US4575507A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
Assignee: Pfizer Inc
•
Filing: 1985-05-29
•
Granted: 1986-03-11
•
Expires: 2005-05-29
Abstract
Abstract Compounds related to 3',4'-dihydrospiro[imidazolidine-4,1'(2'H)-naphthalene]2,3',5-trione, spiro[chroman-4,4'-imidazolidine]2,2',5'-trione and 1',2'-dihydrospiro[imidazolidine-4,4'-(3'H)-quinoline 2,2'5-trione and reduced products thereof as aldose reductase inhibitors.
Inventors
- 👤 Christopher A. Lipinski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 13:04
CPC Classifications
C; C07; C07D; C07D235/00; C07D235/02; A; A61; A61P; A61P27/00; A61P27/02; A61P27/12; A61P3/00; A61P3/08; A61P3/10; C07D471/00; C07D471/02; C07D471/10; C07D491/00; C07D491/02; C07D491/10
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
42 words
A spiro-imidazolone of the formula ##STR9## and a pharmaceutically acceptable base salt thereof, wherein R is selected from the group consisting of fluoro, chloro, hydrogen, methyl and methoxy; and X is selected from the group consisting of --O--, CH 2 and NH.
Claim 2
Dependent Claim
42 words
A spiro-imidazolone of the formula ##STR9## and a pharmaceutically acceptable base salt thereof, wherein R is selected from the group consisting of fluoro, chloro, hydrogen, methyl and methoxy; and X is selected from the group consisting of --O--, CH 2 and NH.
Claim 3
Dependent Claim
11 words
A compound of claim 1, wherein X is CH 2 .
Claim 4
Dependent Claim
9 words
The compound of claim 2, wherein R is fluoro.
Claim 5
Dependent Claim
9 words
The compound of claim 2, wherein R is hydrogen.
Claim 6
Dependent Claim
9 words
A compound of claim 1, wherein X is NH.
Claim 7
Dependent Claim
9 words
The compound of claim 5, wherein R is chloro.
Claim 8
Dependent Claim
42 words
A spiro-imidazolone of the formula ##STR10## and a pharmaceutically acceptable base salt thereof wherein R is selected from the group consisting of fluoro, chloro, hydrogen, methyl and methoxy; and Y is selected from the group consisting of O and CH 2 .
Claim 9
Dependent Claim
42 words
A spiro-imidazolone of the formula ##STR10## and a pharmaceutically acceptable base salt thereof wherein R is selected from the group consisting of fluoro, chloro, hydrogen, methyl and methoxy; and Y is selected from the group consisting of O and CH 2 .
Claim 10
Dependent Claim
9 words
A compound of claim 7, wherein Y is O.
Claim 11
Dependent Claim
9 words
The compound of claim 8, wherein R is fluoro.
Claim 12
Dependent Claim
37 words
A pharmaceutical composition which comprises a pharmaceutically-acceptable carrier and a compound selected from claim 1 or claim 7, and wherein the weight-ratio of the pharmaceutically-acceptable carrier to said compound is in the range of 1:4 to 20:1.
Claim 13
Dependent Claim
40 words
A method of treating a diabetic host to prevent or alleviate ocular or neuritic diabetes-associated chronic complications, which comprises administering to said diabetic host an alleviating or prophylactically effective amount of a compound selected from claim 1 or claim 7.
References Cited (Backward Citations)
US4235911A
Cited
US4540704A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-03-10 | 1989-09-09 | 1990-03-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-10 | 1993-09-09 | 1994-03-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-10 | 1997-09-09 | 1998-03-11 | $7700.00 | Window Closed / Lapsed |