and antihypertensive actions in mammalian animals and are of use as therapeutic drugs for the treatment of edema and hypertension.
Inventors
- 👤 Yoshiyasu Furukawa
- 👤 Kohei Nishikawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 13:30
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/66; C07D233/68; A; A61; A61P; A61P7/00; A61P7/10; A61P9/00; A61P9/12; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
15 words
A compound of the formula ##STR9## wherein R is lower alkyl, or a salt thereof.
Claim 2
Dependent Claim
15 words
A compound of the formula ##STR9## wherein R is lower alkyl, or a salt thereof.
Claim 3
Dependent Claim
10 words
A compound according to claim 1, wherein R is methyl.
Claim 4
Dependent Claim
14 words
A compound according to claim 1, wherein the salt is an alkaline metal salt.
Claim 5
Dependent Claim
10 words
A compound according to claim 1, which is 4-chloro-1-(4-hydroxy-3-methylbenzyl)-2-phenylimidazole-5-acetic acid.
Claim 6
Dependent Claim
28 words
A pharmaceutical composition which contains an effective amount for producing diuretic activity in a mammal of a compound of claim 1 and a carrier, vehicle or diluent therefor.
Claim 7
Dependent Claim
28 words
A pharmaceutical composition which contains an effective amount for producing hypotensive activity in a mammal of a compound of claim 2 and a carrier, vehicle or diluent therefor.
Claim 8
Dependent Claim
24 words
A method for producing hypotensive activity in a mammal, which comprises administering to said mammal an effective amount of a compound of claim 1.
Claim 9
Dependent Claim
24 words
A method for producing hypotensive activity in a mammal, which comprises administering to said mammal an effective amount of a compound of claim 2.
Claim 10
Dependent Claim
24 words
A method for producing hypotensive activity in a mammal, which comprises administering to said mammal an effective amount of a compound of claim 3.
Claim 11
Dependent Claim
24 words
A method for producing hypotensive activity in a mammal, which comprises administering to said mammal an effective amount of a compound of claim 4.
Claim 12
Dependent Claim
24 words
A method for producing diuretic activity in a mammal, which comprises administering to said mammal an effective amount of a compound of claim 1.
Claim 13
Dependent Claim
24 words
A method for producing diuretic activity in a mammal, which comprises administering to said mammal an effective amount of a compound of claim 2.
Claim 14
Dependent Claim
24 words
A method for producing diuretic activity in a mammal, which comprises administering to said mammal an effective amount of a compound of claim 3.
Claim 15
Dependent Claim
24 words
A method for producing diuretic activity in a mammal, which comprises administering to said mammal an effective amount of the compound of claim 4.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-04-14 | 1989-10-14 | 1990-04-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-14 | 1993-10-14 | 1994-04-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-14 | 1997-10-14 | 1998-04-15 | $7700.00 | Window Closed / Lapsed |