US4570068A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Interface for liquid chromatograph and mass spectrometer
Assignee: Hitachi Ltd
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Filing: 1983-11-14
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Granted: 1986-02-11
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Expires: 2003-11-14
Abstract
Abstract An interface for liquid chromatograph/mass spectrometer (LC/MS) comprises a liquid chromatograph, an atomizing means for successively atomizing an effluent from the liquid chromatograph, and a mass spectrometer for mass-analyzing samples from the atomizing means, where the atomizing means comprises a conical horn and an ultrasonic vibrator. The conical horn has, along its center line, a perforation for passing the effluent. The ultrasonic vibrator is of a doughnut type and is provided around the conical horn and partly in close contact with the conical horn. Mists generated at the end of the conical horn are carried into the ion source of the mass spectrometer together with a carrier gas.
Inventors
- 👤 Minoru Sakairi
- 👤 Hideki Kambara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 21:14
CPC Classifications
H; H01; H01J; H01J49/00; H01J49/02; H01J49/04; H01J49/0431; H01J49/0454; G; G01; G01N; G01N30/00; G01N30/02; G01N30/62; G01N30/72; G01N30/7233; G01N30/724; G01N30/7246
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
140 words
An interface for liquid chromatograph and mass spectrometer, which comprises a liquid chromatograph, an ultrasonic atomizing means for successively atomizing an effluent from the liquid chromatograph, a mass spectrometer for mass-analyzing samples from the ultrasonic atomizing means, the ultrasonic atomizing means including a conical horn having a perforation for guiding the effluent from the liquid chromatograph and an ultrasonic vibrator provided in close contact with the conical horn, the ultrasonic atomizing means providing atomized mists of different particle size of the effluent in a vertically downward direction, and a carrier gas inlet means disposed adjacent to an outlet of the ultrasonic atomizing means for supplying a carrier gas in a predetermined direction transverse to the vertically downward direction of the atomized mists for carrying only atomized mists having a particle size less than a predetermined value to the mass spectrometer.
Claim 2
Dependent Claim
140 words
An interface for liquid chromatograph and mass spectrometer, which comprises a liquid chromatograph, an ultrasonic atomizing means for successively atomizing an effluent from the liquid chromatograph, a mass spectrometer for mass-analyzing samples from the ultrasonic atomizing means, the ultrasonic atomizing means including a conical horn having a perforation for guiding the effluent from the liquid chromatograph and an ultrasonic vibrator provided in close contact with the conical horn, the ultrasonic atomizing means providing atomized mists of different particle size of the effluent in a vertically downward direction, and a carrier gas inlet means disposed adjacent to an outlet of the ultrasonic atomizing means for supplying a carrier gas in a predetermined direction transverse to the vertically downward direction of the atomized mists for carrying only atomized mists having a particle size less than a predetermined value to the mass spectrometer.
Claim 3
Dependent Claim
43 words
An interface according to claim 1, wherein the mass spectrometer comprises an ion source for ionizing the samples from the ultrasonic atomizing means, as carried by the carrier gas, and an analyzer for mass-analyzing the ions of samples generated in the ion source.
Claim 4
Dependent Claim
15 words
An interface according to claim 2, wherein the ionization is carried out at atmospheric pressure.
Claim 5
Dependent Claim
33 words
An interface according to claim 1 or 2, wherein the ultrasonic vibrator which is in close contact with the conical horn is provided, thereby atomizing the effluent at the end of the horn.
Claim 6
Dependent Claim
23 words
An interface according to claim 1 or 2, wherein the perforation has a smaller inner diameter at the end of the conical horn.
Claim 7
Dependent Claim
33 words
An interface according to claim 1 or 2, wherein the perforation extends through the conical horn in the vertically downward direction so that the conical horn is open at its vertically downward end.
Claim 8
Dependent Claim
39 words
An interface according to claim 1 or 2, wherein a means for eliminating atomized mists of larger particle size than the predetermined value is provided under an open end of the perforation at the end of the conical horn.
Claim 9
Dependent Claim
32 words
An interface according to claim 1, further comprising means disposed in the vertically downward direction of the atomized mists for eliminating atomized mists having a particle size larger than the predetermined value.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-02-10 | 1989-08-12 | 1990-02-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-02-10 | 1993-08-12 | 1994-02-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-02-10 | 1997-08-12 | 1998-02-11 | $7700.00 | Window Closed / Lapsed |