US4576928A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Adsorbent and process for preparing the same
Assignee: Kanegafuchi Chemical Industry Co Ltd
•
Filing: 1983-12-01
•
Granted: 1986-03-18
•
Expires: 2003-12-01
Abstract
Abstract Adsorbent for removing a harmful substance to be removed from body fluid such as blood or plasma composed of a porous hard gel on which a ligand having an affinity for the harmful substance is immobilized. The adsorbent is suitable for selective removal of harmful substances such as VLDL, LDL, harmful proteins, viruses and harmful cells, in extracorporeal circulation treatment.
Inventors
- 👤 Nobutaka Tani
- 👤 Tsuneo Hayashi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 05:16
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; B; B01; B01J; B01J20/00; B01J20/30; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3206; B01J20/3208; B01J20/3212; B01J20/3214; B01J20/3217; B01J20/3219; B01J20/3231; B01J20/3242; B01J20/3268; B01J20/327; B01J20/3272; B01J20/3274; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0415; A61M2202/0456; A61M2202/046
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
65 words
An adsorbent for removing a substance to be removed from body fluid in extracorporeal circulation treatment comprising a porous cellulose gel on which a ligand having an affinity for the substance is immobilized by a covalent linkage by reacting the porous cellulose gel with epichorohydrin or a polyoxirane compound to introduce epoxy groups into the gel and reacting the resulting epoxy-activated gel with the ligand.
Claim 2
Dependent Claim
65 words
An adsorbent for removing a substance to be removed from body fluid in extracorporeal circulation treatment comprising a porous cellulose gel on which a ligand having an affinity for the substance is immobilized by a covalent linkage by reacting the porous cellulose gel with epichorohydrin or a polyoxirane compound to introduce epoxy groups into the gel and reacting the resulting epoxy-activated gel with the ligand.
Claim 3
Dependent Claim
12 words
The adsorbent of claim 1, wherein said ligand is a polyanion compound.
Claim 4
Dependent Claim
13 words
The adsorbent of claim 2, wherein said polyanion compound is a sulfated polysaccharide.
Claim 5
Dependent Claim
26 words
The adsorbent of claim 3, wherein said sulfated polysaccharide is a member selected from the group consisting of heparin, dextran sulfate, chondroitin sulfate, and their salts.
Claim 6
Dependent Claim
14 words
The adsorbent of claim 1, wherein said substance to be removed is a lipoprotein.
Claim 7
Dependent Claim
22 words
The adsorbent of claim 5, wherein an exclusion limit of the porous cellulose gel is from 10 6 to 10 9 daltons.
Claim 8
Dependent Claim
16 words
The adsorbent of claim 6, wherein said exclusion limit is 10 6 to 10 8 daltons.
Claim 9
Dependent Claim
20 words
The adsorbent of claim 5, wherein said lipoprotein is very low density lipoprotein, low density lipoprotein or an admixture thereof.
Claim 10
Dependent Claim
34 words
The adsorbent of claim 1, comprising a porous cellulose gel having an exclusion limit of 10 6 to 10 8 daltons on which a polyanion compound having an affinity for a lipoprotein is immobilized.
Claim 11
Dependent Claim
23 words
The adsorbent of claim 1, wherein said polyanion compound is immobilized in an amount of 0.02 mg to 100 mg/ml of bed volume.
Claim 12
Dependent Claim
43 words
The adsorbent of claim 4, wherein said dextran sulfate, a salt thereof or a mixture of the dextran sulfate and the salt has an intrinsic viscosity of not more than 0.12 dl/g and a sulfur content of not less than 15% by weight.
Claim 13
Dependent Claim
36 words
The adsorbent of claim 4, wherein said dextran sulfate, a salt thereof or a mixture of the dextran sulfate and th salt is immobilized in an amount of not less than 0.2 mg/ml of bed volume.
Claim 14
Dependent Claim
32 words
The adsorbent of claim 1, wherein a dextran sulfate, a salt thereof or amixture of the dextran sulfate and the salt is immobilized on a porous cellulose gel by the covalent linkage.
Claim 15
Dependent Claim
64 words
A process of preparing an adsorbent for removing a substance to be removed from body fluid in extracorporeal circulation treatment which comprises immobilizing a ligand having an affinity for the substance on a porous cellulose gel by reacting the porous cellulose gel with epichlorohydrin of a polyoxirane compound to introduce eposy groups into the gel and reacting the resulting epoxy-acitvated gel with the ligand.
Claim 16
Dependent Claim
64 words
A process of preparing an adsorbent for removing a substance to be removed from body fluid in extracorporeal circulation treatment which comprises immobilizing a ligand having an affinity for the substance on a porous cellulose gel by reacting the porous cellulose gel with epichlorohydrin of a polyoxirane compound to introduce eposy groups into the gel and reacting the resulting epoxy-acitvated gel with the ligand.
Claim 17
Dependent Claim
72 words
The process of claim 14, wherein said ligand is dextran slufate, a salt thereof or a mixture of the dextran sulfate and the salt, said dextran sulfate, the salt thereof or the mixture of the dextran sulfate and the salt being reacted with said epoxy-activated gel in a concentration of not less than 3% based on the weight of the whole reaction system excluding the dry weight of the porous hard gel.
References Cited (Backward Citations)
US3983053A
Cited
US3947352A
Cited
US4061591A
Cited
US4111838A
Cited
US4268419A
Cited
US4432871A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-03-17 | 1989-09-16 | 1990-03-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-17 | 1993-09-16 | 1994-03-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-17 | 1997-09-16 | 1998-03-18 | $7700.00 | Window Closed / Lapsed |