US4575500A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antifungal substances and process for their production
Assignee: Merck and Co Inc
•
Filing: 1984-03-26
•
Granted: 1986-03-11
•
Expires: 2004-03-26
Abstract
Abstract There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compound's structure is presented based upon analytical studies. The compound has antifungal activity.
Inventors
- 👤 Richard W. Burg
- 👤 Lucille J. Cole
- 👤 Sebastian Hernandez
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 20:36
CPC Classifications
A; A01; A01N; A01N57/00; A01N57/10; A01N57/12; C; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/117; C12P; C12P13/00; C12R; C12R2001/00; C12R2001/01; C12R2001/465; C12R2001/55; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886; Y10S435/898
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
48 words
A compound having the formula: ##STR5## wherein the compounds have the following values for R 1 , R 2 and R 3 : ______________________________________
R.sub.1 R.sub.2 R.sub.3
______________________________________
##STR6## NH.sub.3.sup.⊕
OPO.sub.3 H.sup.⊖
II H NH.sub.3.sup.⊕
OPO.sub.3 H.sup.⊖
III
##STR7## NH.sub.3.sup.⊕
OPO.sub.3 H.sup.⊖
IV
##STR8## OH OPO.sub.3 H.sub.2
______________________________________
Claim 2
Dependent Claim
48 words
A compound having the formula: ##STR5## wherein the compounds have the following values for R 1 , R 2 and R 3 : ______________________________________
R.sub.1 R.sub.2 R.sub.3
______________________________________
##STR6## NH.sub.3.sup.⊕
OPO.sub.3 H.sup.⊖
II H NH.sub.3.sup.⊕
OPO.sub.3 H.sup.⊖
III
##STR7## NH.sub.3.sup.⊕
OPO.sub.3 H.sup.⊖
IV
##STR8## OH OPO.sub.3 H.sub.2
______________________________________
Claim 3
Dependent Claim
23 words
The compound of claim 1 wherein R 1 is ##STR9## R 2 is --NH 3 .sup.⊕ and R 3 is --O--PO 3 H.sup.⊖.
Claim 4
Dependent Claim
23 words
The compound of claim 1 wherein R 1 is H, R 2 is --NH 3 .sup.⊕ and R 3 is --O--PO 3 H⊖.
Claim 5
Dependent Claim
23 words
The compound of claim 1 wherein R 1 is ##STR10## R 2 is --NH 3 .sup.⊕ and R 3 is --O--PO 3 H.sup.⊖.
Claim 6
Dependent Claim
23 words
The compound of claim 1 wherein R 1 is ##STR11## R 2 is --OH and R 3 is --O--PO 3 H 2 .
Claim 7
Dependent Claim
17 words
An antifungal composition which comprises one or more compounds of claim 1 and a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
24 words
A method for the treatment of fungus infections which comprises treating an area infected with fungi with one or more compounds of claim 1.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-03-10 | 1989-09-09 | 1990-03-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-10 | 1993-09-09 | 1994-03-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-10 | 1997-09-09 | 1998-03-11 | $7700.00 | Window Closed / Lapsed |