US4582840A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1,4-dihydro-2,6-dimethyl-4-nitrophenyl-3,5-pyridinedicarboxylic acid esters useful for treating renal insufficiency
Assignee: Bayer AG
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Filing: 1985-04-25
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Granted: 1986-04-15
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Expires: 2005-04-25
Abstract
Abstract A method of combating a disorder of the salt balance in a patient afflicted therewith comprising administering to such patient a salt-balance restoring effective amount of a vasodilating 1,4-dihydropyridine of the formula ##STR1## in which R 1 and R 2 each independently is alkyl with 1 to 4 carbon atoms, and the nitro radical is in the ortho- or meta-position of the phenyl radical. The salt balance disorder may accompany the hypertensive disease or may also be aggravated by administering to such a patient a hypertension reducing agent.
Inventors
- 👤 Bernward Garthoff
- 👤 Stanislav Kazda
- 👤 Andreas Knorr
- 👤 Gunter Thomas
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 09:36
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61P; A61P7/00; A61P7/10
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
64 words
A method of combating sodium inbalance renal insufficiency in a normotensive patient afflicted therewith comprising administering to such patient a sodium inbalance renal sufficiency-restoring effective amount of a 1,4-dihydropyridine of the formula ##STR3## in which R 1 and R 2 each independently is alkyl with 1 to 4 carbon atoms, and the nitro radical is in the ortho- or meta-position of the phenyl radical.
Claim 2
Independent Claim
64 words
A method of combating sodium inbalance renal insufficiency in a normotensive patient afflicted therewith comprising administering to such patient a sodium inbalance renal sufficiency-restoring effective amount of a 1,4-dihydropyridine of the formula ##STR3## in which R 1 and R 2 each independently is alkyl with 1 to 4 carbon atoms, and the nitro radical is in the ortho- or meta-position of the phenyl radical.
Claim 3
Dependent Claim
11 words
The method according to claim 1, wherein the dihydropyridine is nitrendipine.
Claim 4
Dependent Claim
11 words
The method according to claim 1, wherein the dihydropyridine is nifedipine.
Claim 5
Dependent Claim
11 words
The method according to claim 1, wherein the dihydropyridine is nisoldipine.
Claim 6
Dependent Claim
20 words
The method according to claim 1, wherein the dihydropyridine is administered in about 0.05 to 10 mg/kg of body weight/day.
Claim 7
Dependent Claim
15 words
The method according to claim 1, in which R 1 and R 2 are identical.
Claim 8
Dependent Claim
15 words
The method according to claim 1, in which R 1 and R 2 are different.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-04-14 | 1989-10-14 | 1990-04-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-14 | 1993-10-14 | 1994-04-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-14 | 1997-10-14 | 1998-04-15 | $7700.00 | Window Closed / Lapsed |