US4579858A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Smoking substitutes for nasal administration-I
Assignee: LEO A SWEDISH CORP AB
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Filing: 1984-01-11
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Granted: 1986-04-01
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Expires: 2004-01-11
Abstract
Abstract A smoking substitute composition for application directly into the nose, consisting essentially of an aqueous solution of nicotine or a physiologically acceptable acid addition salt thereof, having a pH value of 2 to 6, containing 10 to 0.5% w/v of nicotine calculated as the free base, containing a nasally-acceptable thickening agent, and having a viscosity not less than 100 centipoise and optionally containing also a further ingredient selected from the group consisting of a nasally acceptable buffer, emulsifying agent, preservative, flavoring agent and antioxidant. A method of diminishing the desire of a subject to smoke comprising the step of administering to the subject a smoking substitute composition as set forth in the foregoing.
Inventors
- 👤 Ove B. Ferno
- 👤 Stig K. A. Helgertz
- 👤 Corfitz B. I. Ohlsson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 15:28
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/465; A61K9/00; A61K9/0012; A61K9/0043; B; B65; B65D; B65D47/00; B65D47/04; B65D47/06
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
74 words
A smoking substitute composition for application directly into the nose, consisting essentially of an aqueous solution of nicotine or a physiologically acceptable acid addition salt thereof, having a pH value of 2 to 6, containing 10 to 0.5% w/v of nicotine calculated as the free base, containing a nasally-acceptable thickening agent, having a viscosity not less than 100 centipose, and having about 0.5 to 5 mg nicotine per every 0.05 to 0.5 ml thereof.
Claim 2
Dependent Claim
74 words
A smoking substitute composition for application directly into the nose, consisting essentially of an aqueous solution of nicotine or a physiologically acceptable acid addition salt thereof, having a pH value of 2 to 6, containing 10 to 0.5% w/v of nicotine calculated as the free base, containing a nasally-acceptable thickening agent, having a viscosity not less than 100 centipose, and having about 0.5 to 5 mg nicotine per every 0.05 to 0.5 ml thereof.
Claim 3
Dependent Claim
31 words
A composition of claim 1 in a unit dosage form comprising 0.05 up to 0.5 ml of said aqueous solution which delivers about 0.5 to 5 mg nicotine per unit dose.
Claim 4
Dependent Claim
13 words
A composition of claim 1, having a viscosity not less than 1,000 centipoise.
Claim 5
Dependent Claim
24 words
A composition of claim 3, containing an effective amount of nasally-acceptable buffer having a buffering effect in the range of pH 2 to 6.
Claim 6
Dependent Claim
20 words
A composition of claim 4, wherein the buffer has a buffering effect in the range of pH 4 to 6.
Claim 7
Dependent Claim
13 words
A composition of claim 3, having a viscosity not higher than 6,000 centipoise.
Claim 8
Dependent Claim
16 words
A composition of claim 1, wherein the thickening agent is a nasally-acceptable natural or synthetic polymer.
Claim 9
Dependent Claim
20 words
A composition of claim 1, wherein the thickening agent is a nasally-acceptable oily substance constituting the oil-phase of an emulsion.
Claim 10
Dependent Claim
10 words
A composition of claim 8, also comprising an emulsifying agent.
Claim 11
Dependent Claim
13 words
A composition of claim 1, having a pH value of 3 to 5.
Claim 12
Dependent Claim
12 words
A composition of claim 1, containing 5 to 1% w/v of nicotine.
Claim 13
Dependent Claim
12 words
A composition of claim 11, containing 4 to 2% w/v of nicotine.
Claim 14
Dependent Claim
15 words
A composition of claim 1, wherein the aqueous solution is 0.05 up to 0.3 ml.
Claim 15
Dependent Claim
15 words
A composition of claim 1, containing also an effective amount of a nasally-acceptable preservative agent.
Claim 16
Dependent Claim
15 words
A composition of claim 1, containing also an effective amount of a nasally-acceptable flavoring agent.
Claim 17
Dependent Claim
14 words
A composition of claim 1, containing also an effective amount of a nasally-acceptable antioxidant.
Claim 18
Dependent Claim
69 words
A composition of claim 2, wherein the composition is in unit dosage form in a disposable plastic container having a nostril-insertable neck portion of restrictive volume adjacent to an emission opening and a pressure-application chamber of a relatively larger volume in communication with said neck portion, wherein the said composition is disposed in said neck portion and of sufficient viscosity to retain said location until the time of application.
Claim 19
Dependent Claim
44 words
A composition of claim 17, wherein the nostril-insertable container neck is itself dimensioned so as to contain a unit dose and wherein a squeeze-bottle container constitutes the relatively larger pressure application chamber, the unit dose neck thus constituting a portion of a multi-dose container.
Claim 20
Independent Claim
34 words
A method of diminishing the desire of a subject to smoke, which comprises the step of administering to the subject intranasally a smoking substitute composition according to any one of claims 1 through 18.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-03-31 | 1989-09-30 | 1990-04-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-31 | 1993-09-30 | 1994-04-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-31 | 1997-09-30 | 1998-04-01 | $7700.00 | Window Closed / Lapsed |