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US4575548A Expired / Lapsed US ⏱️ 0.0 years remaining

Occlusion compound of 2-nitroxymethyl-6-chloropyridine with β-cyclodextrin and process for preparation thereof

Assignee: Astellas Pharma Inc
•
Filing: 1984-09-26
•
Granted: 1986-03-11
•
Expires: 2004-09-26
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Abstract

Abstract An occlusion compound of 2-nitroxymethyl-6-chloropyridine with beta -cyclodextrin is disclosed herein as well as a process for preparing the occlusion compound thereof. The occlusion compound of the present invention has a molar ratio of 2-nitroxymethyl-6-chloropyridine to beta -cyclodextrin of between about 1:1 and about 3:1. The present occlusion compound is nonvolatile, thereby overcoming the problems associated with the volatility of the 2-nitroxymethyl-6-chloropyridine for pharmacuetical preparations. The process of the present invention is carried out by reacting 2-nitroxymethyl-6-chloropyridine with beta -cyclodextrin either by kneading both compounds together with a small amount of a solvent or by mixing both compounds in an appropriate solvent, such as water. The occlusion compound is then precipitated, separated and further purified by conventional methods.

Inventors

  • 👤 Yoshio Ueda
  • 👤 Fumio Shimojo
  • 👤 Kiyoshige Yoshida

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-27 12:29
CPC Classifications
C; C12; C12N; C12N15/00; B; B82; B82Y; B82Y5/00; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K47/00; A61K47/50; A61K47/69; A61K47/6949; A61K47/6951; A61P; A61P9/00; C07; C07D; C07D211/00; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0012; C08B37/0015

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 7 words
An occlusion compound of 2-nitroxymethyl-6-chloropyridine with β-cyclodextrin.
Claim 2
Dependent Claim 7 words
An occlusion compound of 2-nitroxymethyl-6-chloropyridine with β-cyclodextrin.
Claim 3
Dependent Claim 70 words
The occlusion compound of claim 1 which has the following physical properties: (i) its X ray powder diffraction pattern is characterized by peaks at about 11.5°, 17.2° and 18.4°; (ii) its infrared absorption spectrum (Nujol), is characterized by absorption peaks at about 3300, 1645, 1586, 1568, 1459, 1376, 1330, 1281, 1158, 1080, 1022, 1000, 940 and 842 cm -1 ; (iii) the occlusion compound is sparingly soluble in water water.
Claim 4
Dependent Claim 20 words
The occlusion compound of claim 1 wherein the molar ratio of 2-nitroxymethyl-6-chloropyridine to β-cyclodextrin is between about 1:1 and 3:1.
Claim 5
Dependent Claim 40 words
A process for preparing an occlusion compound of 2-nitroxymethyl-6-chloropyridine with β-cyclodextrin comprising (a) admixing 2-nitroxymethyl-6-chloropyridine with an aqueous solution of β-cyclodextrin; (b) allowing for the occlusion compound to precipitate; and (c) separating the precipitated occlusion compound from the aqueous solution.
Claim 6
Dependent Claim 40 words
A process for preparing an occlusion compound of 2-nitroxymethyl-6-chloropyridine with β-cyclodextrin comprising (a) admixing 2-nitroxymethyl-6-chloropyridine with an aqueous solution of β-cyclodextrin; (b) allowing for the occlusion compound to precipitate; and (c) separating the precipitated occlusion compound from the aqueous solution.
Claim 7
Dependent Claim 13 words
The process of claim 4, wherein step (c) is carried out by centrifugation.
Claim 8
Dependent Claim 20 words
The process of claim 4 further comprising: (d) washing the separated occlusion compound with water in order to remove impurities.

References Cited (Backward Citations)

US2959580A Cited
US3420788A Cited
US4365061A Cited
US4482709A Cited
JPS5867670A Cited
US4425336A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1989-03-10 1989-09-09 1990-03-11 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1993-03-10 1993-09-09 1994-03-11 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1997-03-10 1997-09-09 1998-03-11 $7700.00 Window Closed / Lapsed

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