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US4576819A Expired / Lapsed US ⏱️ 0.0 years remaining

Aluminum hydroxide gel, process for production thereof, and use thereof

Assignee: Kyowa Chemical Industry Co Ltd
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Filing: 1983-11-22
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Granted: 1986-03-18
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Expires: 2003-11-22
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Abstract

Abstract An aluminum hydroxide gel of the following formula [CaO, MgO, M2O]x.Al2O3.(CO2)y.mH2O wherein M represents an alkali metal, M2O may be zero, CaO and MgO are not zero at the same time, and x, y and m are positive numbers represented by the following expressions 0<x<1, 0.2<y>/=1, 2>/=m<10. Said aluminum hydroxide gel can be produced by reacting an aluminum compound soluble in water and/or lower alcohols with a carbonate ion yielding compound soluble in water and/or lower alcohols at a pH of about 6 to about 9.5 under such conditions that the CO2/Al mole ratio of the resulting aluminum hydroxide gel is at least about 0.1, and ion exchanging the alkali metals of the resulting compound with magnesium and/or calcium. This invention also provides an antacid composition comprising said aluminum hydroxide gel as an active ingredient.

Inventors

  • 👤 Shigeo Miyata
  • 👤 Tsutomu Nosu

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-05 10:05
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/06; C; C01; C01F; C01F7/00; C01F7/78; C01F7/784; C01F7/785; C01P; C01P2002/00; C01P2002/20; C01P2002/22

Claims Analysis

Total Claims: 3
Claim 1
Independent Claim 200 words
An amorphous aluminum hydroxide gel of formula (I) in which Ca and/or Mg are bonded to the compound of formula (I) by ion-exchange with an alkali metal, (CaO, MgO, M.sub.2 O).sub.x.Al.sub.2 O.sub.3.(CO.sub.2).sub.y.mH.sub.2 O (I) wherein M represents an alkali metal, M 2 O may be zero, CaO and MgO are not zero at the same time and x, y and m are positive numbers represented by the following expressions 0.1≦x<0.8, 0.4≦y≦0.8, 2≦m<10 said amorphous aluminum hydroxide gel being produced by the process which comprises reacting an aluminum compound soluble in water and/or lower alcohols selected from the group consisting of aluminum chloride, aluminum nitrate, aluminum sulfate, aluminum metal, aluminum ammonium sulfate, aluminum bromide, aluminum fluoride, aluminum potassium sulfate, aluminum isopropoxide, sodium aluminate, potassium aluminate, and aluminum sodium sulfate, with a carbonate ion yielding compound soluble in water and/or lower alcohols selected from the group consisting of sodium carbonate, potassium carbonate, sodium hydrogen carbonate and potassium hydrogen carbonate, at a pH of about 6 to about 9.5 under such conditions that the CO 2 /Al mole ratio of the resulting aluminum hydroxide gel is about 0.1-about 8, and ion exchanging the alkali metals of the resulting compound with magnesium and/or calcium.
Claim 2
Dependent Claim 200 words
An amorphous aluminum hydroxide gel of formula (I) in which Ca and/or Mg are bonded to the compound of formula (I) by ion-exchange with an alkali metal, (CaO, MgO, M.sub.2 O).sub.x.Al.sub.2 O.sub.3.(CO.sub.2).sub.y.mH.sub.2 O (I) wherein M represents an alkali metal, M 2 O may be zero, CaO and MgO are not zero at the same time and x, y and m are positive numbers represented by the following expressions 0.1≦x<0.8, 0.4≦y≦0.8, 2≦m<10 said amorphous aluminum hydroxide gel being produced by the process which comprises reacting an aluminum compound soluble in water and/or lower alcohols selected from the group consisting of aluminum chloride, aluminum nitrate, aluminum sulfate, aluminum metal, aluminum ammonium sulfate, aluminum bromide, aluminum fluoride, aluminum potassium sulfate, aluminum isopropoxide, sodium aluminate, potassium aluminate, and aluminum sodium sulfate, with a carbonate ion yielding compound soluble in water and/or lower alcohols selected from the group consisting of sodium carbonate, potassium carbonate, sodium hydrogen carbonate and potassium hydrogen carbonate, at a pH of about 6 to about 9.5 under such conditions that the CO 2 /Al mole ratio of the resulting aluminum hydroxide gel is about 0.1-about 8, and ion exchanging the alkali metals of the resulting compound with magnesium and/or calcium.
Claim 3
Dependent Claim 26 words
An antacid composition comprising an antacid effective amount of an amorphous aluminum hydroxide gel as defined in claim 1 and a pharmaceutically acceptable diluent or carrier.

References Cited (Backward Citations)

US2880136A Cited
US2958626A Cited
US3099554A Cited
US3239446A Cited
US3272773A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1989-03-17 1989-09-16 1990-03-18 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1993-03-17 1993-09-16 1994-03-18 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1997-03-17 1997-09-16 1998-03-18 $7700.00 Window Closed / Lapsed

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