US4572899A
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US
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Aqueous solution for suspending and storing cells, especially erthrocytes
Assignee: NPBI NEDERLANDS PRODUKTIELABORATORIUM VOOR BLOEDTRANSFUSIEAPPARATUUR EN INFUSIEVLOEISTOFFEN BV A DUTCH Corp
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Filing: 1983-07-06
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Granted: 1986-02-25
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Expires: 2003-07-06
Abstract
Abstract An aqueous solution for suspending and storing cells, especially erythrocytes, and containing sodium chloride, glucose or fructose, adenine, and a sugar alcohol, the sugar alcohol being sorbitol or xylitol is employed to further improve the storage time and hence the survival rate of the cells and even reduce the hemolysis rate of erythrocytes in packed red blood cells.
Inventors
- 👤 Wolfram H. Walker
- 👤 Karlheinz Ganshirt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 23:22
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/18; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/106664; Y10T436/107497; Y10T436/108331
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
48 words
Aqueous solution for suspending and storing cells, especially erythrocytes, and containing per liter 0.5-20 g of sodium chloride, 0.5-20 g of glucose or fructose, 0.05-1 g of adenine, guanosine in up to 1.5 g, 0-5 g of at least one phosphate and 1-20 g of sorbitol or xylitol.
Claim 2
Dependent Claim
48 words
Aqueous solution for suspending and storing cells, especially erythrocytes, and containing per liter 0.5-20 g of sodium chloride, 0.5-20 g of glucose or fructose, 0.05-1 g of adenine, guanosine in up to 1.5 g, 0-5 g of at least one phosphate and 1-20 g of sorbitol or xylitol.
Claim 3
Dependent Claim
8 words
A solution according to claim 1 containing sorbitol.
Claim 4
Dependent Claim
18 words
A solution according to claim 1 wherein at least one of said phosphates is hydrogenorthophosphate or a dihydrogenorthophosphate.
Claim 5
Dependent Claim
53 words
A solution according to claim 2 comprising 4.2 g of sodium chloride, 1.14 g of dibasic sodium phosphate×2H 2 O, 1.11 g of monobasic sodium phosphate×H 2 O, 9.4 g of glucose monohydrate, 10.0 g of sorbitol, 0.25 g of adenine hydrochloride, and 0.4 g of guanosine per liter of water for injections.
Claim 6
Dependent Claim
10 words
A solution according to claim 1 additionally containing a colloid.
Claim 7
Dependent Claim
11 words
A composition comprising erythrocytes and the aqueous solution of claim 1.
Claim 8
Dependent Claim
12 words
A composition according to claim 6 wherein said aqueous solution contains sorbitol.
Claim 9
Dependent Claim
29 words
A process for washing erythrocytes which comprises mixing said erythrocytes with the solution of claim 1, thereafter removing at least a portion of said solution, and recovering the erythrocytes.
Claim 10
Dependent Claim
21 words
A solution according to claim 1, wherein at least one of said phosphates is dibasic sodium phosphate or monobasic sodium phosphate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-02-24 | 1989-08-26 | 1990-02-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-02-24 | 1993-08-26 | 1994-02-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-02-24 | 1997-08-26 | 1998-02-25 | $7700.00 | Window Closed / Lapsed |