US4576793A
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Analytical element
Assignee: Konica Minolta Inc
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Filing: 1983-08-29
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Granted: 1986-03-18
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Expires: 2003-08-29
Abstract
Abstract There is disclosed an analytical element comprising a support; a reagent layer which is positioned on one side of the support and contains a reagent reactive with a component in a fluid sample; and a porous spreading layer which is positioned on the reagent layer on the opposite side to that of the support for permitting the component in the fluid sample to permeate into the reagent layer; wherein at least one layer contains 5% by weight or more of a polymer formed by, (i) a copolymerizable ethylenically unsaturated acid with (ii) a copolymerizable ethylenically unsaturated monomer. The analytical element according to the present invention can determine a component in a fluid sample quantitatively.
Inventors
- 👤 Mikio Koyama
- 👤 Kenichiro Okaniwa
- 👤 Masakuni Saruhashi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 18:05
CPC Classifications
G; G01; G01N; G01N31/00; G01N31/22; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/525; Y; Y10; Y10S; Y10S435/00; Y10S435/805; Y10T; Y10T436/00; Y10T436/17; Y10T436/172307
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
121 words
An analytical element comprising a support layer having an upper side and a lower side, a reagent layer which is positioned on one of said sides of said support and contains a reagent reactive with a component in a fluid sample, and a porous spreading layer which is positioned on the reagent layer on the opposite side to said support for permitting the component in said fluid sample to permeate into said reagent layer; wherein at least one of said layers contains at least 5% by weight of a copolymer formed by the polymerization of (i) at least 45% by weight of a copolymerizable ethylenically unsaturated acid with (ii) a copolymerizable ethylenically unsaturated monomer other than said copolymerizable ethylenically unsaturated acid.
Claim 2
Dependent Claim
121 words
An analytical element comprising a support layer having an upper side and a lower side, a reagent layer which is positioned on one of said sides of said support and contains a reagent reactive with a component in a fluid sample, and a porous spreading layer which is positioned on the reagent layer on the opposite side to said support for permitting the component in said fluid sample to permeate into said reagent layer; wherein at least one of said layers contains at least 5% by weight of a copolymer formed by the polymerization of (i) at least 45% by weight of a copolymerizable ethylenically unsaturated acid with (ii) a copolymerizable ethylenically unsaturated monomer other than said copolymerizable ethylenically unsaturated acid.
Claim 3
Dependent Claim
127 words
An analytical element according to claim 1, wherein said copolymerizable ethylenically unsaturated acid is selected from the group consisting of the following formulas [I] and [II]: ##STR8## wherein R 1 represents a carboxyl group, a sulfo group or a group having a carboxyl group or a sulfo group, R 2 represents a hydrogen atom or an alkyl group and R 3 represents a hydrogen atom or an alkoxycarbonyl group, and ##STR9## wherein R 4 represents a hydrogen atom or a methyl group, R 5 represents an aliphatic hydrocarbon group having 2 to 10 carbon atoms or ##STR10## where R 7 is an aliphatic hydrocarbon group having 2 to 6 carbon atoms and m is an integer of 1 to 5 and R 6 represents a hydrogen atom.
Claim 4
Dependent Claim
16 words
An analytical element according to claim 1, wherein said copolymer is present in said reagent layer.
Claim 5
Dependent Claim
51 words
An analytical element according to claim 1, wherein said copolymerizable ethylenically unsaturated monomer (ii) is selected from the group consisting of an ethylenically unsaturated nitrile, a styrene, an ethylenically unsaturated acid ester, an ethylenically unsaturated acid amide, a conjugated diene, a vinyl heterocyclic compound, a halo-substituted ethylene and a cross-linkable monomer.
Claim 6
Dependent Claim
65 words
An analytical element according to claim 4, wherein said ethylenically unsaturated monomer (ii) is an ethylenically unsaturated nitrile represented by the following formula [III]: ##STR11## wherein R 8 and R 9 each represent a hydrogen atom or a halogen atom, R 10 represents a halogen atom, an alkyl group, an alkoxy group, an acyloxy group, an aryl group, a cyano group or a carbamoyl group.
Claim 7
Dependent Claim
71 words
An analytical element according to claim 4, wherein said ethylenically unsaturated monomer (ii) is a styrene represented by the following formula [IV]: ##STR12## wherein R 11 represents a hydrogen atom, a halogen atom or an alkyl group, R 12 represents a hydrogen atom, a halogen atom, an allkyl group, an alkoxy group, a cycloalkyl group, an alkoxycarbonyl group or an acryloxyalkyl group, and n is an integer of 1 to 5.
Claim 8
Dependent Claim
48 words
An analytical element according to claim 4, wherein said ethylenically unsaturated monomer (ii) is an ethylenically unsaturated acid ester represented by the following formula [V]: ##STR13## wherein R 13 represents a hydrogen atom or a methyl group, and R 14 represents an alkyl group or a phenyl group.
Claim 9
Dependent Claim
58 words
An analytical element according to claim 4, wherein said ethylenically unsaturated monomer (ii) is a conjugated diene represented by the following formula [VI]: ##STR14## wherein R 15 through R 20 individually represent a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cyano group or a group --COOR.sub.21 where R 21 represents an alkyl group.
Claim 10
Dependent Claim
15 words
An analytical element according to claim 1, wherein said copolymer is copoly(2-acrylamide-2-methylethane sulfonic acid--n-butyl acrylate.
Claim 11
Dependent Claim
22 words
An analytical element according to claim 9, wherein the weight ratio of sulfonic acid to n-butyl acrylate in said copolymer is 4:1.
Claim 12
Dependent Claim
16 words
An analytical element according to claim 10, wherein said copolymer is present in said reagent layer.
Claim 13
Dependent Claim
15 words
An analytical element according to claim 1, wherein said copolymer is copoly(2-acrylamide-2-methylpropane sulfonic acid--butyl acrylate.
Claim 14
Dependent Claim
22 words
An analytical element according to claim 12, wherein the weight ratio of sulfonic acid to butyl acrylate in said copolymer is 1:1.
Claim 15
Dependent Claim
16 words
An analytical element according to claim 13, wherein said copolymer is present in said reagent layer.
Claim 16
Dependent Claim
14 words
An analytical element according to claim 1, wherein said copolymer is copoly(2-acrylamide-2-methylpropane sulfonic acid--acrylamide.
Claim 17
Dependent Claim
21 words
An analytical element according to claim 15, wherein the weight ratio of sulfonic acid to acrylamide is said copolymer is 1:1.
Claim 18
Dependent Claim
16 words
An analytical element according to claim 16, wherein said copolymer is present in said reagent layer.
References Cited (Backward Citations)
US4258001A
Cited
DE3133538A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-03-17 | 1989-09-16 | 1990-03-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-17 | 1993-09-16 | 1994-03-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-17 | 1997-09-16 | 1998-03-18 | $7700.00 | Window Closed / Lapsed |